Detailed GPCR-I-TASSER Statistics for P25101

Submitted Sequence

>sp|P25101|EDNRA_HUMAN
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN

Predicted Secondary Structure

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
Sequence METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
Prediction CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHSSHHHHHHHHHHHHHHHHHSSSSSSSSCCCCSSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCC
Conf.Score 9405866999998665533699612346887555666677777643354678887747788987666786666640289999999999999998688998779753179899799999999999999999998889999999705765787471222007999999999999999999999849897524322406126758511508999999999999998589996306996379986379428899999999999989799999999999999999971658997642467888861328888899999999998999999999999743378431539999999999999999999999999999819999999999961527988875677788887121247997889888877789999

Predicted Solvent Accessibility

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
Sequence METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
Prediction 6311101000000001002023333222113332132232323322233333323222233233334222342413200100000011200100131120000000003402100000000002001010000000100210043022331100100010000001000000000000001303100000021233213200000000011100000000000010131414443100000001342341021000101133331310000020000000101323345444434533442110000000000021013121000100000023313433230100000011101000020000000000001431140024001012234454444343433324343454444434433444348

Predicted Normalized B-Factor


Read more about predicted normalized B-factor

  Top 10 Templates Used by GPCR-I-TASSER


Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
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Sec.Str
Seq		CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHSSHHHHHHHHHHHHHHHHHSSSSSSSSCCCCSSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCC
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
15glhA 0.66 0.46 0.68 2.88Download ------------------------------------------------------------------PPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYK-----NGPNILIASLALGDLLHIVIAIPINVYKLLAEDWP-----FGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWWTA----------VEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKFMQFYATAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKN---------DHLKQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIALYLVSKRFKNAFKSAL-------------------------------------------
25gliA 0.66 0.49 0.74 3.76Download ----------------------------------------------------------------SPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAEDW-----PFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKFMQFYATAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKRTGTWDAYLNDHLKQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIALYLVSKRFKNAFKSALCC-----------------------------------------
34n6hA 0.25 0.20 0.71 3.23Download -------------------------------------------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWP-----FGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD----GAVVCMLQFPSP-SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------
44djh 0.27 0.22 0.68 1.52Download ---------------------------------------------------------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWP-----FGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVR--EDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNIAYREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSAA------------LSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-----------------------------------------
54djh 0.26 0.22 0.68 1.17Download ---------------------------------------------------------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSW-----PFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVRE--DVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNKTYREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSA------------ALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP-----------------------------------------
64n6hA 0.22 0.23 0.86 3.42Download NAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFEGKVKEAQAAAEQLKTTRNAYIQKYLGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWP-----FGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD----GAVVCMLQFP-SPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG---SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRR------DPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------
74djh 0.27 0.22 0.67 1.71Download ------------------------------------------------------------------------------IPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSW-----PFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVD--VIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNDAYREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSA----A--------LSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCF------------------------------------------
84n6hA 0.26 0.20 0.71 4.21Download --------------------------------------------------------------GS----PGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWP-----FGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD----GAVVCMLQFPSP-SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------
95glhA 0.67 0.46 0.68 3.31Download ------------------------------------------------------------------PPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIY-----KNGPNILIASLALGDLLHIVIAIPINVYKLLAEDWP-----FGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWW----------TAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVTAFMQFYATAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKN---------DHLKQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIALYLVSKRFKNAFKSAL-------------------------------------------
105c1mA 0.26 0.21 0.69 3.25Download ----------------------------------------------------------------GSHSLPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWP-----FGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYR----QGSIDCTLTFSHP-TWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGS---KEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF-----------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: SPARKS-X   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: cdPPAS   

  Top 5 Models Predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=0.01 (Read more about C-score)
  • Estimated TM-score = 0.71±0.11
  • Estimated RMSD = 6.9±4.1Å

  • Download Model 2
  • C-score = -1.70

  • Download Model 3
  • C-score = -3.35

  • Download Model 4
  • C-score = -3.61

  • Download Model 5
  • C-score = -3.82


    • [Click on P25101_results.tar.bz2 to download the tarball file including all modeling results listed on this page]