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Ligand

NameZiprasidone
Molecular formulaC21H21ClN4OS
IUPAC name5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
Molecular weight412.936
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.0
Synonyms2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-
GTPL59
4770-EP2298776A1
MVWVFYHBGMAFLY-UHFFFAOYSA-N
5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one
[ Show all ]
Inchi KeyMVWVFYHBGMAFLY-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
PubChem CID60854
ChEMBLCHEMBL708
IUPHAR59
BindingDB50048803
DrugBankDB00246

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 52
Page:  / 3 

GLASS IDNameUniProtGeneSpeciesLength
2155115-hydroxytryptamine receptor 1AP08908HTR1AHomo sapiens (Human)422
2155455-hydroxytryptamine receptor 1AP19327Htr1aRattus norvegicus (Rat)422
2155085-hydroxytryptamine receptor 1BP28222HTR1BHomo sapiens (Human)390
2155365-hydroxytryptamine receptor 1BP28564Htr1bRattus norvegicus (Rat)386
2155355-hydroxytryptamine receptor 1DP28221HTR1DHomo sapiens (Human)377
2154995-hydroxytryptamine receptor 1EP28566HTR1EHomo sapiens (Human)365
2154965-hydroxytryptamine receptor 2AP14842Htr2aRattus norvegicus (Rat)471
2155225-hydroxytryptamine receptor 2AP28223HTR2AHomo sapiens (Human)471
2155285-hydroxytryptamine receptor 2BP41595HTR2BHomo sapiens (Human)481
2154985-hydroxytryptamine receptor 2CP28335HTR2CHomo sapiens (Human)458
2155135-hydroxytryptamine receptor 2CP08909Htr2cRattus norvegicus (Rat)460
2155145-hydroxytryptamine receptor 5AP47898HTR5AHomo sapiens (Human)357
2155005-hydroxytryptamine receptor 6P50406HTR6Homo sapiens (Human)440
2155045-hydroxytryptamine receptor 7P34969HTR7Homo sapiens (Human)479
2155375-hydroxytryptamine receptor 7P32304Htr7Mus musculus (Mouse)448
215510Alpha-1A adrenergic receptorP35348ADRA1AHomo sapiens (Human)466
215532Alpha-1A adrenergic receptorP43140Adra1aRattus norvegicus (Rat)466
215526Alpha-1B adrenergic receptorP35368ADRA1BHomo sapiens (Human)520
215505Alpha-2A adrenergic receptorP08913ADRA2AHomo sapiens (Human)450
215542Alpha-2B adrenergic receptorP18089ADRA2BHomo sapiens (Human)450

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