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# D-I-TASSER results for P42262-D2

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>P42262 (271 residues) LPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI SIMIKKPQVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS LRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260
| | | | | | | | | | | | |
LPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE
Prediction
CCCCCCCCCCCCCSSSSSSCCCCCCSSSCCCCCCCCCCCCSSSSS HHHHHHHHHHHCCSSSSSSCCCCCCCCCCCCCCCCHHHHHHHHHCCCCSSSSCCSCCHHHHHCSSSCCHHHCCCSSSSSSCCCCCCCCCHHHCCCCSSSSSSSSCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCSSSCCHHHHHHHHHHCCCCSSSSSCHHHHHHHHHHCCCCSSSSCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
Confidence 9999875112698899996578996243377543178996898719999999999699499998678755554667876314789998568888986361488897311115124305749999879887877877739937999997443359986412243034668887633687336346289999999489868999368999999981999689927778874259999389789999999999999808799999965356899
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 | | | | | | | | | | | | | LPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE
Prediction | 4345455651562101000243311212344552356743010000100420074161514033164453444446434031003304534020000001025404411210323142100000215473434334234431002202311110242246442522542252146443312243334003203654200000002101300363574412202561566300000314460152035025403741415303723357578
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 | | | | | | | | | | | | |
| SS Seq | CCCCCCCCCCCCCSSSSSSCCCCCCSSSCCCCCCCCCCCCSSSSS HHHHHHHHHHHCCSSSSSSCCCCCCCCCCCCCCCCHHHHHHHHHCCCCSSSSCCSCCHHHHHCSSSCCHHHCCCSSSSSSCCCCCCCCCHHHCCCCSSSSSSSSCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCSSSCCHHHHHHHHHHCCCCSSSSSCHHHHHHHHHHCCCCSSSSCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC LPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE
1 | 5dt6A | 0.53 | 0.51 | 14.81 | 1.50 | DEthreader |  | ----GS--YDRNHTYIVSSLL EEP YLSLKQYTESLVG NDRFE G Y CKD L ADMLAAQLGIK YEIRLVQD GNY G AENQYAPGWDG M V G E LIRKEA D I A ISAMT I TAER ERV I D F S K P F MTL G I S I M I K KG-TPIKT-PE D LTMQ TDVNY G T LLYG S TWE F F R R SQIGLHNK M WEY MNA-NQHHSVHTYDE GIRR V RQS K G K Y ALLVEPKNEYVNAR-PP C D T M K V GRNIDTK GFGVA T PIG SPL RKRLNEA V LTLKENGELLRIRN K W WFD KTE
2 | 5dt6A | 0.56 | 0.54 | 15.61 | 1.81 | SPARKS-K |  | ------GSYDRNHTYIVSSLL EEP YLSLKQYTESLVG NDRFE G Y CKD L ADMLAAQLGIK YEIRLVQD GNY G AENQYAPGWDG M V G E LIRKEA D I A ISAMT I TAER ERV I D F S K P F MTL G I S I M I K KG--TP IKTPE D LTMQ TDVNY G T LLYG S TWE F F R R SQIGLHNK M WEY MNAN-QHHSVHTYDE GIRR V RQS K G K Y ALLVE SPKN E YVNARPP C D T M K V GRNIDTK GFGVA T PIG SPL RKRLNEA V LTLKENGELLRIRN K W WFD KTE
