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# D-I-TASSER results for P02458-D1

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>P02458 (1384 residues) MIRLGAPQTLVLLTLLVAAVLRCQGQDVQEAGSCVQDGQRYNDKDVWKPEPCRICVCDTG TVLCDDIICEDVKDCLSPEIPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPKG PPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFA AQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMG PRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKG EAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVG PAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKG SAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQG APGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAG PKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPG VMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPG PSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRG LPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPG KDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPG ADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPG AAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPG DDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPG PVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAG PTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKDPLQYMRADQ AAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPN QGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGD DNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRA EGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGP VCFL

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380
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Prediction
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCSSSCCSSCCCCCCCCCCCCCSSSCCCCCSS SSCCCCCSCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCHHHHHHHCCCCCCCCCCCSSSSSCCHHHHHCCCCCCCCCCCSCCCCCCCSSCCCCCCCSSSSSSCCCCSCCCCCCSSSSSSSSCCCCCCCCCSSSSCCCCCCCCCSSSSSSCCCCCC
Confidence
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Prediction |
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCSSSCCSSCCCCCCCCCCCCCSSSCCCCCSS SSCCCCCSCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCHHHHHHHCCCCCCCCCCCSSSSSCCHHHHHCCCCCCCCCCCSCCCCCCCSSCCCCCCCSSSSSSCCCCSCCCCCCSSSSSSSSCCCCCCCCCSSSSCCCCCCCCCSSSSSSCCCCCC
1 | 1vt4I | 0.25 | 0.18 | 5.71 | 0.59 | CEthreader |  | CNSPETVLEMLQKLLYQIDPNWTSRSDHSSNIKLRIHSIQAELRRLLKSKPYENCLLVLLNVQNAKAWNAFNLSCKILLTTRFKQVTDFLSAATTTHISLDHHSMTLTPDEVKSLLLKYLDCRP QDLPREVLTTNPRRLSIIAESIRDGLATWDNWKHVNCDKLTTIIESSLNVLEPAEYRKMFDRLSVFPPSAHIPTILLSLIWFDVIKSDVMVVVNKLHKYSLVEKQPKESTISIPSKLENEYALHRSIVDHYNIPKTFDSDDLIP PYLDQYFYSHIGHHLKNIEHPERMTLFRMVFLDFRFLEQKIRHDSTAWNASGSILNTLQQLKFYKPYICDNDPKYERLVNAILDFLPKIEENLICSKYTDLLRIALME AHKQVQR GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--------GGGGGGGGGGGGGGGG--------------------------G GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-----GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--------GGGGGGGGGGGGGGGGGGGGGGGGG-----------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-----GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 | 1xi5A | 0.05 | 0.04 | 1.77 | 1.50 | EigenThreader |  | PDQGQQFAQMLVQDEQIVDVFMEYNLICTAFLLDALKNNRPSEG--------------------PLQTRLLEMNLMHA----------PQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQL-----------STQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVR GQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVH----------------------------ADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLD ASESLRKEEEQATETQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3 | 3hr2A | 0.30 | 0.20 | 6.04 | 1.60 | FFAS-3D |  | --------------------------------------------------------------------------------------------------------------------MSYGYDEKSAGVSVPG PMGPSGPRGLGPGAG PQGFQGPGEGEGGSG PMG P P G PGPGKN-----------------------------GDDGEAGKP GRGERP G P Q GARGLGTAGLGMGHRGFSGLDGAKGDTGPAGPKG EGSGENGTGQMG PRGLGERGRGP G TAGARGNDGAVGAAGPGPTGPTGPGFGAAGAKGEAGPQGARGSEG PQGVRG EGP--G P A G A A GPAG NGADGQGAKGANGAGIA GAGFGARGPSGPQGPSGAGPKGTSGEGAGNKGDTGAKGEG P A GVQG-P GPAGEEGKRGARGEGPSGLGP GERGGSRGFGADGVAG PKG PSGERGSGPAGPKGSGEAGRG EAGLGAKGLTGSGSGPDG KTGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPA GKDGEAGAQG-AGPAGPAGER GEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERG FGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGA GLQGMERGAAGLGPKGDRGDAGPKGADGSP GKDGVRGLTGPIGPPAGA GDKGEAG PSGPAGPTGAR GAGDRGEAPG PAGFAGPGADGQGAKGEGDTGVKGDAG PGPAGPAGPGPIGNVGA G PGSRGAAGPGATGFG AAGRVGPGPSGNAGPGP G PVGKEGGK GPRGETG P A GRGEVGPGP GPAG EKGSGADGPAGSGTPGPQGIAGQRGVVGLG QRGKRGFGLGPSGEGKQG PSGASGERG PGPMGPGLAGP GESGREGSGAEGSGRDGAGAKGDRGETG PAGPGAGAG APGPVG PAGKNGDRGETG P A G PAGPIGPAGARG PAGPQG PRGDGETGEQ-----GDRGIGHR G FSG LQG PGSGSGEQ GPSG A S GPAG PRG PGAGSGKDGLNGLGPIGGPRGRTGDSGPAGPGPGPGPGPPSGGYDFSFLPQP PQEKSQDGGRY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 | 3gavA | 0.12 | 0.10 | 3.57 | 2.32 | SPARKS-K |  | -------------------------------------------------------------------------------------------------------EDCNELPPRRNTEILTGSWSDQTPEGTQAIKCRPGYRSL-GNVIMVCRKG EW-VALN PLRKCQKRPCGHP GDTPFGTFTLTG GNVFEYGVAVYTCNQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEIVSSAMEPDREYHFGQAGYKIEGDEEMHDGFWSKEKPKCVEISCKSP--DVINGSPISQKIIYKENEKCNMGYEYSERGDTESGRPLPSCEEKSDNPYIPNGDYSPLRIKHRTGDEITQCRNGFYPATRGNTAKCTST-------GWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGK-----YYSYYCDEHFETPSGS---YWDHIHCTQDGWSPAVPCLR--KCYFPYLENGYNQNHGRKFVQGKSIDVACHP-----GYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAK-----YQCKLGYVTADGETSGSITCGKD GWSAQP--------TCIKSCDIPVFMNARTKNDFTWFKLN-DTLD-YECHD GYESN-TGSTTGSIVCGYNGWSDLPICYERECELPKIDVHPDRKKDQYKVGEVLKFSCKFTIVGPNSVHFGLSPDLPICKEQVQSCGPPPELLNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQL-------PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGWDPEVNCSMAQIQLCP