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# D-I-TASSER results for O94832-D2

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>O94832 (412 residues) FVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYE RPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVER VKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIV QQPGEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQE QEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKL GKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKTAATLFKNSMIALVD NLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFR

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400
| | | | | | | | | | | | | | | | | | | |
FVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFR
Prediction
CCCCCCCCHHHHHHHHHHHHHCCCCSSSSCCSSSSSCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCSSSSSSCCCCCCCS HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCSSSCCCCCCCCSSSSSSSSSCCCCCSCCCSSSS HHHHHCSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCS HHHCCSSSSSCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCC
Confidence 9878879979999999999803982675635499977985368889999999828996679982899999999998742678089985567898621147799999885067887522568888987376421243114013688774258877663268815010532014330224675167421001111112223434433433332137610122453104678889976569999999992998522456781999998833876254776678732799865999999999965697655676456644321356631222123477741453554114788999889999999871475321045885335764357789999999832388887764268999
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 | | | | | | | | | | | | | | | | | | | | FVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFR
Prediction | 7350540216000300340056520000001000000002303211451053037363662200000002100421343431000000133342212003201200020123454433330231121001234332202022134422001000010243040110202200242010012132222222223322222221233221220431432120011024412310141004302510461615155041320320031014321000000141124234231420041026215624313344335454435454302143114303230430244443123203520340042024143232321433454314404461011001000000001001421157
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCCCCCCCHHHHHHHHHHHHHCCCCSSSSCCSSSSSCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCSSSSSSCCCCCCCS HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCSSSCCCCCCCCSSSSSSSSSCCCCCSCCCSSSS HHHHHCSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCS HHHCCSSSSSCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCC FVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFR
1 | 1g8xA | 0.40 | 0.39 | 11.59 | 1.50 | DEthreader |  | MSELSYLNEPAVFHN L RVRYNQDLI Y TYSGLFLVAV N PFKRIPI YTQEMVDIFK G RRRNEVAP HIF A ISDVA YRSMLDDRQNQSLLITG E S G A G K T ENTKKVIQ YLASVAGRNQANGSGVLEQQILQANPIL E A F G N A K TTR NNN S SEF G KFIEIQFNNAGFISGASIQSY L L E K S R VDAKALYGFLWVKNCSERKAYFI G V L D ISG F E I FKVN S F E QLC I N YTN E K L Q QFFNHHMFKVE Q E E YLKEKINWTFIFGLDSQATID LIDGRQPG ILALL DEQSVFP-NAT DNTLITKLHSHFSKNAKYEEP--------RFSKTEFGVTH Y A GQVMYEIQDWLEK N K TVAAQYKEQLASLMATLETTNPHFV R C IIP NNKQLPAKLEDKVVLDQLRCNGVL EGIRITRKG FPNR