3 | 5dtbA | 0.55 | 0.52 | 14.89 | 0.61 | MapAlign |  | ----------KN K TLV V T T I LSNP YCMRKESAIPLSG NDQFE G YAV D LIHE ISKSLG FNY KIQLVPD GSY GSLNKLTGEW N G MIRE LLEQRA DLA I ADL T I TFER EQAVD FTTP F MNL GVS ILYRK--GTP I E S A E D LAK Q TRIKY GALKGG S TAAF F RDS K ISTYQRM WSFMES ARP S V FTASNGE G VER VAKGK GSY AFLME S TSIE YVTE-RNCELTQV G GML DTKSY G I A T PPNSPYRTAINSVIL K LQEEGKLHIL KTK W WKEK--
4 | 5dtbA | 0.54 | 0.52 | 14.90 | 0.49 | CEthreader |  | ----------KN K TLV V T T I LSNP YCMRKESAIPLSG NDQFE G YAV D LIHE ISKSLG FNY KIQLVPD GSY GSLNKLTGEW N G MIRE LLEQRA DLA I ADL T I TFER EQAVD FTTP F MNL GVS ILYRKGT--P I E S A E D LAK Q TRIKY GALKGG S TAAF F RDS K ISTYQRM WSFMES ARP S V FTASNGE G VER VAKGK GSY AFLME S TSIE YVTE-RNCELTQV G GML DTKSY G I A T PPNSPYRTAINSVIL K LQEEGKLHIL KTK W WKEKRG
5 | 5dtbA | 0.54 | 0.51 | 14.80 | 1.48 | MUSTER |  | ----------KN K TLV V T T I LSNP YCMRKESAIPLSG NDQFE G YAV D LIHE ISKSLG FNY KIQLVPD GSY GSLNKLTGEW N G MIRE LLEQRA DLA I ADL T I TFER EQAVD FTTP F MNL GVS ILYRKGTP--I E S A E D LAK Q TRIKY GALKGG S TAAF F RDS K ISTYQRM WSFMES ARP S V FTASNGE G VER VAKGK GSY AFLME S TSIE YVTERNC-ELTQV G GML DTKSY G I A T PPNSPYRTAINSVIL K LQEEGKLHIL KTK W WKEKRG
6 | 5l2eA | 0.34 | 0.32 | 9.51 | 1.31 | HHsearch |  | NPVTGLN-GSLGVVLRVVTVL EEPFV MVSENV--LGKPKKYQGFSIDVLDALSNYLG FNYEIYVAPDHK Y GSPQE-DGTW N GLV G E L VFKRA D IGISAL T I TPDR ENVVD FTTRYMDYSVGVLLRR----SIQSLQD L S K Q TDIPY G TVLDSAVYQHVRMKGLSMYSQM WRMIN-----NNVLESQAGIQKVKYGN--Y AFVWDAAVLE YVAIDPDCSFYTV GNTVADRG Y G I ALQHG SPYRDVFSQRILELQQSGDMDIL KHK W WPKNGQ
7 | 1yaeA | 0.49 | 0.47 | 13.61 | 2.61 | FFAS-3D |  | -PAN-ITDSLSNRSLIV T T I L EEP Y VLFK KSDKPLYG NDRFE G Y CID LLRELSTILG FTYEIRLVED G K Y G AQDDVNGQW N G M VRE LIDHK A DLAVA P LAI TYV R EKV I D F S K P F MTL G I S ILYRKIDS-----ADD LAK Q TKIEY GAVEDGATMTF FKKS K ISTYD K M WAFMSSRRQS VLVKSNEE GIQR VLTSD---YAFLMESTTIEFVTQRNCNLTQIG GLID S K G Y GVGT PMG SPYRDKITIAILQLQEEGKLHMMKEK W WRGNG-
8 | 5dt6A | 0.55 | 0.53 | 15.21 | 0.95 | EigenThreader |  | ------GSYDRNHTYIVSSLL EEP YLSLKQYTYGESLVDRFE G Y CKD L ADMLAAQLGIK YEIRLVQD GNY G AENQYAPGWDG M V G E LIRKEA D I A ISAMT I TAER ERV I D F S K P F MTL G I S I M I K K--GTP IKTPE D LTMQ TDVNY G T LLYG S TWE F F R R SQIGLHNK M WEY MNAN-QHHSVHTYDE GIRR V RQS K G K Y ALLVE SPKN E YVNARPP C D T M K V GRNIDTK GFGVA T PIG SPL RKRLNEA V LTLKENGELLRIRN K W WFD KTE
9 | 5ybfA | 0.99 | 0.94 | 26.46 | 2.85 | CNFpred |  | -----------N K T V V V T T I L E S P Y V M M K K N H E M L E G N E R Y E G Y C V D L A A E I A K H C G F K Y K L T I V G D G K Y G A R D A D T K I W N G M V G E L V Y G K A D I A I A P L T I T L V R E E V I D F S K P F M S L G I S I M I K KG--TP I E S A E D L S K Q T E I A Y G T L D S G S T K E F F R R S K I A V F D K M W T Y M R S A E P S V F V R T T A E G V A R V R K S K G K Y A Y L L E S T M N E Y I E Q R K P C D T M K V G G N L D S K G Y G I A T P K G S S L R N A V N L A V L K L N E Q G L L D K L K N K W W Y D K G E
