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# D-I-TASSER results for P02461-D1

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>P02461 (1466 residues) MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSV LCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRN GDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPG PPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPG ERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMG PRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPG SNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAG ANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPG AAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPG SPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPG GPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPG PKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAG TPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKG EGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPG VAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPG KDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAG PPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDG LPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAG SRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRG PVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGV GAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPAR NCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSS AEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQNITYHCKNSIAYMD QASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLP IVDIAPYDIGGPDQEFGVDVGPVCFL

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 1400 1420 1440 1460
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Prediction
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCSCSCCCSSCCCCCCCCCCCSSSSS SCCCCCCCCCCCCCSSCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCHHHCCCCSCCCCCCCCSSSSSSSCCCSSSCCCCCCCCCCSSCCCCCHHHHCCCCCCCSSSSSSCCCCSCCCCCCCSSSSSSSCCCCCCCCCSSSSCCCCCCCCCSSSSSSCCCCCC
Confidence
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 1400 1420 1440 1460 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Prediction |
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 1400 1420 1440 1460 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCSCSCCCSSCCCCCCCCCCCSSSSS SCCCCCCCCCCCCCSSCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCHHHCCCCSCCCCCCCCSSSSSSSCCCSSSCCCCCCCCCCSSCCCCCHHHHCCCCCCCSSSSSSCCCCSCCCCCCCSSSSSSSCCCCCCCCCSSSSCCCCCCCCCSSSSSSCCCCCC