PPPQIPNSHNMTTTLNYRD GEKVSQENYLIQEGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK--WSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTFEGFGID GPAIAKCLGEKWSHPPIKTDCLSLPSFENAIPMGEKKDVYKA GEQTCATYYKMDG ASNVTCINSRWTGRPTCRDTSCVNPPTV--------QNAYIVSRQMS-------------KYPSRSPMFGDEEVMCLNGN-----WTEPPQCKDSTGKC-------------------GPPPPIDNGDITSFPLSVYAP-------ASSVEYQCQNLYQLEGNKRITCR-----QWSEPPKCLHPCVISREIMENYNIALRQKLYSRTGESV EFVCKRGYR-----LSSRSHTLR--------TTCWDGKLEYPTCAKR---------------------
5 | 3hqvA | 0.68 | 0.46 | 13.00 | 9.96 | CNFpred |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G P M G PSG P R GLMG PMG AMG P Q G F Q GPMG EMG EMGGS G P M G PPG PMG PMG KNG D D G E A G K P GRMG E R G PMG P Q G A R GLMG TAG LMGMMG H R GFSG L D G A K GDTGPAGPK G EMG SMG E N GTMGQM G P R G LMG E R G RMG PMGTA G A R G N D GAVGAA G PMG PTG PTGPMG FMG AAG A K G E A G PQG A R GSE GPQ GVR G EMGPMGPAGAA GPAG NMGAD GQMG A K GANG AMG I A G AMG FMGAR G PSG P Q GPSGAMG P K GTSG EMGAMGNK GDTGAK G EMG P A GVQ GPMG P A G E E G K R G A R G EMGPSGLMG PMG E R GGMGSR G FMGAD GVA G P K GPSG E R GSMGPA G P K GSMGEAG RMG EAG LMG AKG L T GSMGSMG PDG KTG PMGPAGQD G RMG PAG PMG A R G QAG V M G FMG P K GTAG EMG K A G ERGVMGPMGAVGPAG K D G EAG AQGAMG P A G P A G E R G E Q GPAGSMG F Q G LMG PAG PMG EAG KMGEQ G VMGDLG AMGPSGAR G E R G FMG E R GVQGPMGPAG P R GNNGAMGND GAK GDTGAMGAMGSQ GAMG L Q G MMG E R G A A GLMG P K G D R G DAGPK GADGSP G K D GVR G L T G P I G PMG P A G AMGDK G EAG PSG P A GPTG A R G AMGDR G EAG PMG P A G F A G PMG A D G QMG A K G EMGDTGVK G D A GPMG PAG PAGPMG PIGNVGAMG PMGSR G AAG PMG A T G FMG A A G R V G PMGPSG NAG PMG PMG PVG KEGGK GPR GETG PAG RMG EVGPMG PMG PAG E K GSMGAD G PAGSMGTP G P Q GIA G Q R GVV G LMG Q R GKR G FMG LMG P S G EMG K Q GPSG A S GER G PMG PMG PMG LAG PMG ESG R E G SMG AEGSMG R D G AMGAK G D R G E T GPAGPMG AMGAMGAP G PVG PAG KNG D R G ETGPAG PAG PIG P A G A R GPAG P Q G P R G DMG ETG EQGDR GI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 | 3cmuA | 0.06 | 0.02 | 0.98 | 0.33 | DEthreader |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTGEQALEICDAL--IVVDSVAALT---------IGDS-MG-A---MLLIFINQI--T---------------EG-D-KQALAAALGQIEKQFGKGSI-MRLGE---D-RSMDVE---T-----I-TGSLSLDIALGAGGLPMGRIVEIYG----------------QREGKTC----------VDIDNLLC------EQALEICD-LARSGAVDVIVVVALTPKA--------HMGLAARMM--A---------------IFINQIRMKI-V----PETTTGG-------IRRS-Y-------GSIMRLGEDRSMDV--------IALGAGGLPIGKTTLTLQAALDPIYARKLGVDIDNLLCSALEIDPKAEHGLARMMSAMR---------LIFINQIRTTTGGNALYASVNKIA-----E------KGE-ILDNPETAKE--AIDENKQKALALQIEQFG--------------RIE-LEICDALAIVVLIFIIRRIGAVKENVVGSETRVKVVQAEFQILYGEGINFYGELVDA-YGQGKANATAWLK-V-IALG---LPGRIVEIYGPESSGKTTEHAAATEIEGEI--FGKGSIMRLGEDR---S----MDV---ETISTGSLSLDIALGAG---------------------SGKTTLTLQV-------AEHA----QPDTGEQALICLAVIVVDSVA-LTPMGLAARMMSAMRKLGNLKNTLLIFINTG--------------------------------------------------------------------------------------------------------------------------------------------------------