10 | 5dtbA | 0.52 | 0.49 | 14.20 | 1.50 | DEthreader |  | ----------KN K TLV V T T I LSNP YCMRKESAIPLSG NDQFE G YAV D LIHE ISKSLG FNY KIQLVPD GSY GSLNKLTGEW N G MIRE LLEQRA DLA I ADL T I TFER EQAVD FTTP F MNL GVS ILYRKG-TPIES-A E D LAK Q TRIKY GALKGG S TAAF F RDS K ISTYQRM WSFMES ARP S V FTASNGE G VER VAKGK GSY AFLMETSIEYVTER-N-CELTQV G GML DTKSY G I A T PPNSPYRTAINSVIL K LQEEGKLHIL KTK W WKEGGK
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.8801
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 5dt6A | 0.94 | 1.19 | 0.557 | 0.967 | model1_5dt6A.pdb.gz
| 2 | 5dtbA | 0.94 | 0.85 | 0.550 | 0.952 | model1_5dtbA.pdb.gz
| 3 | 4wxjA | 0.90 | 1.21 | 0.397 | 0.930 | model1_4wxjA.pdb.gz
| 4 | 4uqqA | 0.90 | 1.76 | 0.511 | 0.945 | model1_4uqqA.pdb.gz
| 5 | 5ikbA | 0.90 | 0.96 | 0.566 | 0.919 | model1_5ikbA.pdb.gz
| 6 | 1yaeA | 0.90 | 1.91 | 0.521 | 0.959 | model1_1yaeA.pdb.gz
| 7 | 4pe5A | 0.86 | 2.19 | 0.298 | 0.934 | model1_4pe5A.pdb.gz
| 8 | 1y20A | 0.85 | 1.90 | 0.319 | 0.915 | model1_1y20A.pdb.gz
| 9 | 4ykiA | 0.85 | 1.81 | 0.239 | 0.911 | model1_4ykiA.pdb.gz
| 10 | 4zdmA | 0.85 | 1.78 | 0.227 | 0.911 | model1_4zdmA.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0005230 | 1.00 | extracellular ligand-gated ion channel activity
GO:0004970 | 0.99 | ionotropic glutamate receptor activity
GO:0004971 | 0.95 | AMPA glutamate receptor activity
GO:0005234 | 0.90 | extracellular-glutamate-gated ion channel activity
GO:0030165 | 0.86 | PDZ domain binding
GO:0015277 | 0.83 | kainate selective glutamate receptor activity
GO:0042802 | 0.81 | identical protein binding
GO:0019899 | 0.81 | enzyme binding
GO:0019901 | 0.80 | protein kinase binding
GO:0005246 | 0.80 | calcium channel regulator activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0050794 | 0.97 | regulation of cellular process
GO:0044763 | 0.97 | single-organism cellular process
GO:0007215 | 0.94 | glutamate receptor signaling pathway
GO:0006810 | 0.94 | transport
GO:0050896 | 0.93 | response to stimulus
GO:0035235 | 0.93 | ionotropic glutamate receptor signaling pathway
GO:0060992 | 0.92 | response to fungicide
GO:0023051 | 0.92 | regulation of signaling
GO:0006811 | 0.92 | ion transport
GO:0034220 | 0.91 | ion transmembrane transport
GO:0060255 | 0.89 | regulation of macromolecule metabolic process
GO:0031323 | 0.89 | regulation of cellular metabolic process
GO:0010038 | 0.88 | response to metal ion
GO:0010226 | 0.87 | response to lithium ion
GO:0001919 | 0.87 | regulation of receptor recycling
GO:0044710 | 0.83 | single-organism metabolic process
GO:0044260 | 0.83 | cellular macromolecule metabolic process
