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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
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Ligand

Name	methiothepin
Molecular formula	C20H24N2S2
IUPAC name	1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine
Molecular weight	356.546
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.2
Synonyms	NINDS_000913 RLJFTICUTYVZDG-UHFFFAOYSA-N Spectrum3_001602 AKOS005065442 BRD-A07932845-066-08-9 CHEBI:64203 DSSTox_GSID_44000 KBioGR_001504 Methiothepine NCGC00024665-02 NCGC00024665-05 Piperazine, 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-, (2Z)-2-butenedioate (1:1) 1-methyl-4-(8-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)piperazine SCHEMBL113526 96654-EP2298738A1 Tox21 110916 Biomol-NT_000094 BSPBio_000529 cid_3039995 GTPL89 LS-111708 Metitepine NCGC00024665-10 (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin Prestwick2_000375 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine SPBio_002450 AB00053700_19 VUFB-6276 BRD-A07932845-001-01-1 CAS-20229-30-5 DivK1c_000913 KBio1_000913 methanesulfonic acid;1-methyl-4-[3-(methylthio)-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine Metitepinum [INN-Latin] Piperazine, 1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methyl- 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine Ro-8-6837 Spectrum4_001092 API0015806 BRD-A07932845-103-01-5 DSSTox_RID_80096 L000397 Metitepina NCGC00024665-03 NCGC00024665-06 Prestwick0_000375 1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine SMR000326779 96654-EP2305678A1 Tox21_110916 BPBio1_000583 BSPBio_003203 D0X6MT HMS2089P11 mesylic acid;1-methyl-4-[3-(methylthio)-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine Metitepine [INN] NCI60_002300 (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin Prestwick3_000375 20229-30-5 Spectrum2_001967 AC1L1HFA BRD-A07932845-050-05-9 CCG-204888 DSSTox_CID_24000 KBio3_002423 MLS000859918 NCGC00024665-04 Piperazine, 1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methyl-, (+-)- 1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine SBI-0050781.P003 96654-EP2287163A1 Spectrum5_001832 BDBM78940 BRN 0626221 CHEMBL93240 DTXSID2044000 Lopac0_000804 Metitepina [INN-Spanish] NCGC00024665-07 (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine Prestwick1_000375 1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine SPBio_002093 AB00053700 Tox21_110916_1 BPBio1_001352 C20H24N2S2 Dibenzo(b,f)thiepin, 10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)- (+-) IDI1_000913 methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine Metitepinum [ Show all ]
Inchi Key	RLJFTICUTYVZDG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
PubChem CID	4106
ChEMBL	CHEMBL93240
IUPHAR	89
BindingDB	78940
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
299024	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
299030	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
299020	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
299023	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
299046	5-hydroxytryptamine receptor 1B	O08892	HTR1B	Cavia porcellus (Guinea pig)	389
299015	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
299044	5-hydroxytryptamine receptor 1D	P79400	HTR1D	Sus scrofa (Pig)	291
299047	5-hydroxytryptamine receptor 1D	P28565	Htr1d	Rattus norvegicus (Rat)	374
299027	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
299034	5-hydroxytryptamine receptor 1F	P30939	HTR1F	Homo sapiens (Human)	366
299045	5-hydroxytryptamine receptor 1F	P30940	Htr1f	Rattus norvegicus (Rat)	366
299022	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
299025	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
299019	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
299035	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
299037	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
299026	5-hydroxytryptamine receptor 5A	P35364	Htr5a	Rattus norvegicus (Rat)	357
299038	5-hydroxytryptamine receptor 5A	P47898	HTR5A	Homo sapiens (Human)	357
299041	5-hydroxytryptamine receptor 5A	P30966	Htr5a	Mus musculus (Mouse)	357
299028	5-hydroxytryptamine receptor 5B	P35365	Htr5b	Rattus norvegicus (Rat)	370