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# D-I-TASSER results for P61812-D3

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>P61812 (188 residues) EVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARV PEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFK ISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHL LLMLLPSY

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180
| | | | | | | | |
EVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSY
Prediction
CCSSCCSSCCCCCCCCCCCCCCCCCSSSSSSSCCCCCCCCCSSSSSSSSSSSCCCCCCCCCCSSSSSSSSSCCCCCCCCCSSSSSSSSCCCCCCCCSSSSS HHHHHHHHHHCCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCSCSSSSCCCCCCCCCCCCCCCHHHHHHCCCCCCCSSSSSCCCCC
Confidence 95353044146774336643568750899974788989942110223445553688888860899999983477788764246667983688865189997189899997478987169999982887545555655678786221699725787766654200010001112468986998438999
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 | | | | | | | | | EVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSY
Prediction | 84340122312356663476266631120202034136546303300020123437655444231321322446744343220021330445453311213024004313546552110101020644543554544475465413020321455645445444435544655654200000013268
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 | | | | | | | | |
| SS Seq | CCSSCCSSCCCCCCCCCCCCCCCCCSSSSSSSCCCCCCCCCSSSSSSSSSSSCCCCCCCCCCSSSSSSSSSCCCCCCCCCSSSSSSSSCCCCCCCCSSSSS HHHHHHHHHHCCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCSCSSSSCCCCCCCCCCCCCCCHHHHHHCCCCCCCSSSSSCCCCC EVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSY
1 | 3rjrA | 0.23 | 0.16 | 5.01 | 1.00 | DEthreader |  | KEVTRVLMVESGNQIDKFKG-TPHSLYMLFNTLREAVPEPVLLSRA ELRLLR LKLK-V--E-QHVE L Y QKYSQ-----DSWR YLSNRLLAPSDSPE W L S F D V TGVVRQW LTRREAIEG FRLSAH CS--C-----------EINGDLATI---------------------------GMNRP-------
2 | 5ntuA2 | 0.16 | 0.12 | 4.09 | 1.45 | SPARKS-K |  | -----EDDDYHATTETIITMPTEKC---CFFKFSSKIQY-NKVV K AQLWIYLRPVETP--TTVFVQILRLIK-PMKDGTRYTGIRSLKLDMNPTGIWQSID VKTVLQNW LAAPASN L GIEIKALDENGHDLAVTFPGEDGLNPFL EVKVT--DTPKRSRRDF--------------------------
3 | 4ycgA | 0.13 | 0.10 | 3.50 | 1.05 | MapAlign |  | IVRSFSVEDAIS---TAATEDFPFQKHILIFNI-SIPRHE-QITRA ELRLYVSCQDSTHGLEGSMVVYDVLEDSDQATGTKTFLVSQDIRD---EGWETLEVSSA VKRWVRATTNKNKLEVTVQSHRE------------SCDTLDISVP----------------------PGSKNLPFFVVFSND-
4 | 5hlyA2 | 0.18 | 0.13 | 4.17 | 0.90 | CEthreader |  | --SEIITFAESGT-----------ARKTLHFEISKEGSDLSVVERA EVWLFLKVPKANTRTKVTIRLFQQQKH----ERSELLLSEK V VDA-RKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQC--------------QESGASLVLLGEEKEQ------------------SHRPFL LQARQS--
5 | 3rjrA1 | 0.32 | 0.26 | 7.69 | 1.06 | MUSTER |  | E VTRVLMVES--GNQIYDKFKGTPHSLYMLFNTSELREEPVLLSRA ELRLLR LKLK----VE QHVE L Y QKYSQ-----DSWR YLSNRLLAPSDSPE W L S F D V TGVVRQW LTRREAIEG FRLSAH CSCDSKDN-----------TLHVEIN----------G DLAT IHGMNR------PFL L L MATPLE
6 | 3rjrA1 | 0.31 | 0.24 | 7.39 | 3.63 | HHsearch |  | E VTRVLMVESGNQI--YDKFKGTPHSLYMLFNTSELPEP-VLLSRA ELRLLR LKLK----VE QHVE L Y QKYSQ-----DSWR YLSNRLLASDSPE-W L S F D V TGVVRQW LTRREAIEG FRLSAH CSCDSKD-----------NTLHVEINGDL----------AT I------HGMNRPFL L L MATPLE
