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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	duloxetine
Molecular formula	C18H19NOS
IUPAC name	(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
Molecular weight	297.416
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.3
Synonyms	MLS001423946 (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine PDSP1_000969 (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine SBI-0206832.P001 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (S)- Yentreve (TN) AC-15704 AS-35259 D01AXB duloxetine, (+)-isomer KB-211921 LY-248686 NC00013 (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1 amine PDSP2_001369 (S)-N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine SMR000449282 539D594 AJ-26827 BDBM84745 CPD000449282 DTXSID6048385 HMS2051I05 MFCD06801358 (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamin NCGC00164559-04 (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine SAM001247059 116539-59-4 Xeristar AB00639911_15 ANW-63714 CCG-100763 Cymbalta Duloxetine Boehringer Ingelheim J-003455 MolPort-003-847-038 (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine PDSP1_001385 (S)-Duloxetine SC-19047 ZEUITGRIYCTCEM-KRWDZBQOSA-N AC1L1U0Q AX8017669 CHEMBL1175 D07880 FT-0657836 LS-172322 LY248686 NCGC00164559-01 (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine RL00632 (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine UNII-O5TNM5N07U AKOS015851058 C18H19NOS CS-2885 HSDB 7368 MLS000758267 (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine monohydrochloride O5TNM5N07U (S)-(+)-N-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanamine SB19317 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaS)- Yentreve AB00639911_16 Ariclaim CHEBI:36795 Cymbalta (TN) Duloxetine [INN:BAN] J-523680 N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine (3s)-N-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-2-Yl)propan-1-Amine PDSP2_000953 (S)-Duloxetine;LY248686 SCHEMBL8291 29E ZINC1536779 AC1Q57H7 BC209438 CM14423 DB00476 GTPL202 LY 248686 methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine NCGC00164559-02 (3s)-n-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1amine RTC-064103 (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine VA11973 AB00639911-13 AN-15424 CAS_136434-34-9 CTK8B9954 Duloxetine (INN) HY-B0161 [ Show all ]
Inchi Key	ZEUITGRIYCTCEM-KRWDZBQOSA-N
Inchi ID	InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
PubChem CID	60835
ChEMBL	CHEMBL1175
IUPHAR	202
BindingDB	84745
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
426623	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
426635	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
426630	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
426636	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
426624	5-hydroxytryptamine receptor 1F	P30939	HTR1F	Homo sapiens (Human)	366
426631	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
426619	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
426616	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
557239	5-hydroxytryptamine receptor 4	O70528	HTR4	Cavia porcellus (Guinea pig)	388
426622	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
557237	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
426620	Adenosine receptor A1	P25099	Adora1	Rattus norvegicus (Rat)	326
426610	Adenosine receptor A2b	Q1LZD0	ADORA2B	Bos taurus (Bovine)	332
426612	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
557234	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
426626	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
426615	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
557236	Alpha-2B adrenergic receptor	P30545	Adra2b	Mus musculus (Mouse)	450
426625	Beta-1 adrenergic receptor	P18090	Adrb1	Rattus norvegicus (Rat)	466
462835	Beta-2 adrenergic receptor	P10608	Adrb2	Rattus norvegicus (Rat)	418