1 | 3hr2B | 0.39 | 0.25 | 7.31 | 1.53 | FFAS-3D |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKGVSAGP G PMGLMGPRGPGAVGA--G PQGFQGPA GEEGQTG PAGSRG PAG PGKAGEDGHGKPGRG E R GVVG PQGARGFGTGLG-------------FGIRGHNGLDG L K GQ-------G AQGVGEGAGENGTGQAGARGLGERGRVGAGPAGARGSDGSVG PVGPA GPIG SAGPGFGAG PGELGPVGNGPAGPAGPRGEAGLGLSG PVG PGNPGANGLTGAGATGLGVAG AGLGPRGIG PVGAA G ATGPRG LVGEGPAGSGETGNKGEGSAGAQG-------------------P GPSGEEGKRGSPG EPGSAGPAG PGLRGSGSRGLGADGRAGVMG PPGNR GSTGPAGVRGPNGDAGRGEGLMGPRGLG SGNVGPAGKEGPVGLGIDGRG PIG PAGPRGEAGNIGFGPKGPSGDGKG EKGHP GLAGARGAGPDGN--NGAQGP G PQGVQGGK GEQG PAG PGFQGLGPSGTAGEVGKGERGLP GEFGLGPAGPRGERPGESG AAGPSG PIG-------IRGPSGAG PDGNK GEA GAVGAP GSA GASGPGGLGE--RGAAGIGGK GEK G ETGLRGEIGNP GRD GAR GAGA--IGAG P A GASG DRG EAG AAGPSGPA G P R G S P G E R G EVG PAG PNG FAGPAGSAGQAGEK GTKGPKG ENGIVG PTGPVGAAGPS G PNG P P G PAGSRGDGGPP GMTG-------FGAAGRTGPGPSGITGPGPGAAG KEGIRG PRGDQGPVGRTGEIGASGPPGFAG E K GPSGEGTTGPGTA--------GPQG LLGAGILGLGSRGERGQ GIAGALGEGPLGI--AGPGARG PGAVGSGVNGA G EAG R D G NGSDGP----GRDGQGHKGERGYGNIGPTG AAGAP G PHGSV G P A G KHGNR G EPG P A GSVGPVGAVGPR GPSG P Q GIR G D K G EPGD----GARGLPGLKGHNGLQGLP GLA GLHGDQGAP G PVG PAG PRG PAG PSGPIGKDGRSGHPG PVG PAGVR GSQG SQGPAGPGPGP G P P GVSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 | 3gavA | 0.11 | 0.09 | 3.06 | 2.23 | SPARKS-K |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDCNELP PRRNTEILTGSWSDQTYPEG YKCRP GSLGNVIRKGEWVALNP----LRKCQKRPCGHP GDTPFGTFTLTGGNVFEYGVKAYTCNEGYQ-LLGEINDTDGWTNDIPICEVVKCLPVTA PENGKIVSSAMEPDREYHFGQAVREGDEEMHSDD GFWSKEKPKCVEISCKS PDINGSPISQKIIYKENEMGYEYSERGDAVCTESGWRPLPSCEEKSCD-----NPYI PN--GDYSPLRIKHRTGDEITYQCRNGFYPATRGNTGWIPAP RCTLKPCDYPDIKH--------GGLYHENMRRPYFPVAVGKYYSYYCD---EHFETPS---GSYWDHIHCTQDGWSPAVP------CLRKCYFPYLENGYNQNHGRKFVQGK-------------------SIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTDIPVFMNATKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEPGFTIV-G PNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLM----K GPNKIQCVDG EWTTLPVCIVEESTCGDIPELEHGAQLSSPPYYYGDSVEFNCSESFTMIGHRIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHN---SNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYR-DGEKVSVLCQENY-LIQEGEEITCKD GRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSESYAHGTKLSYTCEGGFRISEENETTSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFEGEKKDVYKAGYYKMDGASNVTCINSRWTGRPTCRDTSCVNP PTVQN----------------------AYIVSRQMSKYP------------SGERVRYQCRSPYEMFGEEVMCLNGN--------------WTEPPQC--------KDSTGKC---GPPPPIDNGDITSFPLSVY--------------------------------------APASSVEYQCQN------------------------LYQLE G NKRITCRKCLHPCVISREIMENYNIALRWKQKLYSRTGESVEFVSSSHTLRTGKLEYPTCAK
3 | 3hqvA | 0.57 | 0.39 | 11.30 | 9.31 | CNFpred |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG PMG PSG PRGLMGPMGAMGPQGFQ G PMG EMGEMGGS G PMG P P GPMG PMGKNGDD G EAGKP G RMG E R GPMG PQGARGLMGTAGLMG MMG H R G FSGLDGAK GDT GPAGPK G EMGSMG E N GTMGQM G P R GLMG E R G RMGPMGTA G A R G N D G AVGAAGPMG PTG PTGPMG FMGAAG A K G EAG PQGARG SEGPQGVR G EMG PMGPA G AAG PAGNMGADGQMGAK GANGAMG IAG AMGFM G A R G PSG PQGPSG AMGPKGTSG EMGAMGNK GDTGAKG EMGPA GVQGPMGPAG EEG KRGARG EMGPSG LMGPMG E R GGMGSR GFMGADGVAGPK