GPCR-I-TASSER results for Q86SQ3

[Click on Q86SQ3_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q86SQ3
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECET
GLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWV
SGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLV
ALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLF
LTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRF
MYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVL
WILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSF
TIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
PredictionCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSSCCCCCCCCCCHHHHSSSSSHHHHHHHHHSSSSSSSCCCCCCCCSSSCCCCCSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHCHSSSSCCHHHHHHHHHHCCCCCCCC
Conf.Score9856999766899899999999388997433887673777873314999986640342479999999973122477377882687715897555677566654577755443446886433445443333345554433443333222223344432234444334434343355543234466544300000011256888999999999987514311443058999999999888632441124555430137889999999999999999999987310210234444531234167643243332233137999526677754586688746899963389999998999999999998764321123462999999999999999999999986054400377609999999999999999988402244508999999999803787899

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
Prediction7301000000240323312630404110302034103133244313473330300010344363044403031230102020241032332423222213222221212022122220112221022122222232222211220212200120221222222221202212222222202133322220100020001000000000000000100012212110000000000010000000112212000000000000000000000000000001000102222222342100000000000000000000000113233311000124100000000000000000010000000000121333344353242000000000000000231110000000233320100000000000030000000000012540041023103424478
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
Sec.Str
Seq
CCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSSCCCCCCCCCCHHHHSSSSSHHHHHHHHHSSSSSSSCCCCCCCCSSSCCCCCSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHCHSSSSCCHHHHHHHHHHCCCCCCCC
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
14l6rA 0.19 0.20 0.67 2.84Download --------------------------------------------------------------------------------------------------------------------------------------------------NEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLAT-----LPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
24l6rA 0.17 0.20 0.83 1.79Download ------------------------------------------ADLEDNWETLNDNKVIEKADNA--KDALTKMRAAALDAQ------KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKL---------------------ANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLL-----GLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
34k5yA 0.23 0.15 0.53 1.90Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVL-----WDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTS--ETIQARKAVKATLVLLPLLGITYMLAFV-----NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
44l6rA 0.16 0.20 0.82 3.31Download ----------------------------------------------------DNWETLNDNLKVIEKDALTKMRAAALDAQ-------------------------KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG-----LATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRAR--QMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
54k5yA 0.25 0.17 0.54 2.66Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTNIFEDKAYDRLRAWMFICIGWGVPFPIIVAWAIGK--LYYDNECWAGKRPGVYYIYQGPMALVLLINFIFLFNIVRILMTKLRASTT--SETIQARK-AVKATLVLPLLGITYMLAFVN-----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
64l6rA 0.16 0.20 0.80 2.35Download -----------------------------------------------------------------------------------ADLEEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQILKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTLAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATL-----PERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
74k5yA 0.25 0.17 0.54 3.65Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTFEMNADAYDRLRAWMFICIGWGVPFPIIVAWAIGK-LYYDNEKCWAGKRPGVYYIYQGPMALVLLINFIFLFNIVRILMTKLRAST--TSETIQARKAVKATLVLLPLLGITYMLAFVN-----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
84k5yA 0.25 0.17 0.54 4.57Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTNEMNRDAYDRLRAWMFICIGWGVPFPIIVAWAIGK-LYYDNEKCWAGKRPGVYYIYQGPMALVLLINFIFLFNIVRILMTKLRASTT--SETIQARKAVKATLVLLPLLGITYMLAFVN-----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
94l6rA 0.18 0.20 0.81 2.05Download ADNDNLKVIEKADNAAQVKDALDAQKA----------TPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGK-----------------------------------------------------------------------VKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTLAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG-----LATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWEERN
104k5yA 0.24 0.15 0.53 2.30Download -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVL--------TDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYDYIYQGPMALVLLINFIFLFNIVRILMTKLR--ASTTSETIQARKAVKATLVLLPLLGITYMLAFV-----NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: MUSTER   3: SPARKS-X   4: Neff-PPAS   5: HHSEARCH2   6: wdPPAS   7: HHSEARCH I   8: HHSEARCH   9: PROSPECT2   10: pGenTHREADER   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-2.38 (Read more about C-score)
  • Estimated TM-score = 0.44±0.14
  • Estimated RMSD = 12.9±4.2Å

  • Download Model 2
  • C-score = -2.91

  • Download Model 3
  • C-score = -3.02

  • Download Model 4
  • C-score = -3.41

  • Download Model 5
  • C-score = -3.68





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).