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Ligand

NameAF-DX 384
Molecular formulaC27H38N6O2
IUPAC nameN-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Molecular weight478.641
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.8
SynonymsL003043
PDSP1_000962
[3H]AF-DX 384
AFDX-384
MZDYABXXPZNUCT-UHFFFAOYSA-N
[ Show all ]
Inchi KeyMZDYABXXPZNUCT-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)
PubChem CID119357
ChEMBLCHEMBL279453
IUPHAR3264, 368
BindingDB81901
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 6
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
217762Muscarinic acetylcholine receptor DM1P16395mAChR-ADrosophila melanogaster (Fruit fly)805
217763Muscarinic acetylcholine receptor M1P11229CHRM1Homo sapiens (Human)460
217761Muscarinic acetylcholine receptor M2P08172CHRM2Homo sapiens (Human)466
217759Muscarinic acetylcholine receptor M3P20309CHRM3Homo sapiens (Human)590
217760Muscarinic acetylcholine receptor M4P08173CHRM4Homo sapiens (Human)479
217764Muscarinic acetylcholine receptor M5P08912CHRM5Homo sapiens (Human)532

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