G PSG E R GSMG P A G PKGSMG EAG RMGEAGLMGAKGLTG SMGSMGPD G KTG PMGPAGQDG RMG PAG PMGAR G QAG V M G FMG P K GTAGEMG KAG E R GVMGPMGAVG PAG KDG EAGAQ GAMG PAG PAGERGEQG PAGSMGFQ G LMGPAG PMG EAG KMG EQGVMG DLG AMGPSGARGERGFMG E R GVQGPMGPAGPR GNNGAMGNDGAK GDTGAMGAMGSQGAMG L Q G MMG E R GAAGLMG P K G DRGDAGPKG A D GSP G K D GVR GLT G P I G PMG P A GAMG D K G EAGPSGPAGPTGAR GAMGDR G EAG PMG P A G FAGPMGADGQMGAK G EMGDTGVK GDAG PMGPA G PAGPMG PIGNVGAMGPMGSR GAAGPMG ATG FMG AAGRVG PMGPSG NAG PMG PMGPVG KEGGKG PRGET GPAGRMGEVG PMGPMGPAG E K G SMG ADG PAGSMGTPGPQG IAGQR GVVGLMGQRGKR GFMGLMGPSG EMG KQGPSGAS G E R G PMG PMGPMG L A GPMG ESG REGSMGAEGSMG R D GAMGAK G D R G ETGPAGPMG AMGAMGAP G P V G P A G KNG D R G ETG P A G P A GPIG P A GAR GPAG P Q G P R G DMG E T G EQGDRG IMG H R G FSGLQGPMG SMGSMGEQ GPSGASG P A G P R G PMGSAGSMG K D GLNGLMG P I GMMG P R GRTGDSGPAGPMGPMGPMG PMG P PSGGY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 | 3hr2B | 0.55 | 0.35 | 10.11 | 3.29 | MUSTER |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKGVSAGPG PMGLMG PRGP-GAVG-AGPQGFQ G PAG EEG QTG PAGSRG PAG----PGKA GED GH-GKP G R-G E R GVVG PQGARGFGTGLG----FGIR GHNGLDGLK GQGA----QGVGEGAG E N G-TGQAGAR G-LG E R G RVG-AGPA G A R GSD GSVGPVGPAG PIGSAG----P GFGAGPG ELG PVG-NGPAGPAGPR G EAGL-GLSGPVG-P GNP GAN GLTG-AGATGL-GVAG A--GLGPR G-IG PVG AAG ATGPR GLVG E-GPAGS-G ETGNKG E-GSA GAQG-P GPSG EEG KRG S P G E P GSAGPAG-PGLR G-SGSR GL-GADGRAGVMG PPGNR GSTG P A GVR GPNGDAG RG--EGLMGPR GLG--SGNVGPAG KEG PVG-LGIDG-RG PIG PAG P R GEAGNIG F-G P K GPSGD--GKG EKGHP GLAGARG-AGPDGNNGAQ G-P G PQGVQGGK GEQG PAG P-GFQ G L-GPSGTAG EVG K-G ERGLPGEFG-LGPAGPRGERG-P G ESGAAGPSGPIGIR GPSG-AG PDGNK GEA GAVGAP GSA GASGPGGL-G E R GAAG-IGGK GEK G ETGLRGEIGNP GRD GAR GA-GAI G-AG P A GASG DRG EAG AAGPSGPA G P R G S P G E R G EVG PAG PNG FAGPAGSAGQG--AG EKGTKGPK G ENGIVGPTG PVGAAG PSG PNG PPGPAGSR GDGGPP GMTG F-G AAGRTG P-GPSGITG PG--PGAAG KEGIRG PRGDQGPVGRTGEIGASGPPGFAG E K GPSGEGTTP GTAG PQGLLG----AGILG-LGSRGER G-QGIAGALG E-GPLGIAG-PGAR G-P GAVG-SGVNG-A G EAG R D G-NG S D G-P G R D GQ-GHK GER GY-GNIGPTG AAGAP G PHGSV G P A G KHGNR G EPG P A GSVGPVGAVGPR GPSG P Q GIR G D K G EPGD-G ARGLPGLKGHNGLQGLP GLAGLHGDQ G APGPVG P A G P R G PAG P S G PIG K D GRS G H P G PVG PAGVR GSQGSQGPAGPGPGP GPP GVSG-GG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 | 3hr2B | 0.54 | 0.35 | 10.03 | 5.51 | HHsearch |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------SDKGVS------AGPG PMGLMG PRGP-GAVG-AGPQGFQ G PAG EGG QTG PAGSRG PA---G-PGKA GED GH----GKP GR-GERGVVGPQGARGFGTGLG-FGIR GHNGLDGLK GQGA----QGVGEGAG E N G-TGQAGAR GL-G E R G RVGA-GPA G A R GSD GSVGPVGPAG PIGSAGP-G FGA---GPG ELG PVGN-GPAGPAGPR G EAGL-GLSGPVG-P GNP GAN GLTGA-GATGL-GVAG A--GLGPR GI-G PVG AAG ATGPR GLVG E-GPAGS-G ETGNKG E-GSA GAQG-P GPSG EEG KRG S P G E P GSAGPAGP-GLR G-SGSR GL-GADGRAGVMG