D-I-TASSER Q5T848-D1

D-I-TASSER results for Q5T848-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q5T848 (1215 residues)
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAP
WSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHP
SLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPN
QGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEF
RGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYH
PGVLPVNNFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAI
ISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFR
CILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWF
LIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAV
RTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIG
LLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKK
LYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHG
TAKGTALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQE
EETTENSTLESLSGKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQ
KSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQN
SNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVP
SESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCLWESQGQS
ILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENENLNQIGHQ
EKKTSSSEENVRGSYNSSNNFQQPLTSRAEVCPWEFETPAQPNAGRSVALPASSALSANK
IAGPRKEEIWDSFKV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYHPGVLPVNNFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEETTENSTLESLSGKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQNSNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVPSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCLWESQGQSILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENENLNQIGHQEKKTSSSEENVRGSYNSSNNFQQPLTSRAEVCPWEFETPAQPNAGRSVALPASSALSANKIAGPRKEEIWDSFKV
Prediction	CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCSSSSCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHCCCCCHHHCCCCCCCCCCCCCSSCCCCCCCCCSSCCCCCCCCCCSSSSSSSCCCCCCCCCCCCCCSSSSCSCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCSSSSCCCCCSCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCCHHHHHHHHHHHHHHHHHSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCSSCCCHHHHHHHHHHHHHHHHHHHHHSCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Confidence	973189999999997530011478888767889733357777766668764433444577777788863135666552799999974165223211146787666667678886655347899999999999999999986056566751557999999999986177588887653268766653416775304689807751023223566788888763565432233220010123230111555466766541110232578614258887666634888630135577765311545874011111455558987655787656776553332478762147626675898416787878830200342325788766555665552366652789999811213145577899999999999999999999753488715237821459999999999876425752686100268999999999999999999999999865137777664101624678989999999864232211368877778641025556774689861785499999999999999999999984359854340469999999999999999998741589876228999999999999999997443887666541443111210011456656667766787543444445661468999999999999875443320465555544554544444433345676555677764444677777778777667788765566777754344566654456766667777766777776665443445666543455565554434455545566788865565453345666678888876444555666676654455544344455566655567888766556776776667777887777776546888766776666677888777777888787766666444687766555789988877666676657887677888876556788888877677766676444678887788878775556777778777776764456788887778653334677666777766777777665677888888888888898888887765445788767899999877677788877788766778875445798779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYHPGVLPVNNFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEETTENSTLESLSGKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQNSNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVPSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCLWESQGQSILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENENLNQIGHQEKKTSSSEENVRGSYNSSNNFQQPLTSRAEVCPWEFETPAQPNAGRSVALPASSALSANKIAGPRKEEIWDSFKV
Prediction	630100000000000000100021434155345344544346444324144243144422324434344434434452242012001102343044421443141541413244323334203410310121010000001014143441430220010001000211340110000012432211001000210445430202110342331421245331032134434431443213422331424233432211414312002000104434222110000000012132422331201010112023021410344200311120334143212143321333303020210113344442421200002210123121013300101101100011463130012221000000000000000001101000010121110100110000000000000000000000212200000010000000000000000000000000113324222201212000000000000000000000000010234141244244442011100110000000012111100000000000030444131000000001100000000000000011222100000000001111111100000000000111223221332124432344333232333333434434343431342144034104423444243434434544344443333232434434443444344445444444444444435544444444444355554655444456454445444555555654544544554465544644555644664656455644644444464454554556654453545544554544555645444455444454465554555444655645664555564566545456454465465356564465553655466564545645466545455344454564556544565555644544555556646555655555556656556556655565664444556665456666555565555566466665655544644556566455655666556555664565555655666646544646654564455656444454653654656655654566556665565255542454454
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

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SS
Seq

CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCSSSSCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHCCCCCHHHCCCCCCCCCCCCCSSCCCCCCCCCSSCCCCCCCCCCSSSSSSSCCCCCCCCCCCCCCSSSSCSCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCSSSSCCCCCSCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCCHHHHHHHHHHHHHHHHHSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCSSCCCHHHHHHHHHHHHHHHHHHHHHSCCCCCCCCCCCCCCCCCCCCCSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYHPGVLPVNNFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEETTENSTLESLSGKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQNSNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVPSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCLWESQGQSILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENENLNQIGHQEKKTSSSEENVRGSYNSSNNFQQPLTSRAEVCPWEFETPAQPNAGRSVALPASSALSANKIAGPRKEEIWDSFKV

6n51B

0.12

0.06

2.26

0.56

CEthreader

DSCWHSAVALEQSIEFIRDSLISSEEEEGLRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGME--AFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKP--RFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG------SNYKIITMCFSVSLSATVALGCMFVPKVYIIL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6bq1A

0.05

2.13

0.93

EigenThreader

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----GGGGGGGGGGGGGGGGGGG--------------GGGGGGG-----------------GGGGGGGGGGGGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNH--------------------------IHPHLLWS-----------GTVLKTMLDILQTLSLSLSADIHKDQPYYDI---PDAPYRITV---PDTNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKK----DYSNFMASLNLRNRYAGEVYGMIRMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKLHHLCWGPNEHGMETALACWEWLLAGKVPFMREMAGAWHMTVEQKFGLFSAEEVTPHYIWIDFLVQRFEIAKYCSVEIFSSLLQRSMSLN------IGGAKGSMNRHVAAIGPRFKLLTLGLSLLHA-------DVVPNATIRNVLREKIYSTAFDYFIKFWTAMFSDKKRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELD--------QAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLVTRLVRLDPGA------VSDVPEAIKFLV--------TWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQ---------IVQALRYDKMGYVREYILWAASKS-----------QLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGEFDFFNKITNVSAIIKPYPKGDSALSEVKVQPGCYLPSNPEAIVLDIDYPMQSAAKAPYLAKFWQDDC---------RQDMLALQIIDLFKNIFQLVGLDLFVFPYRVTAPGCGVIEC-------IPDCTSRDQLGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKD--------RHNGNIMLDKKGHIIHIDFGFMFESDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQS

