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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Clorotepine
Molecular formula	C19H21ClN2S
IUPAC name	1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methylpiperazine
Molecular weight	344.901
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.3
Synonyms	D0D3YN NCGC00162287-01 Piperazine, 1-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methyl- 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine 42505-79-3 (monomethanesulfonate salt) CCG-204967 Clorotepine [INN] L000790 OCTOCLOTHEPIN,(+) XRYLGRGAWQSVQW-UHFFFAOYSA-N 1-(8-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methylpiperazine AC1L1B15 CHEMBL64249 Clorotepinum [INN-Latin] Clothepin NCGC00015759-02 PDSP1_001546 13448-22-1 BDBM22872 DTXSID7048451 Octoclothepin SCHEMBL678917 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine;maleate 4789-68-8 (2-maleate salt) CHEBI:135459 CLOROTEPINE(-) clorothepin Lopac0_000885 OCTOCLOTHEPIN,(-) 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine AC1Q3SXZ Clorotepina clothepine NCGC00015759-03 PDSP2_001530 BRD-A19053834-050-06-1 CLOROTEPINE (+) FT-0746338 Octoclothepin maleate VUFB-6281 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methylpiperazine 8-chloro-10-(4-methyl-1-piperazinyl)-10,11-dihydrodibenzo(b,f)thiepin Clorotepinum Clotepin LS-111082 Octoclothepine 1-{6-chloro-2-thiatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-9-yl}-4-methylpiperazine AKOS005065436 Clorotepina [INN-Spanish] [ Show all ]
Inchi Key	XRYLGRGAWQSVQW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21ClN2S/c1-21-8-10-22(11-9-21)17-12-14-4-2-3-5-18(14)23-19-7-6-15(20)13-16(17)19/h2-7,13,17H,8-12H2,1H3
PubChem CID	1238
ChEMBL	CHEMBL64249
IUPHAR	N/A
BindingDB	22872
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
399438	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
399447	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
399436	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
399444	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436
399437	5-hydroxytryptamine receptor 7	P50407	HTR7	Cavia porcellus (Guinea pig)	446
557148	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448
399448	Alpha-1A adrenergic receptor	P18130	ADRA1A	Bos taurus (Bovine)	466
399449	Alpha-1B adrenergic receptor	P18841	ADRA1B	Mesocricetus auratus (Golden hamster)	515
399445	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561
399441	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
399446	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
399435	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
399440	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
399434	D(3) dopamine receptor	P19020	Drd3	Rattus norvegicus (Rat)	446
399439	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
399443	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
399442	Histamine H1 receptor	P35367	HRH1	Homo sapiens (Human)	487
399450	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390
462634	Trace amine-associated receptor 1	Q96RJ0	TAAR1	Homo sapiens (Human)	339

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