PPGNR GSTG P A GVR GPNGDAG RG--EGLMGPR GLG--SGNVGPAG KEG PVGL-GIDG R-G PIG PAG P R GEAGNIG F-G P K GPSGD--GKG EKGHP GLAGARGA-GPDGNNGAQ G P-G PQGVQGGK GEQG PAG-PGFQ G L-GPSGTAG EVG K-G ERGLPGEFGL-GPAGPRGERG-P G ESGAAGPSGPIGIR GPSGA-G PDGNK GEA GAVGAP GSA GASGPGGL-G E R GAAGI-GGK GEK G ETGLRGEIGNP GRD GAR GA-GAI GA-G P A GASG DRG EAG AAGPSGPA G P R G S P G E R G EVG PAG PNG FAGPAGSAGQG--AG EKGTKGPK G ENGIVGPTG PVGAAG PSG PNG PPGPAGSR GDGGPP GMTG F-G AAGRTG P-GPSGITG P--GPGAAG KEGIRG PRGDQGPVGRTGEIGASGPPGFAG E K GPSGEGT-TG-P GTAGPQGLLG A-GILGL-GSRGER GQ-GIAGALG E----GPLGIAGAR G-P GAVG-SGVNG-A G EAG R D G N-G S D G-P G R D GQ-GHK GER GNIGPTG---AAGAP G PHGSV G P A G KHGNR G EPG P A GSVGPVGAVGPR GPSG P Q GIR G D K G EPGD-G ARGLPGLKGHNGLQGLP GLAGLHGDQ G APGPVG P A G P R G PAG P S G PIG K D GRS G H P G PVG PAGVR GSQGSQGPAGPGPGP GPP GVSGGG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 | 3hr2A | 0.28 | 0.17 | 5.35 | 1.50 | FFAS-3D |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPQGFQG PGEGEGGSGPMG PPG PGPKNGDDGEAGKP GRGE--RGP GPQGARGLGTAGLGMG H R G FSGLDGAK GDT GPAGPK G EGSGENGTGQMG PRGLGERGRGPGTAGARGNDG AVGAAGPGPTGPTGPGFGAAGAKGEAGPQG ARGSEG PQGVRGEPGPAGAAGPAGNGADGQGAKGANGAG IAGAGFGARGPSGPQGPSGAGPKGTSGEGAGNKGDTGAKGEGPA GVQGP-GPAG EEGKR GAR G EGPSGLGP GERGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSG PDGKTGPGPAGQDGRGGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVG PAGKDGEAGAQG-AGPAG PAGERGEQGPAGSGFQGLG PAGPGEAG KGEQGVGDLGAG PSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGE--RGAAGLG PKGDRGDAGPKGADGSP GKDGVRGLTG PIG PGP--AGAGDKGEAGPSGPAGPTGARGAGDRGEAP GPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKG PRGETG PAGRGEVGPGP G PAGEK GSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGLGPSGEGKQG PSGASGERGPGPMGPGLAGPGESGREG SGAEGSGRDGAGAKGDRGET GPAGPGAGAGAP G PVGPAGKNGDRG ETGPAGPAGPIGPAGARG PAGPQGPRGDGETGEQDRGIGHRGFSGLQGPGSGSGEQGPSGASGPAGPRGPGAGSGKDGLNGLGPIGGPRGRTGDSGPAG PGPGPGPGPPSGGYDFSFLPQPPQEKSQDGGRYY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7 | 3gawA | 0.12 | 0.09 | 3.23 | 2.23 | SPARKS-K |  | -------------------------------------------------------------------------------------EDCNELPP----RRNTEILTGSWSDQTYPEGTRSLGNVIMVCRKGEWVALNPLRKCQPCGHPGD---TPFGTFTLTNVFEYGVKAVYTCN------------EGYQLLGEINYRECDTD-----GWTNDIPICEVV-----KCLPVTAPENGKIVSSAMEPDREYHFGQAVSGYK-IEGDEEMHCS--DDGFWSKEKPKCVEISCKS--------PDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTEGWRPLPSCEEKSCDNPYI-PN GDYSPLRIKHRTGDEGFYPATRGNTAKCTSTGWI--------PA PRCTLKPCDY--------PDIKHGGLYHENMRRPYFPVAVGK--YYSYYCDEHFETPSGSYWDHIHCTQDG--WSPAVPCLRKCYFPYLEN GYNQNHGRKFVQGKS-----IDVACHP GYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDI-PVFMNARTKNDFTWFKLNDTLDYEC--------------HDGYESNTGSTTGS---------IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKF--------------SCKPGFT-------IVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNV----KEKTKEEYGHSEV-VEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEES-----TCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSN-LIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGWDPEVNCAQIQLCPPPPQIPNSHNMTTTLNYRG EKVSQENYLIQEGEEITCKDG RWQSIPVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKTCEGGFRISEENEYMGKSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYG EE--VTYKCFEG FGGPAILGEKWSHPPSCIKTDCLSLPSFENPMGEKKDVYKAGEQVTATYYKMDGASNVTCINSRWTGRPTCRDTSCVNP PTVQN--------------AYIVSRQMSKYPSGERVRYQCR--------SPYEMFGDEEVMLNGNWTEPPQCKDSTGKCGPPIDNGDIVYAPASSVEYQCQNLYQLEGNKRT CRNGQWSEPPKLHPCVISREENYNIALRWTAKQKLYSRTGE------------------------SVEFVC K-----------------------RGYRLSSRSHTLRTTCWD-------GKLEYPTCAKR----------------------------------
8 | 3hqvB | 0.52 | 0.36 | 10.51 | 8.90 | CNFpred |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG PMGLMG PRGPMGAVGAMGPQGFQ G PAG EMGEMGQTG PAGSRGPAG PMGKA GED GHMGKP G RMG E R GVVG PQGARGFMGTMGLMGFMGIR GHNGLDGLK GQMG AQGVMG EMGAMG E N GTMGQAGAR GLMG E R G RVGAMGPA G A R GSD GSVGPVGPAG PIGSAGPMG FMGAMGPMG ELG PVGNMGPAGPAGPR G EAGLMGLSGPVG PMGNP GAN GLTGAMGATGLMGVAG AMG L M GPR GIMG PVG AAG ATGPR GLVG EMGPAGSMG ETGNKG EMGSA GAQGPMGPSG EEG KRG S P G E P GSAGPAGPMGLR GSMGSR GLMGADGRAGVMG PPGNR GSTG P A GVR GPNGDAG RMGEMGLMGPR GLMG SMGNVGPAG KEG PVGLMGIDG RMG PIG PAG P R GEAGNIG FMG P K GPSGDMG KMG EKGHP GLAGARGAMGPDGNNGAQ G PMG PQGVQGGK GEQG PAG PMGFQ G LMGPSGTAG EVG KMG ERGLPGEFGLMGPAGPRGERGPMG ESGAAGPSGPIGIR GPSGAMG PDGNK GEA GAVGAP GSA GASGPGGLMG E R GAAGIMGGK GEK G ETGLRGEIGNP GRD GAR GAMGAI GAMG P A GASG DRG EAG AAGPSGPA G P R G S P G E R G EVG PAG PNG FAGPAGSAGQMGAMG EKGTKGPK G ENGIVGPTG PVGAAG PSG PNG PPGPAGSR GDGGPP GMTG FMG AAGRTG PMGPSGITG PMG PMGAAG KEGIRG PRGDQGPVGRTGEIGASGPPGFAG E K GPSGEMGTTGPMGTAGPQGLLG AMGILGLMGSRGER GQMGIAGALG EMGPLGIAGPMGAR G PMGAVGSMGVNGAMG EAG R D G NMG S D GPMG R D GQMGHK GER GYMGNIGPTG AAGAP G PHGSV G P A G KHGNR G EPG P A GSVGPVGAVGPR GPSG P Q GIR G D K G EPGDMG ARGLPGLKGHNGLQGLP GLAGLHGDQ G APGPVG P A G P R G PAG P S G PIG K D GRS G H P G PVG PAGVR GSQGSQGPAGPMGPMGPMG P P GVSGGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9 | 3hr2A | 0.58 | 0.37 | 10.70 | 2.94 | MUSTER |  | -----------------------------------------------------------------------------------------------------------------------------------------------------QMSYGY DEKSAGV--------------SVP G PMG PSGPRGLGPGAGPQGFQ G PGEGEGGSG PMG P P G PG-----PGKNGDD G EAGKP G R-G E R G-P G PQGARGL-GTAG-LG-MG H R G FSGLDGAK GDT GPAGPK G EG--SG E N G-TGQM G P R G-LG E R G RG--P GTA G A R G N D G AVGAAG-P G PTG PTG-PG F-GAAG A K G EAG PQGARG SEGPQGVR G EG--PGPA G AAG PAG-NGADG-QGAK GANGA-G IAG AG---G A R G PSG PQGPSG-AGPKGTSG EG--AGNK GDTGAKG E-GPA GVQG-P GPAG EEG KRGARG EGPSGLGP GERGG-GSRG F----GADGVAGPK G PSG E R G-SG P