7 | 5ntuA2 | 0.15 | 0.12 | 4.10 | 1.41 | FFAS-3D |  | --------EDDDYHATTETIITMPTEKCCFFKFSSKIQY-NKVV K AQLWIYLRPVE--TPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSID VKTVLQNW LAAPASN L GIEIKALDENGHDLTFPGPGEDGLNPFL EVKV---TDTPKRSRRDF-------------------------
8 | 5ntuA | 0.13 | 0.12 | 4.05 | 0.90 | EigenThreader |  | TETIITM PTE--------------KCCFFK---FSSKIQYNKVV K AQLWIYLRPV--ETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSID VKTVLQNW LAAPASN L GIEIKALDENGHDLAVTFPGPGEDGLNPIAPYKANECEFVFLAPHTHLVHQAN-PRGSAGPCMLYFNGKEQ
9 | 3rjrA | 0.32 | 0.26 | 7.69 | 1.81 | CNFpred |  | E VTRVLMVE--SGNQIYDKFKGTPHSLYMLFNTSELRPEPVLLSRA ELRLLR LKL----KVE QHVE L Y QKYS-----QDSWR YLSNRLLAPSDSPE W L S F D V TGVVRQW LTRREAIEG FRLSAH CSCDSKD-----------NTLHVEIN----------G DLAT IH------GMNRPFL L L MATPLE
10 | 3rjrA1 | 0.23 | 0.16 | 5.01 | 1.00 | DEthreader |  | KEVTRVLMVESGNQIDKFKG-TPHSLYMLFNTLREAVPEPVLLSRA ELRLLR LKLK-V--E-QHVE L Y QKYSQ-----DSWR YLSNRLLAPSDSPE W L S F D V TGVVRQW LTRREAIEG FRLSAH CS--C-----------EINGDLATI---------------------------GMNRP-------
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.7322
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 4ycgA | 0.66 | 2.82 | 0.137 | 0.771 | model1_4ycgA.pdb.gz
| 2 | 3rjrA1 | 0.64 | 2.73 | 0.280 | 0.745 | model1_3rjrA1.pdb.gz
| 3 | 5hlyA | 0.60 | 2.77 | 0.196 | 0.729 | model1_5hlyA.pdb.gz
| 4 | 5ntuA2 | 0.60 | 2.70 | 0.172 | 0.702 | model1_5ntuA2.pdb.gz
| 5 | 4r4xA | 0.54 | 3.43 | 0.060 | 0.707 | model1_4r4xA.pdb.gz
| 6 | 3ks7D1 | 0.53 | 3.60 | 0.075 | 0.707 | model1_3ks7D1.pdb.gz
| 7 | 2yglA | 0.43 | 3.82 | 0.089 | 0.612 | model1_2yglA.pdb.gz
| 8 | 1xn6A | 0.31 | 5.03 | 0.028 | 0.489 | model1_1xn6A.pdb.gz
| 9 | 2yheA | 0.31 | 5.55 | 0.049 | 0.521 | model1_2yheA.pdb.gz
| 10 | 4ak1A1 | 0.30 | 4.53 | 0.068 | 0.447 | model1_4ak1A1.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0005102 | 0.99 | receptor binding
GO:0005160 | 0.98 | transforming growth factor beta receptor binding
GO:0005114 | 0.85 | type II transforming growth factor beta receptor binding
GO:0034714 | 0.79 | type III transforming growth factor beta receptor binding
GO:0042802 | 0.67 | identical protein binding
GO:0003824 | 0.54 | catalytic activity
GO:0004871 | 0.51 | signal transducer activity
GO:0004672 | 0.51 | protein kinase activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0048522 | 0.99 | positive regulation of cellular process
GO:0044767 | 0.99 | single-organism developmental process
GO:0009987 | 0.99 | cellular process
GO:0080090 | 0.98 | regulation of primary metabolic process
GO:0048583 | 0.98 | regulation of response to stimulus
GO:0044763 | 0.98 | single-organism cellular process
GO:0031325 | 0.98 | positive regulation of cellular metabolic process
GO:0010604 | 0.98 | positive regulation of macromolecule metabolic process
GO:0007165 | 0.98 | signal transduction
GO:0007167 | 0.96 | enzyme linked receptor protein signaling pathway
GO:0007178 | 0.95 | transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0010556 | 0.91 | regulation of macromolecule biosynthetic process
GO:0048523 | 0.85 | negative regulation of cellular process
GO:0009967 | 0.84 | positive regulation of signal transduction