7 | 4om9A | 0.06 | 0.04 | 1.64 | 1.61 | MapAlign |  | -------MDISKAWARDYLDLAQNKGVFQPGSTHVKIKLKDFSFPALPVPDFSSATANGAATSIGGAYAVTVAHNAKNKSSANYQTYGSTQYTQ---INRMTTGNDFSIQRLNKYVVETRGADTSFNYNENNQNIIDRYGVDVGNGKKEIIGFRVGSGNTTFSGIKTSQTYQADLLSASLFHITNLRANTVG GNKVEYE------NDSYFTNLTTNGDSGSGVYVFDNKEDKWVLLGTT----------------HGIIGNGKTQKTYVTPFDSKTTNELKQLFIQNVNIDNNTATIGGGKITNKDLVFSGGG--------------------------------------------------------------------------------------------------KISLKENLDLGYGGFIFDENKKYTVSAEGNNNVTFKGAGIDIGKGSTVDWNI-----------------------------------------------------------------KYASNDALHKIGEGSLNVIQAQNTNLKTGNGTVILGAQK-----------------------------------------------TFNNIYVAGGPGTVQLNAENA------------------------------------------------------------------------------------------------LGEGDYAGIFFTENGGKLDLNGHNQTFKKIA-------------------------------------------------------------------------------------------ATDSGTTITNSNTTKESVLSVNNQNNYIYHGNVDGNVRLEHHLDTK--------------------QDNARLILDGDIQANSISIKNAPLVMQGHATDHAIFRTTKTNNCPEFLCGVDWVTRIKNA-ENSVNQKNKTTYKSNNQVSDLSQPDWETRKFRFDNLNIEDSSLSIARNANIQAKNSVINIGDKTAYIDLYSGKNITGAGFTFRQDIKSGDSIGESKFTGGIMATDGSISIGDKAIVTLNTVSSLDRTALTIHKGANVTASSSLFTTSNIKSGGDLTLTGATESTGEITFYAAGGYELTEDGANFTAKNQASVTGDIKSEKAAKLSFLAMLDGFDTSYQGSIKAAQSSLAMNNALWKVTGNSELKKLNSTGSMVLFNGGKNIFNTLTVDELTTSNSAFVMRTNTQQADQLIVKNKLEGANNLLLVDFIEKKGNDKNLNIDLVKAPENTSKDVFKTETQTIGFSDVTPEIKQQEKDGKSVWTLTGYKTV-------------------------------------
8 | 3hr2B | 0.57 | 0.36 | 10.25 | 2.96 | MUSTER |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKGVSAGPG P M GLM G P R G-P GAVG-AG P Q G F Q GPAG EG--EGQTG PAGSR G PAG-P G KAGED GH-G K P G-RG E R GVVG P Q G A R G FGTGLG----FGIR GHNG L D GLK GQGA----QGVGEGAG E N G-TGQAGAR G L-G E R G RVGA-GPA G A R GSD GSVG PVG PAG PIGSA G----P GFGAGPG ELG PVGN-G PAGPAG P R G EAG-LGLSG PVG-PG N P GANGLTG A-GATG-LGVA G A--GLG P R G-IG PVG AAGATG PRGLVG E-GPA GS-G ETGNK G E-GSA GAQ G-P G PSG E E G K R GSPG E P GSAG PAG-P GLR G-SGSR GL-GAD GRA GVMGPP GNR GSTGPA GVRGPN G DAG RG--EG LMGPR G L--GSGNVG PAG KEG PVG-LGID G-RG PIG PAGPR GEAGNIG F-G P K GPSGD--GKG E K GHP GLAGAR G-AGPD GNNG AQG-P G PQGVQGGKG E Q GPAG P-G F Q G L-G PSGTAG EVG K-GERGLP G EFG-LGPAG P R G E R G-P G ESGAAGPSGPIGIR GPSG-AGPD GNK GEAGAVGAP GSAGASGPGGL-G E R G A A G-IGGK GEKGETGLRGEIGNP GRD GAR GA-GAI G-AG P A G ASGDRG EAGAAG PSGPA GPR GSP G E R G EVG PAG PNG F A G PAGSAG QG--AG EKGTKGPK GENGIVG PTG PVG AAG PSG PNGPPG PAGSR GDGG P P GMT G F-G A A G RTG-P GPSGITG PG--P GAAG KEGIRGPR G DQG PVG RTG EIGASG PPGFAG E K GPSGEGTTPGTAG PQGLLGIA GALG-AGEAGRDGNIGPTGAAGAPGPHGSVGPAGKHGNR GEP G PAGSVGPVGAVGPRGPSGPQGIRGDKGEPG ARGLPGLKGHNGLQGLP GLAGLHGDQGAPG PVGPAGPR GPA GPSG PIGKDGRSGHPGPVG PAGVR GSQGSQGPAGPGP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9 | 3hr2A | 0.68 | 0.46 | 13.00 | 5.85 | HHsearch |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q MSYGYD E KS---AGVSVPG P M G PSG P R GLG---PGAG P Q G F Q GPGEG---EGGS G P M G PPG PG--P G KNG D D G E A G K P GR-G E R G-P G P Q G A R GL-G TAG L-G-MG H R GFSG L D G A K GDTGPAGPK G EG--SG E N G-TGQM G P R G L-G E R G RG--PGTA G A R G N D GAVGAA G P-G PTG PTG-P G F-G AAG A K G E A G PQG A R GSE GPQ GVR G EG--P GPAGAA GPAG N-GAD G-QG A K GANG A-G I A G A--GFGAR G PSG P Q GPSGA-G P K GTSG EG--A GNK GDTGAK G E-G P A GVQ G-P G P A G E E G K R G A R G EGPS-G--LGP G E R GG-GSR G F-GAD GVA G P K GPSG E R G-S GPA G P K GS-GEAG R-G EAG L-G AKG L T GSG--SG PDG KTG P-GPAGQD G R-G PAG-PG A R G QAG V M G F-G P K GTAG E-G K A G ERGV--GP GAVGPAG K D G EAG AQG-AG P A G P A G E R G E Q GPAG-S G F Q G L-G PAG-P G EAG K-GEQ G V-GDLG A-GPSGAR G E R G F-G E R GVQGP-GPAG P R GNNGA-GND GAK GDTGA--GAGSQ G-AG L Q G M-G E R G A A GL-G P K G D R G DAGPK GADGSP G K D GVR G L T G P I G P-G P A G A-GDK G EAG PSG P A GPTG A R G A-GDR G EAG P-G P A G F A G P-G A D G Q-G A K G E-GDTGVK G D A G-P G PAG PAG-P G PIGNVGA-G-PGSR G AAG-P G A T G F-G A A G R V G P-GPSG NAG PG--P G PVG KEGGK GPR GETG PAG RG-EVGP--GPG PAG E K GS-GAD G PAGS-GTP G P Q GIA G Q R GVV G L-G Q R GKR G F-G L-G P S G E-G K Q GPSG A S GER G P-G PMG P-G LAG P-G ESG R E G SG-AEG-SG R D G A-GAK G D R G E T GPAGPGAGA---GAP G PVG PAG KNG D R G ETGPAG PAG PIG P A G A R GPAG P Q G P R G D-G ETG EQGDR GI-GH----RGFSGLQGPGSGSGEQG---------PSGASGPAGPRGPG-SA--------GSGKDGLNGLGP-IG----GPR----GRT GDSGPGP-GPGPP-----------------SGG--------------------YDFSF LPQPPQKSQ--------DGGRYY---------------------------------------------------------------------------------------
10 | 4m5dA | 0.07 | 0.05 | 2.08 | 0.51 | CEthreader |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TATESYDIHIARETAELFKSNIFKLQIDELLEQVKLKQKHVLKVEKFLHKLYDILQEIPDWEEKSLAEVDSFFKNKIVSVPFVDP---------------------------KPIPQNTNYKFNYKKPDISLIGSFALKAGIYQPNGSSIDTLLTMPKELFEKKDFLNFRCLHKRSAYLTHHLLILLKKDKLDSFLQLEYSYFDNDPLLPILRISCSKDYNFYKTRFSINLLIGF-----PYKVFEPKKLLPNRNCIRILPATPLYNFSVLSSSTHENYLKYLYKTKKQTESFVEATVLGLQQR GFSSNMSHSGSLGGFGTFEFTILMAALLNGGGINSNKILLHGFSSYQLFKGVIKYLATMDLCGHLQFHSNPASKYIDEGFQTPTLFDKSTKVNILTKMTVSSYQILKEVVQDQFSNIFLTNISRFDNLKYDLCYDVQLPLGKYNNLETSLAATFGSMERVKFITLENFLAHKITNVARYALGDRIKYIQIEMVGQKSDFPITKRKVYSNTGGNHFNFDFVRVKLIVNPSECDKLVTKG PAHSETMSTEAAVIKSSLRRFKDGSITHCCVWSTSSSEPIISSIVNFALQKHVSKKAQISNETIKKFHNFLPLPNLPSSAKTSVLNLSSFFNQMKLPLSVKSILPVGSAFRYTSLCQPVPFAYSDPDFFQDVTSPKWPDEITSLEKAKTAFLLKIQEELSANSSTYRSFFSRDESIPYNLEIVTLNILTPEGYGFKFRVLTERDEILYLRAIANARNELKPELEATFLKFTAKYLASVRHTRTLENISHSYQFYSP--------VVRLFKRWLDTHLLLGHITDELAELIAIKPFVDPAPYFIPGSLENGFLKVLKFISQWNW KDDPLILDLVKPEERLTLAQYKGIQMNFTNLRNSDPNGTHLQFFVASKNDPSGILYSSGIPLPIALAKVAVN LLQTHGLNQQTINLLFTPGLKDYDFVVDLRTPIGLKSSCGILSAPSNFPENLNDLSEKMDPTYQLVKYLNLKYKNSLILSSRKYIGVNGGEKGDKNVITGLIKPLFKGAHKFRVNLDCNVKP
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.5066