A G PKGS-G EAG R-GEAG-LGAKGLTG SG--SGPD G KTG-P GPAGQDG-RG PAG P-GAR G QAG V M G F-G P K GTAG-EG KAG E R GVG--P GAVG PAG KDG EAGAQ G-AG PAG PAGERGEQG PAGS-GFQ G-LGPAG-P G EAG K-G EQGV-G DLG-AGPSGARGERG-FG E R GVQG-PGPAGPR GNNG-AGNDGAK GDTGAG--AGSQG-AG L Q G M-G E R GAAG-LG P K G DRGDAGPKG A D GSP G K D GVR GLT G P I G-P G P A G-AG D K G EAGPSGPAGPTGAR GA-GDR G EAG-P G P A G FAG-P GADGQ-GAK G E-GDTGVK GDAG-P GPA G PAG-PG PIGNVG-AG-PGSR GAAG-P G ATG F-G AAGRVG-P GPSG NAG PG--PGPVG KEGGKG PRGET GPAGRGE-VG P--GPGPAG E K G S-G ADG PAG-SGTPGPQG IAGQR GVVG-LGQRGKR GFLG PSG----EG KQGPSGAS G E R G-P G PMG-P G L A G-PG ESG REGSG-AEG-SG R D G-AGAK G D R G E---TGPAGPGAGAGAP G P V G P A G KNG D R G ETG P A G P A GPIG P A GAR GPAG P Q G P R G D-G E T G EQGDRG I----GHRGFSGLQGPGSGSGEQ GPSGASG P A G P R G P--GSAGSG K D GLNG-LG P I G--G P R GRTGDSGPAGPGPGP-GP G P PSGGYDFSF---------LPQPPQE KSQDGGRY Y------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 | 3hr2A | 0.59 | 0.38 | 10.86 | 5.35 | HHsearch |  | -----------------------------------------------------------------------------------------------------------------------------------------------------QMSYG---Y DEK S-----AGVSVP G PMG P---SG PRG---LGPGAGPQGFQ G PGEGEGGSG PMG P P G PG-----PGKNGDD G EAGKP G R-G E R G-P G PQGARGL-GTAGL-G-MG H R G FSGLDGAK GDT GPAGPK G EG--SG E N G-TGQM G P R GL-G E R G RG--P GTA G A R G N D G AVGAAGP-G PTG PTG-PG F-GAAG A K G EAG PQGARG SEGPQGVR G EG--PGPA G AAG PAGN-GADG-QGAK GANGA-G IAG A--GFG A R G PSG PQGPSG A-GPKGTSG EG--AGNK GDTGAKG E-GPA GVQG-P GPAG EEG KRGARG EGPS-G--LGPG E R GG-GSR GF-GADGVAGPK G PSG E R G-SG P A G PKGS-G EAG R-GEAGL-GAKGLTG SG--SGPD G KTG P-GPAGQDG R-G PAG-PGAR G QAG V M G F-G P K GTAGE-G KAG E R GV--G P GAVG PAG KDG EAGAQ G-AG PAG PAGERGEQG PAG-SGFQ G L-GPAG-P G EAG K-G EQGV-G DLG A-GPSGARGERGF-G E R GVQGP-GPAGPR GNNGA-GNDGAK GDTGA--GAGSQG-AG L Q G M-G E R GAAGL-G P K G DRGDAGPKG A D GSP G K D GVR GLT G P I G P-G P A GA-G D K G EAGPSGPAGPTGAR GA-GDR G EAG P-G P A G FAGP-GADGQ-GAK G E-GDTGVK GDAG-P GPA G PAG-PG PIGNVGA-G-PGSR GAAG-P G ATG F-G AAGRVG P-GPSG NAG PG--PGPVG KEGGKG PRGET GPAGRG-EVG P--GPGPAG E K G S-G ADG PAGS-GTPGPQG IAGQR GVVGL-GQRGKR GF-GL-GPSG E-G KQGPSGAS G E R G P-G PMGP-G L A GP-G ESG REGSG-AEG-SG R D GA-GAK G D R G ETGPAGPGAG---AGAP G P V G P A G KNG D R G ETG P A G P A GPIG P A GAR GPAG P Q G P R G D-G E T G EQGDRG I-G H R G FSGLQGPG---SGSGEQ GPSGASG P A G P R G PG-SA-GSG K D GLNGL-G P I G--G P R GRTGDSGPAGPGPGP----GP G P PS---GGY---DFSFLPQPPQE KSQDGGRY Y------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.1991
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 1ulvA | 0.12 | 8.32 | 0.035 | 0.158 | model1_1ulvA.pdb.gz
| 2 | 1ivsA | 0.11 | 8.39 | 0.034 | 0.153 | model1_1ivsA.pdb.gz
| 3 | 1it7A | 0.11 | 7.32 | 0.053 | 0.140 | model1_1it7A.pdb.gz
