GO:1901363	F	0.70	heterocyclic compound binding
GO:0097159	F	0.70	organic cyclic compound binding
GO:0003677	F	0.67	DNA binding
GO:0043565	F	0.50	sequence-specific DNA binding
GO:0004871	F	0.41	signal transducer activity
GO:0003690	F	0.40	double-stranded DNA binding
GO:0000975	F	0.40	regulatory region DNA binding
GO:0005057	F	0.39	receptor signaling protein activity
GO:0003700	F	0.39	transcription factor activity, sequence-specific DNA binding
GO:0044212	F	0.38	transcription regulatory region DNA binding
GO:0005072	F	0.36	transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0000976	F	0.34	transcription regulatory region sequence-specific DNA binding
GO:0046983	F	0.31	protein dimerization activity
GO:0046982	F	0.26	protein heterodimerization activity
GO:0019899	F	0.26	enzyme binding
GO:0046332	F	0.25	SMAD binding
GO:0000981	F	0.25	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000977	F	0.25	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000987	F	0.24	core promoter proximal region sequence-specific DNA binding
GO:0008134	F	0.23	transcription factor binding
GO:0005102	F	0.21	receptor binding
GO:0044877	F	0.20	macromolecular complex binding
GO:0030618	F	0.20	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0000978	F	0.19	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0042802	F	0.18	identical protein binding
GO:0031625	F	0.17	ubiquitin protein ligase binding
GO:0070411	F	0.16	I-SMAD binding
GO:0003682	F	0.16	chromatin binding
GO:0070410	F	0.15	co-SMAD binding
GO:0003824	F	0.14	catalytic activity
GO:0042803	F	0.13	protein homodimerization activity
GO:0030616	F	0.13	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0070412	F	0.12	R-SMAD binding
GO:0046872	F	0.12	metal ion binding
GO:0005160	F	0.12	transforming growth factor beta receptor binding
GO:0001077	F	0.12	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
