GO:0003824	F	0.97	catalytic activity
GO:0016491	F	0.95	oxidoreductase activity
GO:0016903	F	0.69	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0004738	F	0.48	pyruvate dehydrogenase activity
GO:0016624	F	0.45	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0003826	F	0.38	alpha-ketoacid dehydrogenase activity
GO:0004739	F	0.32	pyruvate dehydrogenase (acetyl-transferring) activity
GO:1901363	F	0.28	heterocyclic compound binding
GO:0097159	F	0.28	organic cyclic compound binding
GO:0036094	F	0.20	small molecule binding
GO:0000166	F	0.17	nucleotide binding
GO:0035639	F	0.15	purine ribonucleoside triphosphate binding
GO:0032555	F	0.15	purine ribonucleotide binding
GO:0032550	F	0.15	purine ribonucleoside binding
GO:0016620	F	0.14	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0043167	F	0.13	ion binding
GO:0030554	F	0.13	adenyl nucleotide binding
GO:0016829	F	0.12	lyase activity
GO:0005524	F	0.12	ATP binding
GO:0003863	F	0.12	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
GO:0046872	F	0.11	metal ion binding
GO:0044877	F	0.11	macromolecular complex binding
