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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	MK-912
Molecular formula	C20H25N3O2
IUPAC name	1',3'-dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4'-1,3-diazinane]-2'-one
Molecular weight	339.439
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.3
Synonyms	CAS_123679 L-657,743-002W NCGC00015699-03 1',3'-Dimethylspiro(1,3,4,5',6,6',7,12b-octahydro-2H-benzo(b)furo(2,3-a)quinolizine)-2,4'-pyrimidin-2'-one CHEMBL1256985 LS-186865 PDSP1_001652 AC1L3X3J L 657743 CCG-204845 L023963 NCGC00162243-01 1',3'-dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4'-1,3-diazinane]-2'-one D0Y4LU LS-187521 PDSP2_001636 BDBM81811 L-657,743 NCGC00015699-02 Lopac0_000760 NSC_123679 L 657,743 MK 912 Spiro(2H-benzofuro(2,3-a)quinolizine-2,4'(1'H)-pyrimidin)-2'(3'H)-one, 1,3,4,5',6,6',7,12b-octahydro-1',3'-dimethyl-, (2S-trans)- [ Show all ]
Inchi Key	JRDUBBHIPPPSLP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25N3O2/c1-21-11-8-20(22(2)19(21)24)9-12-23-10-7-15-14-5-3-4-6-17(14)25-18(15)16(23)13-20/h3-6,16H,7-13H2,1-2H3
PubChem CID	123679
ChEMBL	CHEMBL1256985
IUPHAR	N/A
BindingDB	81811
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
157921	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
157919	Alpha-2B adrenergic receptor	P19328	Adra2b	Rattus norvegicus (Rat)	453
460645	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
157922	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
157920	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446

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