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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL274599
Molecular formula	C28H34N4O2
IUPAC name	2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]-2-methylpropanamide
Molecular weight	458.606
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	3.7
Synonyms	1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1H-indene-1,4''-(hexahydropyridine)]-1-ylethyl]-2-amino-2-methylpropanamide L-162752 BDBM50069108 1-{[(2R)-1-{2,3-dihydrospiro[indene-1,4''-piperidine]-1''-yl}-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium SCHEMBL2578898 BDBM50403630 1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1H-indene-1,4''-(hexahydropyridine)]-1-yl-(1R)-ethyl]-2-amino-2-methylpropanamide CHEMBL558802 [ Show all ]
Inchi Key	NQEGSKXLUMFKJZ-XMMPIXPASA-N
Inchi ID	InChI=1S/C28H34N4O2/c1-27(2,29)26(34)31-24(17-20-18-30-23-10-6-4-8-21(20)23)25(33)32-15-13-28(14-16-32)12-11-19-7-3-5-9-22(19)28/h3-10,18,24,30H,11-17,29H2,1-2H3,(H,31,34)/t24-/m1/s1
PubChem CID	9890375
ChEMBL	CHEMBL274599
IUPHAR	N/A
BindingDB	50069108, 50403630
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
229460	Growth hormone secretagogue receptor type 1	Q92847	GHSR	Homo sapiens (Human)	366
229461	Growth hormone secretagogue receptor type 1	O08725	Ghsr	Rattus norvegicus (Rat)	364
229459	Growth hormone-releasing hormone receptor	Q02644	Ghrhr	Rattus norvegicus (Rat)	464

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