GO:0001934 | 0.84 | positive regulation of protein phosphorylation
GO:0031324 | 0.83 | negative regulation of cellular metabolic process
GO:0007179 | 0.83 | transforming growth factor beta receptor signaling pathway
GO:2000026 | 0.82 | regulation of multicellular organismal development
GO:0048869 | 0.82 | cellular developmental process
GO:0048585 | 0.82 | negative regulation of response to stimulus
GO:0043408 | 0.82 | regulation of MAPK cascade
GO:0010557 | 0.82 | positive regulation of macromolecule biosynthetic process
GO:0009653 | 0.82 | anatomical structure morphogenesis
GO:0051240 | 0.81 | positive regulation of multicellular organismal process
GO:0016043 | 0.81 | cellular component organization
GO:0051241 | 0.80 | negative regulation of multicellular organismal process
GO:0051094 | 0.80 | positive regulation of developmental process
GO:0050896 | 0.80 | response to stimulus
GO:0045778 | 0.80 | positive regulation of ossification
GO:0045597 | 0.80 | positive regulation of cell differentiation
GO:0010033 | 0.79 | response to organic substance
GO:0009719 | 0.79 | response to endogenous stimulus
GO:0051128 | 0.78 | regulation of cellular component organization
GO:0022603 | 0.78 | regulation of anatomical structure morphogenesis
GO:0010720 | 0.78 | positive regulation of cell development
GO:0006950 | 0.78 | response to stress
GO:1901700 | 0.77 | response to oxygen-containing compound
GO:0051130 | 0.77 | positive regulation of cellular component organization
GO:0033993 | 0.77 | response to lipid
GO:0022612 | 0.77 | gland morphogenesis
GO:0014070 | 0.77 | response to organic cyclic compound
GO:0010717 | 0.77 | regulation of epithelial to mesenchymal transition
GO:0009725 | 0.77 | response to hormone
GO:0002683 | 0.77 | negative regulation of immune system process
GO:0048856 | 0.76 | anatomical structure development
GO:0045216 | 0.76 | cell-cell junction organization
GO:0032570 | 0.76 | response to progesterone
GO:0010936 | 0.76 | negative regulation of macrophage cytokine production
GO:0010718 | 0.76 | positive regulation of epithelial to mesenchymal transition
GO:0007435 | 0.76 | salivary gland morphogenesis
GO:0043067 | 0.75 | regulation of programmed cell death
GO:0044707 | 0.74 | single-multicellular organism process
GO:0042981 | 0.73 | regulation of apoptotic process
GO:0042127 | 0.72 | regulation of cell proliferation
GO:0071704 | 0.67 | organic substance metabolic process
GO:0044238 | 0.66 | primary metabolic process
GO:0044237 | 0.66 | cellular metabolic process
GO:0044260 | 0.65 | cellular macromolecule metabolic process
GO:0043085 | 0.62 | positive regulation of catalytic activity
GO:0045859 | 0.61 | regulation of protein kinase activity
GO:0030154 | 0.61 | cell differentiation
GO:0050678 | 0.60 | regulation of epithelial cell proliferation
GO:0045860 | 0.60 | positive regulation of protein kinase activity
GO:0045786 | 0.60 | negative regulation of cell cycle
GO:0043410 | 0.60 | positive regulation of MAPK cascade
GO:0032879 | 0.60 | regulation of localization
GO:0008285 | 0.60 | negative regulation of cell proliferation
GO:0051049 | 0.59 | regulation of transport
GO:0008284 | 0.59 | positive regulation of cell proliferation