2 | 4byfA1 | 0.59 | 0.58 | 16.64 | 3.23 | SPARKS-K |  | F V LLNFTSEAAFIEN L RRR FRENLI Y TYI GPVLV S V N P YRDLQI YSRQHMERYRGVSFY EVP P H L F AVA DTVYRALRTERRDQAVMI S G E S G A G K T E ATKRLLQFYAETCPAPERGG--AVRDRL LQS NPV L E A F G N A K TLR N D N S S R F G K Y M DVQF D F K GAPVG G H ILSY L L E K S R VVHQNHG ELSPLNSPSWRSTT VLGLL D I Y G F EVFQHN S F E Q F C I N Y C N E K L Q Q L F IELTL KSE Q E E YEAE G IAWEPVQY F N NKI ICD L V EEKFK G I ISI L DEECLRPGEAT DLTF L EKLEDTVKHHPH FLTHK L--ADRKSLGRGEF RLLH Y A GEVTY S VTG FLD K NNTVA TQF KMSLLQL VEILQS K E PAY V R C I K P N DAKQPGRF DEVLIR H Q VKY L G L L E NLR V R R A G----
3 | 6ui4A | 0.51 | 0.49 | 14.14 | 1.39 | MapAlign |  | LTLLSKV SNEAINEN LKKR F EGREI Y TYI GHVLV S V N PFRDLGI YTDDVLQSYMGKNRLEMP P HVF A I AEASYYNM KAYSDNQCVII S G E S G A G K T E AAKRI M Q Y I ASVSGGES-GDIKQIKDMVLATNPLL ESF G N A K TLR NNN S S R F G K YLQIYFNTQGEPVGADITN Y L L EYSNLFDWIVERINKSLKARQPTTNTI GIL D I Y G F E I FEKN S F E QLC I N YVN E K L Q QIF I Q LTL KAE Q E E YAR EQIQWTPIKY FDNKVVCD LIE QIPVG IFSAMKD ATADPAAC-DRTFMQSINGM--SH A HLTPR-----------QGNFIIKH Y A G D VTYTVEGITD K N KSAGDRIRASANA L V DTLMKCQPSYIRTI K P NENK S PTEYNGPNVLH QIKY L G LQE N V RIR R A G F AYR
4 | 6ui4A | 0.52 | 0.50 | 14.40 | 0.74 | CEthreader |  | LTLLSKV SNEAINEN LKKR F EGREI Y TYI GHVLV S V N PFRDLGI YTDDVLQSYMGKNRLEMP P HVF A I AEASYYNM KAYSDNQCVII S G E S G A G K T E AAKRI M Q Y I ASVSGGESG-DIKQIKDMVLATNPLL ESF G N A K TLR NNN S S R F G K YLQIYFNTQGEPVGADITN Y L L E K S R VVGQITNEINKSLKARQPTTNTI GIL D I Y G F E I FEKN S F E QLC I N YVN E K L Q QIF I Q LTL KAE Q E E YAR EQIQWTPIKY FDNKVVCD LIE QIPVG IFSAMKD ATKTAPAACDRTFMQSINGM--SH A HL-----------TPRQGNFIIKH Y A G D VTYTVEGITD K N KSAGDRIRASANA L V DTLMKCQPSYIRTI K P NENK S PTEYNGPNVLH QIKY L G LQE N V RIR R A G F AYR
5 | 4byfA1 | 0.59 | 0.58 | 16.51 | 2.32 | MUSTER |  | F V LLENFSEAAFIEN L RRR FRENLI Y TYI GPVLV S V N P YRDLQI YSRQHMERYRGVSFY EVP P H L F AVA DTVYRALRTERRDQAVMI S G E S G A G K T E ATKRLLQFYAETCPAPERGG--AVRDRL LQS NPV L E A F G N A K TLR N D N S S R F G K Y M DVQF D F K GAPVG G H ILSY L L E K S R VVHQNHGTLRRLGSPSWRSTT VLGLL D I Y G F EVFQHN S F E Q F C I N Y C N E K L Q Q L F IELTL KSE Q E E YEAE G IAWEPVQY F N NKI ICD L V EEKFK G I ISI L DEECLRPGEAT DLTF L EKLEDTVKHHPH FLTHK L--ADRKSLGRGEF RLLH Y A GEVTY S VTG FLD K NN-VA TQF KMSLLQL VEILQS K E PAY V R C I K P N DAKQPGRF DEVLIR H Q VKY L G L L E NLR V R R A G----
6 | 1g8xA | 0.41 | 0.40 | 11.86 | 2.44 | HHsearch |  | MSELSYLNEPAVFHN L RVRYNQDLI Y TYSGLFLVAV N PFKRIPI YTQEMVDIFK G RRRNEVAP HIF A ISDVA YRSMLDDRQNQSLLITG E S G A G K T ENTKKVIQ YLASVAGRNQANGSGVLEQQILQANPIL E A F G N A K TTR NNN S SEF G KFIEIQFNNAGFISGASIQSY L L E K S R VVFQSETERKKINLCSERKAYFI G V L D ISG F E I FKVN S F E QLC I N YTN E K L Q QFFNHHMFKVE Q E E YLKEKINWTFI DFLDSQATID LIDGRPPG ILALL DEQSVFPNA-T DNTLITKLHSHFSKNAKYEEPRF--------SKTEFGVTH Y A GQVMYEIQDWLEK N K TVAAQYKEQLASLMATLETTNPHFV R C IIP NNKQLPAKLEDKVVLDQLRCNGVL EGIRITRKG FPNR
