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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	AZD-6538
Molecular formula	C15H6FN5O
IUPAC name	6-[5-(3-cyano-5-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyridine-3-carbonitrile
Molecular weight	291.245
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	2.0
Synonyms	GTPL6440 AZD6538 6-(5-(3-cyano-5-fluorophenyl)-1,2,4-oxadiazol-3-yl)nicotinonitrile CHEMBL2164552 AZD 6538 SCHEMBL4186520 453566-30-8 BDBM50395922 6-[5-(3-cyano-5-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyridine-3-carbonitrile D09XHI [ Show all ]
Inchi Key	PBVKGEMPZBKZOA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H6FN5O/c16-12-4-10(7-18)3-11(5-12)15-20-14(21-22-15)13-2-1-9(6-17)8-19-13/h1-5,8H
PubChem CID	9879103
ChEMBL	CHEMBL2164552
IUPHAR	6440
BindingDB	50395922
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
255965	Metabotropic glutamate receptor 1	Q13255	GRM1	Homo sapiens (Human)	1194
255971	Metabotropic glutamate receptor 2	Q14416	GRM2	Homo sapiens (Human)	872
255970	Metabotropic glutamate receptor 3	Q14832	GRM3	Homo sapiens (Human)	879
255967	Metabotropic glutamate receptor 4	Q14833	GRM4	Homo sapiens (Human)	912
255966	Metabotropic glutamate receptor 5	P41594	GRM5	Homo sapiens (Human)	1212
255969	Metabotropic glutamate receptor 5	P31424	Grm5	Rattus norvegicus (Rat)	1203
255964	Metabotropic glutamate receptor 6	O15303	GRM6	Homo sapiens (Human)	877
255968	Metabotropic glutamate receptor 7	Q14831	GRM7	Homo sapiens (Human)	915
255963	Metabotropic glutamate receptor 8	O00222	GRM8	Homo sapiens (Human)	908

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