GO:0006468 | 0.59 | protein phosphorylation
GO:0060389 | 0.58 | pathway-restricted SMAD protein phosphorylation
GO:0051222 | 0.58 | positive regulation of protein transport
GO:0035303 | 0.58 | regulation of dephosphorylation
GO:0034504 | 0.58 | protein localization to nucleus
GO:0030335 | 0.58 | positive regulation of cell migration
GO:0030155 | 0.58 | regulation of cell adhesion
GO:0071702 | 0.57 | organic substance transport
GO:0045936 | 0.57 | negative regulation of phosphate metabolic process
GO:0045926 | 0.57 | negative regulation of growth
GO:0044765 | 0.57 | single-organism transport
GO:0044710 | 0.57 | single-organism metabolic process
GO:0022402 | 0.57 | cell cycle process
GO:0010634 | 0.57 | positive regulation of epithelial cell migration
GO:0009611 | 0.57 | response to wounding
GO:0097191 | 0.56 | extrinsic apoptotic signaling pathway
GO:0071822 | 0.56 | protein complex subunit organization
GO:0050680 | 0.56 | negative regulation of epithelial cell proliferation
GO:0030308 | 0.56 | negative regulation of cell growth
GO:0030198 | 0.56 | extracellular matrix organization
GO:0007184 | 0.56 | SMAD protein import into nucleus
GO:0007050 | 0.56 | cell cycle arrest
GO:0023014 | 0.55 | signal transduction by protein phosphorylation
GO:0080135 | 0.54 | regulation of cellular response to stress
GO:0001837 | 0.51 | epithelial to mesenchymal transition
GO:0048513 | 0.50 | animal organ development

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044421 | 0.99 | extracellular region part
GO:0005615 | 0.83 | extracellular space
GO:0031012 | 0.71 | extracellular matrix
GO:0044464 | 0.67 | cell part
GO:0005576 | 0.53 | extracellular region
GO:0044424 | 0.51 | intracellular part

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 1ev11 | 0.472 | 4.41 | 0.057 | 0.713 | 3.4.22.28 | 99
| 2 | 0.060 | 2b4kA | 0.503 | 4.14 | 0.052 | 0.713 | 3.1.1.43 | NA
| 3 | 0.060 | 2bbaA | 0.485 | 3.72 | 0.063 | 0.670 | 2.7.10.1 | NA
| 4 | 0.060 | 2v5yA | 0.467 | 3.74 | 0.040 | 0.638 | 3.1.3.48 | NA
| 5 | 0.060 | 1xc6A | 0.437 | 4.13 | 0.139 | 0.649 | 3.2.1.23 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.01 | 2bbaA | 0.485 | 3.72 | 0.063 | 0.670 | 0.15 | III | complex1.pdb.gz | 8,10,30,32
| 2 | 0.01 | 1vrh1 | 0.493 | 4.00 | 0.036 | 0.697 | 0.26 | SD8 | complex2.pdb.gz | 31,33,34,37,46,101,118
| 3 | 0.01 | 2rs31 | 0.492 | 3.92 | 0.044 | 0.692 | 0.20 | W59 | complex3.pdb.gz | 53,95,97,100,118
| 4 | 0.01 | 1k5mA | 0.492 | 3.96 | 0.037 | 0.692 | 0.18 | SPH | complex4.pdb.gz | 53,95,97
| 5 | 0.01 | 2hle0 | 0.494 | 3.58 | 0.048 | 0.660 | 0.14 | III | complex5.pdb.gz | 49,52,145,146,147,149
| 6 | 0.01 | 3juaG | 0.423 | 4.43 | 0.071 | 0.622 | 0.10 | III | complex6.pdb.gz | 96,98,147
| 7 | 0.01 | 2qbxB | 0.471 | 3.86 | 0.065 | 0.654 | 0.16 | III | complex7.pdb.gz | 30,31,32,33,36,116,117,118
| 8 | 0.01 | 3mbw1 | 0.493 | 3.81 | 0.078 | 0.686 | 0.17 | III | complex8.pdb.gz | 96,98,120,180
| 9 | 0.01 | 3mbw0 | 0.493 | 3.81 | 0.078 | 0.686 | 0.18 | III | complex9.pdb.gz | 107,108,109
| 10 | 0.01 | 2rs51 | 0.484 | 3.93 | 0.038 | 0.675 | 0.15 | W56 | complex10.pdb.gz | 95,102,118
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.