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 6vr4A | 0.30 | 9.84 | 0.039 | 0.464 | model1_6vr4A.pdb.gz
| 2 | 2vdcA | 0.29 | 9.70 | 0.038 | 0.434 | model1_2vdcA.pdb.gz
| 3 | 1llwA | 0.28 | 9.71 | 0.056 | 0.431 | model1_1llwA.pdb.gz
| 4 | 6r9tA | 0.26 | 9.98 | 0.034 | 0.404 | model1_6r9tA.pdb.gz
| 5 | 5dotA | 0.26 | 10.02 | 0.030 | 0.405 | model1_5dotA.pdb.gz
| 6 | 6v85A | 0.26 | 9.51 | 0.037 | 0.387 | model1_6v85A.pdb.gz
| 7 | 6rc9A | 0.26 | 9.94 | 0.038 | 0.397 | model1_6rc9A.pdb.gz
| 8 | 7k10A | 0.26 | 9.74 | 0.021 | 0.391 | model1_7k10A.pdb.gz
| 9 | 5yz0A | 0.25 | 10.00 | 0.028 | 0.396 | model1_5yz0A.pdb.gz
| 10 | 6hq6A | 0.25 | 9.48 | 0.045 | 0.384 | model1_6hq6A.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0005198 | 0.51 | structural molecule activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0044699 | 0.91 | single-organism process
GO:0009987 | 0.79 | cellular process
GO:0044763 | 0.72 | single-organism cellular process
GO:0032502 | 0.68 | developmental process
GO:0065007 | 0.62 | biological regulation
GO:0044767 | 0.59 | single-organism developmental process
GO:0050789 | 0.58 | regulation of biological process
GO:0048856 | 0.57 | anatomical structure development
GO:0008152 | 0.53 | metabolic process
GO:0071704 | 0.52 | organic substance metabolic process

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 0.91 | cell part
GO:0044424 | 0.87 | intracellular part
GO:0044421 | 0.67 | extracellular region part
GO:0043234 | 0.66 | protein complex
GO:0044446 | 0.57 | intracellular organelle part
GO:0043226 | 0.56 | organelle
GO:0043227 | 0.54 | membrane-bounded organelle
GO:0044444 | 0.53 | cytoplasmic part
GO:0043229 | 0.51 | intracellular organelle

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 1bglA | 0.230 | 9.17 | 0.033 | 0.338 | 3.2.1.23 | NA
| 2 | 0.060 | 2uv8G | 0.224 | 9.89 | 0.024 | 0.344 | 2.3.1.86 | NA
| 3 | 0.060 | 1ug9A | 0.188 | 9.15 | 0.037 | 0.279 | 3.2.1.70 | 958
| 4 | 0.060 | 2pffA | 0.216 | 10.12 | 0.023 | 0.340 | 2.3.1.41 2.3.1.86 | 1087
| 5 | 0.060 | 2fhcA | 0.217 | 9.29 | 0.040 | 0.321 | 3.2.1.41 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.01 | 1lm1A | 0.286 | 9.81 | 0.052 | 0.435 | 0.88 | F3S | complex1.pdb.gz | 646,647,648,652,653,654,687,691,1052
| 2 | 0.01 | 3ob8C | 0.233 | 9.19 | 0.044 | 0.345 | 0.58 | MG | complex2.pdb.gz | 317,637,641
| 3 | 0.01 | 1llzA | 0.285 | 9.83 | 0.047 | 0.435 | 0.57 | F3S | complex3.pdb.gz | 323,603,604,605,606,637,638,639
| 4 | 0.01 | 3obaC | 0.203 | 9.87 | 0.027 | 0.315 | 0.57 | MN3 | complex4.pdb.gz | 746,747,1103,1104,1126
| 5 | 0.01 | 1jyxA | 0.235 | 8.74 | 0.040 | 0.337 | 0.66 | NA | complex5.pdb.gz | 367,384,385,387,388
| 6 | 0.01 | 1llwA | 0.284 | 9.71 | 0.056 | 0.431 | 0.60 | F3S | complex6.pdb.gz | 649,650,651,653,654,687,692
| 7 | 0.01 | 1ofdA | 0.288 | 9.76 | 0.056 | 0.436 | 0.51 | F3S | complex7.pdb.gz | 322,323,324,325,326,366,374,377
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.