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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	Spiroxatrine
Molecular formula	C22H25N3O3
IUPAC name	8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight	379.46
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	S-103 SR-01000075579 ( inverted exclamation markA)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one 8-(1,4-Benzodioxan-2-ylmethyl)-1-phenyl-1,3,8-trianaspiro(4,5)decane-4-one BDBM50020192 CHEBI:91845 DTXSID3045198 J-001433 NCGC00015908-05 NCGC00024696-05 Tox21_110260 1,3,8-Trianaspiro(4.5)decane-4-one,8-(1,4-benzodioxan-2-ylmethyl)-1-phenyl- 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one BPBio1_001395 CTK8G3191 EU-0101142 LP01142 NCGC00015908-08 NSC 665322 R 5188 Spiroxatrinum AC1L1JZ3 CAS-1054-88-2 DSSTox_GSID_45198 HMS3263F05 NCGC00015908-03 NCGC00024696-03 SCHEMBL1255303 SR-01000075579-1 (+/-)-8-[(2,3-Dihydro-1,4-Benzodioxin-2-yl)Methyl]-1-Phenyl-1,3,8-Triazaspiro [4,5]Decan-4-one 8-(1,4-benzodioxan-2-ylmethyl)-1-phenyl-1,3,8-triazaspiro(4,5)-decan-4-one Biomol-NT_000104 Espiroxatrina L001271 NCGC00015908-06 NCGC00261827-01 Spiroxatrine (R 5188) Tox21_110260_1 1054-88-2 8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one BRD-A72483914-001-01-1 D0MU4A GTPL53 LS-171963 NCGC00015908-09 NSC-665322 R-5188 Spiroxatrinum [INN-Latin] 8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one AKOS024458589 CCG-205216 DSSTox_RID_80744 HMS3266D15 NCGC00015908-04 NCGC00024696-04 SPIROXAMIDE SR-01000075579-3 8-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one BN0501 CHEMBL300555 Espiroxatrina [INN-Spanish] Lopac0_001142 NCGC00015908-07 NCI60_022532 Spiroxatrine [INN] Tox21_501142 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one BRD-A72483914-001-02-9 DSSTox_CID_25198 HMS2089G17 MolPort-003-983-690 NCGC00024696-02 NSC665322 [ Show all ]
Inchi Key	JVGBTTIJPBFLTE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)
PubChem CID	5268
ChEMBL	CHEMBL300555
IUPHAR	53
BindingDB	50020192
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
160835	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
160845	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
160843	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
160849	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
160854	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
160840	5-hydroxytryptamine receptor 2B	P30994	Htr2b	Rattus norvegicus (Rat)	479
160841	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
554088	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
554089	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
554090	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
160832	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
160842	Alpha-2A adrenergic receptor	P18871	ADRA2A	Sus scrofa (Pig)	450
160844	Alpha-2A adrenergic receptor	P22909	Adra2a	Rattus norvegicus (Rat)	450
160851	Alpha-2A adrenergic receptor	Q28838	ADRA2A	Bos taurus (Bovine)	452
160834	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
160838	Alpha-2B adrenergic receptor	O77715	ADRA2B	Didelphis virginiana (North American opossum)	382
160839	Alpha-2B adrenergic receptor	P19328	Adra2b	Rattus norvegicus (Rat)	453
160853	Alpha-2B adrenergic receptor	O77830	ADRA2B	Oryctolagus cuniculus (Rabbit)	394
160833	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
160837	Alpha-2C adrenergic receptor	P22086	Adra2c	Rattus norvegicus (Rat)	458