GO:0016043 | 0.83 | cellular component organization
GO:0051262 | 0.82 | protein tetramerization
GO:0045184 | 0.82 | establishment of protein localization
GO:0031623 | 0.82 | receptor internalization
GO:0010646 | 0.62 | regulation of cell communication
GO:0050804 | 0.60 | modulation of synaptic transmission
GO:0065008 | 0.57 | regulation of biological quality

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 1.00 | cell part
GO:0016020 | 1.00 | membrane
GO:0044425 | 0.95 | membrane part
GO:0044459 | 0.94 | plasma membrane part
GO:1902495 | 0.90 | transmembrane transporter complex
GO:0098797 | 0.90 | plasma membrane protein complex
GO:0043235 | 0.90 | receptor complex
GO:0008328 | 0.89 | ionotropic glutamate receptor complex
GO:0005886 | 0.62 | plasma membrane
GO:0016021 | 0.61 | integral component of membrane
GO:0044456 | 0.58 | synapse part
GO:0098590 | 0.55 | plasma membrane region
GO:0097060 | 0.54 | synaptic membrane
GO:0045202 | 0.54 | synapse
GO:0045211 | 0.53 | postsynaptic membrane
GO:0032281 | 0.50 | AMPA glutamate receptor complex

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.067 | 2vd2A | 0.541 | 3.65 | 0.053 | 0.683 | 2.4.2.17 | 69,103,155,205,212
| 2 | 0.067 | 1ve4A | 0.503 | 3.71 | 0.067 | 0.649 | 2.4.2.17 | 69
| 3 | 0.066 | 1z7mH | 0.500 | 3.86 | 0.056 | 0.653 | 2.4.2.17 | 88,109
| 4 | 0.060 | 2dkfA | 0.438 | 5.82 | 0.057 | 0.727 | 3.1.-.- | NA
| 5 | 0.060 | 2o7qA | 0.441 | 5.82 | 0.072 | 0.727 | 4.2.1.10 1.1.1.25 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.92 | 3pd9A | 0.930 | 1.03 | 0.984 | 0.948 | 1.78 | HA5 | complex1.pdb.gz | 70,98,99,100,105,152,153,154,204,207
| 2 | 0.89 | 2cmoA | 0.834 | 2.34 | 0.961 | 0.941 | 1.50 | M1L | complex2.pdb.gz | 22,25,70,71,72,98,100,105,153,204,207,231
| 3 | 0.81 | 1n0tB | 0.834 | 2.34 | 0.957 | 0.941 | 1.10 | AT1 | complex3.pdb.gz | 22,70,98,99,100,105,231
| 4 | 0.78 | 3h06B | 0.806 | 2.77 | 0.871 | 0.941 | 0.92 | VBP | complex4.pdb.gz | 149,154,185,203,204,207
| 5 | 0.65 | 1yaeB | 0.900 | 1.78 | 0.523 | 0.959 | 1.67 | DOQ | complex5.pdb.gz | 22,69,70,71,98,100,105,149,150,151,152,153,154,185,204
| 6 | 0.55 | 3rnnC | 0.935 | 0.82 | 0.984 | 0.948 | 1.66 | RNN | complex6.pdb.gz | 101,113,114,117,229,230,250,253
| 7 | 0.49 | 3h6wA | 0.940 | 1.06 | 0.977 | 0.959 | 1.73 | NS7 | complex7.pdb.gz | 113,114,116,117,250,258,259,262
| 8 | 0.49 | 3lslA | 0.933 | 0.86 | 0.984 | 0.948 | 1.56 | PZI | complex8.pdb.gz | 44,115,116,253,258,259,262
| 9 | 0.49 | 1ftl0 | 0.859 | 2.05 | 0.984 | 0.945 | 1.76 | III | complex9.pdb.gz | 102,103,106,111,112,113,114,228,246,247,250,251,253,254
| 10 | 0.42 | 1pb8A | 0.860 | 1.85 | 0.317 | 0.919 | 0.83 | DSN | complex10.pdb.gz | 70,98,100,105,153
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.