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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Naloxone(-)
Molecular formula	C19H21NO4
IUPAC name	4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular weight	327.38
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.1
Synonyms	4aH-8,9c-Iminoethanophenanthro(4,5-bcd)furan-5(6H)-one, N-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy- L000674 Narcan (Salt/Mix) BDBM86260 Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5.alpha.)- Oprea1_030545 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furan-5-one CHEBI:91663 Nalone (Salt/Mix) MCULE-7816779766 Normorphinone, N-allyl-dihydro-14-hydroxy- BRD-A37541666-003-01-6 Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5.alpha.)- SCHEMBL10031249 17-Allyl-4,5-.alpha.-epoxy-3,14-dihydroxymorphinan-6-one CHEMBL609673 AC1L1I51 Morphinan-6-one, 17-allyl-4,5.alpha.-epoxy-3,14-dihydroxy- NSC_10064 CAS_465-65-6 Morphinan-6-one, 4,5.alpha.-epoxy-3,14-dihydroxy-17-(2-propenyl)- UZHSEJADLWPNLE-UHFFFAOYSA-N [ Show all ]
Inchi Key	UZHSEJADLWPNLE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2
PubChem CID	4425
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86260
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
349342	D(1A) dopamine receptor	Q95136	DRD1	Bos taurus (Bovine)	446
349341	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
349339	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
349344	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
349340	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
349343	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
349345	Mu-type opioid receptor	P79350	OPRM1	Bos taurus (Bovine)	401
556909	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
556908	Nociceptin receptor	P35377	Oprl1	Mus musculus (Mouse)	367

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