| 4 | 1ffyA | 0.11 | 8.98 | 0.021 | 0.154 | model1_1ffyA.pdb.gz
| 5 | 1jzsA | 0.10 | 8.22 | 0.049 | 0.141 | model1_1jzsA.pdb.gz
| 6 | 1tg7A | 0.10 | 8.50 | 0.051 | 0.137 | model1_1tg7A.pdb.gz
| 7 | 1xfuA | 0.10 | 8.19 | 0.068 | 0.136 | model1_1xfuA.pdb.gz
| 8 | 1kekA | 0.10 | 8.94 | 0.031 | 0.141 | model1_1kekA.pdb.gz
| 9 | 1ej6A | 0.10 | 9.74 | 0.051 | 0.147 | model1_1ej6A.pdb.gz
| 10 | 1u1uA | 0.10 | 7.96 | 0.054 | 0.132 | model1_1u1uA.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0005198 | 0.61 | structural molecule activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0044699 | 0.93 | single-organism process
GO:0009987 | 0.75 | cellular process
GO:0032502 | 0.73 | developmental process
GO:0044763 | 0.68 | single-organism cellular process
GO:0048856 | 0.65 | anatomical structure development
GO:0044767 | 0.65 | single-organism developmental process
GO:0016043 | 0.61 | cellular component organization
GO:0065007 | 0.56 | biological regulation
GO:0030198 | 0.54 | extracellular matrix organization
GO:0050789 | 0.52 | regulation of biological process

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 0.72 | cell part
GO:0044421 | 0.69 | extracellular region part
GO:0032991 | 0.65 | macromolecular complex
GO:0043234 | 0.64 | protein complex
GO:0044424 | 0.62 | intracellular part
GO:0005581 | 0.59 | collagen trimer

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 1sk6C | 0.077 | 7.90 | 0.042 | 0.104 | 4.6.1.1 | NA
| 2 | 0.060 | 1mxgA | 0.091 | 6.75 | 0.033 | 0.115 | 3.2.1.1 | NA
| 3 | 0.060 | 2tmdA | 0.086 | 8.02 | 0.040 | 0.117 | 1.5.8.2 | 77
| 4 | 0.060 | 1ffyA | 0.107 | 8.98 | 0.021 | 0.154 | 6.1.1.5 | NA
| 5 | 0.060 | 2b4kA | 0.076 | 8.05 | 0.047 | 0.103 | 3.1.1.43 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.01 | 1k903 | 0.086 | 6.88 | 0.022 | 0.109 | 0.13 | III | complex1.pdb.gz | 1211,1212,1323,1327,1328,1345,1346,1347,1360,1361
| 2 | 0.01 | 1xfvA | 0.098 | 8.25 | 0.057 | 0.135 | 0.10 | 3AT | complex2.pdb.gz | 264,265,267,274
| 3 | 0.01 | 1jzsA | 0.103 | 8.22 | 0.049 | 0.141 | 0.12 | MRC | complex3.pdb.gz | 103,104,112,114,115
| 4 | 0.01 | 1k930 | 0.088 | 6.65 | 0.053 | 0.110 | 0.12 | III | complex4.pdb.gz | 1214,1349,1392
| 5 | 0.01 | 1gaxA | 0.111 | 8.38 | 0.031 | 0.152 | 0.13 | VAA | complex5.pdb.gz | 49,106,108,109,110,111,114
| 6 | 0.01 | 1ffyA | 0.107 | 8.98 | 0.021 | 0.154 | 0.11 | MRC | complex6.pdb.gz | 101,102,117,118,119
| 7 | 0.01 | 1sk6B | 0.090 | 6.86 | 0.032 | 0.115 | 0.22 | CMP | complex7.pdb.gz | 462,463,474,475,476
| 8 | 0.01 | 1sk6A | 0.075 | 8.48 | 0.076 | 0.106 | 0.23 | CMP | complex8.pdb.gz | 468,469,473
| 9 | 0.01 | 1xfwA | 0.097 | 8.26 | 0.064 | 0.135 | 0.31 | CMP | complex9.pdb.gz | 444,445,446,447,448,450
| 10 | 0.01 | 1sk6C | 0.077 | 7.90 | 0.042 | 0.104 | 0.27 | CMP | complex10.pdb.gz | 129,130,131,133,135,136
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.