GPCR-I-TASSER results for Q9NYW5

[Click on Q9NYW5_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q9NYW5
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLG
LFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLL
LKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVS
LVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYI
PYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
PredictionCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCHCHCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCSCCCCSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
Conf.Score96589999999999999999999799999989999817878777599999999999999999982874211523010789999999999980899999999999987024078968999999987727999999999999999999998721001555021565189853378999999999999999999999999999999999999757599999998199999999999999999999999999999974366699999999999995888689997087099999999874169

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
Prediction63332333223213312331331122002001111044340320110000001110100111333000000022223330100000101221320010000000000000022311000001330432001101312231321111201122333333333333302232333212211333333333332133133102100220233034325334113040022002001102222332331133110123334330111112221020011002013031430130013002337
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
Sec.Str
Seq		CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCHCHCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCSCCCCSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
14bwbA 0.11 0.20 0.92 2.53Download ---YSKVLVTAIYLALFVVGTVGNGVTLFT-----LAQSLQSRVDYYLGSLALSDLLILLFALPVDLYNFIHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPFKA----KTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVM----------VEPGRVQALRRGVLVVIAFVVCWLPYHVRRLMFVYISDEQWTHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTLAC--
24n6hA 0.09 0.15 0.94 2.27Download SSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY--TKMK-TATNIYIFNLALADALATST-LPFQSAKYLMETPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD----GAVVCMLQFYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV-----RLLSGSK-EKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPC
34grvA 0.13 0.18 0.93 1.26Download TDIYSKVLVTAIYLALFVVGTVGNSVTLFTLA----RKSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHFGDAGCRGYYFLRDACTYATALNVASLSVARYLAIC---HPFKAK--LMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMSGSVQALR----HGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQWTHYFYMLTNALAYASSAINPILYNLVSANFRQV---------
43rzeA 0.12 0.24 0.91 2.55Download ------MPLVVVLSTICLVTVGLNLLVLYAVRS---ERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQ---QPLRYLKYRT-KTRASATILGAWFLSF-LWVIPILG-WNH-------RREDK-CETDFYDVTWFMTAIINFYLPTLLMLWFYAKIYKAVRQHCNIFEMLRGEATYLHMNRERKAAKQLAAFILCWIPYFIFFMVIAFCKNC-CNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHI--
52z73A 0.12 0.17 0.97 1.86Download VPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTK---TKSLQTPANMFIINLAFSDFTFSLVNFPLMTISCFKKWIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAA----SKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYT---LEGVLCNCSFDYDTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELNAEMRLAKISIVIVSQFLLSWSPYAVALLAQFGPVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPCCQ
64djhA 0.10 0.17 0.94 1.78Download -SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRY---TKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSD-------RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP--
74iarA 0.13 0.18 0.92 2.79Download ISLPWKVLLVMLLALITLATTLSNAFVIATVYR---TRKLHTPANYLIASLAVTDLLVSILVMPSTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIA----LVWVFSISISLPPFFWRQA------SECVV--N--T-DHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDDQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI----WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-
84buoA 0.12 0.20 0.94 2.19Download TDIYSKVLVTAIYLALFVVGTVGNSVTLFTLAR---KKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICH-------PFKAKTRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPITLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQ-----PGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL----
94djhA 0.10 0.17 0.93 1.55Download -SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIR----TKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKA----LDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSD-----------RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP--
103rzeA 0.12 0.17 0.87 1.55Download M------PLVVVLSTICLVTVGLNLLVLYA----VRSERKLTVGNLYIVSLSVADLIVGAVVMMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY----LKYRTKTRASATILGAWFLSFLWVIPILGWNHRREDKCETDFYDV--------TWFKVMTAIINFYLPTLLMLWFYAKIYKAV----------------RHMNRERKAAKQLGFIMAAFILCYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL--HI
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=0.05 (Read more about C-score)
  • Estimated TM-score = 0.72±0.11
  • Estimated RMSD = 6.1±3.8Å

  • Download Model 2
  • C-score = -2.68

  • Download Model 3
  • C-score = -4.61

  • Download Model 4
  • C-score = -5

  • Download Model 5
  • C-score = -4.75




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).