7 | 4byfA1 | 0.59 | 0.58 | 16.51 | 3.93 | FFAS-3D |  | F V LLEFTSEAAFIEN L RRR FRENLI Y TYI GPVLV S V N P YRDLQI YSRQHMERYRGVSFY EVP P H L F AVA DTVYRALRTERRDQAVMI S G E S G A G K T E ATKRLLQFYAETCPAPERGG--AVRDRL LQS NPV L E A F G N A K TLR N D N S S R F G K Y M DVQF D F K GAPVG G H ILSY L L E K S R VVHQNHG ERNFHIFYSWRSTT VLGLL D I Y G F EVFQHN S F E Q F C I N Y C N E K L Q Q L F IELTL KSE Q E E YEAE G IAWEPVQY F N NKI ICD L V EEKFK G I ISI L DEECLRPGEAT DLTF L EKLEDTVKHHPH FLTHK LADRKSL--GRGEF RLLH Y A GEVTY S VTG FLD K NNDVA TQF KMSLLQL VEILQS K E PAY V R C I K P N DAKQPGRF DEVLIR H Q VKY L G L L E NLR V R R A G----
8 | 4l79A | 0.58 | 0.58 | 16.59 | 1.63 | EigenThreader |  | TV LLEPLNEETFIDN LKKR FDHNEI Y TYI GSV VIS V N P YRSLPI YSPEKVEDYRNRNFY ELSP HIF ALSDEA YRSLRDQDK DQC ILITG E S G A G K T E A S KLVMSYVA AVCGK--GA E VNQV KEQL LQSTPV L E A F G N A K TVR N D N S S R F G K Y M D IEF D F K G D PLG GVISN Y L L E K S R VVKQPRG ERNFESIKAQTKVRKMG V L D I Y G F E I FEDN S F E Q FII N Y C N E K L Q QIF IELTL KEE Q E E YIR EDIEWTH I D Y F N NAI ICD LIENNTNG ILAML DEECLRPGTV T D ETF L EKL NQVCATHQHESRMSKCRFLNDTTLPHSCR IQH Y A GKVLYQVEG FVD K NNT AGSQF KASVATLMKN LQTKNPNYIR C I K P N D K KAAHI FSESLVCH QIRY L G L L E N V R V R R A GYA F R
9 | 1lkxA | 0.56 | 0.55 | 15.86 | 3.19 | CNFpred |  | F V LLNQITENAFIEN LTMRHKSDNI Y TYI GDV VISTN PFKNL N I YKESDIKAYNG RYKY EMP P HMYALANDA YRSMRQSQENQCVII S G E S G A G K T E A S KKI M QFLTFVSSN-QSPNGE RISKM L LDS NPLL E A F G N A K TLR N D N S S R F G K Y MEMQFNAVGSP I G GKITN Y L L E K S R VVGRTQG ERGCFDVST-EKGPV I GIL D I Y G F EVFQN N S F E QLNI NFC N E K L Q Q L F IELTL KSE Q E E YVR E G IEW KNIEY F N NKPICELIEKKPIGLISLL DEA CLIA-KST DQTF LDSICKQFEKNPHLQSYVVSKDRSIG--DTCF RLKH Y A G D VTYDVRG FLD K N K T AGSQFRNAMNA LITTLLACSPHY V R C I KSN DNKQAGVIDEDRVR H Q VRY L G L L E N V R V R R A G F AGR
10 | 4l79A | 0.58 | 0.57 | 16.46 | 1.50 | DEthreader |  | VDVLLEPLNETFIDN LKKR FDHNEI Y TYI GSV VIS V N P YRSLPI YSPEKVEDYRNRNFY ELSP HIF ALSDEA YRSLRDQDK DQC ILITG E S G A G K T E A S KLVMSYVA AVC-G-KGA E VNQV KEQL LQSTPV L E A F G N A K TVR N D N S S R F G K Y M D IEF D F K G D PLG GVISN Y L L E K S R VVDAKLYSFSWVNNKAKVRKKVMG V L D I Y G F E I FEDN S F E Q FII N Y C N E K L Q QIF IELTL KEE Q E E YIR EDIEWTH I D Y F N NAI ICD LIENNTNG ILAML DEECLRPGTV T D ETF L EKL NQVCATHQH FES RSKCRFLDTTLPHSCF R IQH Y A GKVLYQVEG FVD K NNT AGSQF KASVATLMKN LQTKNPNYIR C I K P N D K KAAHI FSESLVCH QIRY L G L L E N V R V R R A GYA F R
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.8257
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 4byfA | 0.98 | 0.94 | 0.583 | 0.990 | model1_4byfA.pdb.gz
| 2 | 1lkxC | 0.97 | 1.06 | 0.536 | 0.988 | model1_1lkxC.pdb.gz
| 3 | 2ycuA | 0.96 | 1.39 | 0.415 | 0.983 | model1_2ycuA.pdb.gz
| 4 | 5i0hA | 0.95 | 1.20 | 0.418 | 0.976 | model1_5i0hA.pdb.gz
| 5 | 6ui4A | 0.95 | 0.92 | 0.513 | 0.966 | model1_6ui4A.pdb.gz
| 6 | 4zg4E | 0.95 | 1.12 | 0.440 | 0.966 | model1_4zg4E.pdb.gz
| 7 | 6ycxA | 0.93 | 1.69 | 0.354 | 0.973 | model1_6ycxA.pdb.gz
| 8 | 6dueA | 0.93 | 1.73 | 0.362 | 0.973 | model1_6dueA.pdb.gz
| 9 | 1g8xA | 0.90 | 2.52 | 0.382 | 0.976 | model1_1g8xA.pdb.gz
| 10 | 6qdjA | 0.89 | 2.54 | 0.373 | 0.968 | model1_6qdjA.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0017111 | 0.94 | nucleoside-triphosphatase activity
GO:0005524 | 0.90 | ATP binding
GO:0003774 | 0.90 | motor activity
GO:0005516 | 0.89 | calmodulin binding
GO:0000146 | 0.86 | microfilament motor activity
GO:0016887 | 0.84 | ATPase activity
GO:0042623 | 0.82 | ATPase activity, coupled
GO:0030898 | 0.79 | actin-dependent ATPase activity
GO:0008092 | 0.64 | cytoskeletal protein binding
GO:0003779 | 0.62 | actin binding
GO:0042802 | 0.59 | identical protein binding
GO:0042803 | 0.58 | protein homodimerization activity
GO:0032403 | 0.53 | protein complex binding
GO:0051015 | 0.52 | actin filament binding
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0044699 | 0.91 | single-organism process
GO:0009987 | 0.85 | cellular process
GO:0044763 | 0.78 | single-organism cellular process
GO:0051179 | 0.69 | localization
GO:0016043 | 0.66 | cellular component organization
GO:0006810 | 0.66 | transport
GO:0032502 | 0.64 | developmental process
GO:0044767 | 0.63 | single-organism developmental process
GO:0030029 | 0.63 | actin filament-based process
GO:0016192 | 0.61 | vesicle-mediated transport
GO:0006928 | 0.60 | movement of cell or subcellular component
GO:1902578 | 0.59 | single-organism localization
GO:0065007 | 0.59 | biological regulation
GO:0044765 | 0.58 | single-organism transport
GO:0006897 | 0.58 | endocytosis
GO:0050789 | 0.57 | regulation of biological process
GO:0032501 | 0.57 | multicellular organismal process
GO:0030048 | 0.56 | actin filament-based movement
GO:0048856 | 0.55 | anatomical structure development
GO:0006909 | 0.55 | phagocytosis
GO:0044351 | 0.54 | macropinocytosis
GO:0003008 | 0.52 | system process
GO:0050794 | 0.50 | regulation of cellular process

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0016459 | 1.00 | myosin complex
GO:0043226 | 0.92 | organelle
GO:0044444 | 0.90 | cytoplasmic part
GO:0043229 | 0.85 | intracellular organelle
GO:0005737 | 0.77 | cytoplasm
GO:0043227 | 0.58 | membrane-bounded organelle
GO:0042995 | 0.56 | cell projection
GO:0043232 | 0.55 | intracellular non-membrane-bounded organelle
GO:0031982 | 0.52 | vesicle
GO:0031988 | 0.51 | membrane-bounded vesicle

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 1e1yA | 0.369 | 6.62 | 0.074 | 0.585 | 2.4.1.1 | NA
| 2 | 0.060 | 3g0bB | 0.375 | 6.73 | 0.042 | 0.592 | 3.4.14.5 | 99
| 3 | 0.060 | 1fa9A | 0.372 | 6.75 | 0.069 | 0.600 | 2.4.1.1 | NA
| 4 | 0.060 | 3gpbA | 0.355 | 6.87 | 0.031 | 0.578 | 2.4.1.1 | NA
| 5 | 0.060 | 1gojA | 0.411 | 4.87 | 0.106 | 0.532 | 3.6.4.4 | 207
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.83 | 2v26A | 0.939 | 1.75 | 0.395 | 0.971 | 1.31 | UUU | complex1.pdb.gz | 25,37,38,39,91,92,93,94,95,96,97,101,143,146,147,206,207
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

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References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.