4or2A2

0.20

0.04

1.32

1.35

FFAS-3D

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILARKPR----FMSAWAQVIIASILISVQLTLVVTLIIME------PPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG------SNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

7aavA

0.11

0.09

3.39

1.22

SPARKS-K

YLGALKYMPHAVLKLLENMGAISFVNEIPWVIRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEALELDPE------------EDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLAN----QLLTDLVDDNYFYLDLK----AFFTSKALNMAIPGGP---KFEPLVRDI---------NLQD---EDWNEINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRA-------------------------LDIPL----VK-----NWYR--EHCPAG--------------------------QPKYYVLNALKHRPPKAQKKRYLSFKATKFFQ-----------------STKLDWVEVGLQVCRQGYNMLNLLIHRKLDYNFRKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLVDAFQLADGLQYIFAHVGLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAGWRVWLFFMRGITPLLERWRAAVMHDILDMMP---EGIKQNKAR-------------------TILQHLSEAWRCWKANIPWKVPIENMILRYVKAKADWWTNTAHYNRERIRRVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIP----FPPLSYKHD-------TKLLILALERLKEAYSV----KSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQ--RAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRR---------LFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRTAKNNVVINKDMNHTNSYGIIRGLQFASIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPTEHPDPNNENIVGYNNKKCWPRLMKHLPRSVTTVQWENSFVSVYSKDNPNLLNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTADDESMQRFHNRVRQILMASGSTTFTKIVNKWNTAAVVNTQELLDLLVKCENKIQTRIKIGSKMPSRFPPVLGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMS-HEEDQLIPNLYRYIQ------PWEAIAQNRRLTLEDLEQKDRHTLAYDKGWRVRTDFKQYQVLK

6z16D

0.08

0.02

0.77

1.24

CNFpred

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSDSLSALLVLTTSIIALACLVYSFYAIGHKRETFYYYSFFQFLIVGVNGAFTTGDLFNLF-VFFEVMLMSSYVLLV-TIKYTLVNVISSALFVVAVAYLYAVTGTLNMAHLADRILTVIAVLFIIVFGLKGAIFP-----YFWLPGA-------YYAPPTPVLALFGGLLTKVGVYSILRTFTLLFTHDAAYTHTLLAWLALGTIIIYNIIAAVGVMIFGISISVEGTIFYLLQDMVMKAMLFLFVGIIFSITRSN-------------------------IRSFSGLIT-----YPLLGWAFFIAALSLAG---------IPPLSGF------IGKLLIVKAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6jxaA

0.05

0.02

0.96

0.50

DEthreader

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LASEHTKYCDLLRLSLSENRLTISLRLFVEKSCERFILNL-LSKEAWSYNLTI----ELVQDQLSLFDV------------------------------------------------------GSRDKNSWFALKLGTLTYFALNRKNSLLFKRR----------------LEENS--QLKELLF------RMQKNKSQT-S--KI-EE-TE----VLGEKLLCNHYSSSNQAMLLLTSYIEAISDCNDIL-NHIMNSSVSGKLRCRELKYLFVLNLVKSSTLNFI-IREPS-PNSDCGVD-VV--SAAINILKHHVPK-IL-E-KFGYLFEIYECINDGDFLAGLPVPHSIEGVLNR-LF--SL-KATEDSG-YKLEKAKLYIKVAEKSLEKSLLTIFDSRQHFISQ------E--W--MD--TLNAIIEFIKIA-----FPQTLMSIMKADKER----------RHTLMNVLSRNSLDENVK-C---SKYLRLGSIIQL----------------------------------------------------P-----------------------------------------------SESILYDDFKLLINVDQIKARLV------VNWDINVEHSCSDVFYTLGSFLDEQAQKLRSGFENDPWNQIASKILTMLLLPYDSKLPLP-SN--------------R--I------ETVGFNISDGTTQKALMKGSNDD---------------Q--S--------QARKGMKAVQTKSNEERLK----------------------------------------

1vt4I3

0.09

0.04

1.46

1.29

MapAlign

--------LHRSIVDHYNIPKTFDSDDLIPPYLDQYFY----------------------------------------SHIGHHLKNIQKIRHDSTAWNASGSILNTLQQLKFYKPYICDNDPKYERLVNAILDFLPKLRIALMAEEAIFEEAHKQVQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG---GGGGGGGGG---------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-----------GGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGG-------------------------------------------------------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGG---------GGGGG-GGGGGGGGGGGGGGGGGGGGGGG----------------------------------------------------------------------------------------------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGG--------------------------------------------------GGGGGGGGGGGGGGGGGGGGG--------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGG-------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6djyB

0.10

0.09

3.18

1.24

MUSTER

SSITYTSDTT-------NPRITNARTNNDETHATGPIEDLNSTSHGREPEIESFADRAELAGALTVQPMRSIRSTFANLANVLIFH--DVFTTEDKPSAFIEYHSDEMIVNMPKQTYNPI----------------------DNLAKILYLPSLEKF----------KYGTGIVQLNYSPHISKLYQ---------NTNN-----IINTITDGITYANRTEFFIRVMV--LMMMDRKILTMEFYDVDTSAISNTAILPTIPTTTGVSPLL-RIDTRTEPIW---YNDAIKTLITNLTIQY-GKIKTVLDANAYSVVGYPIDQYRAYLY--NHNLLE---YLGK---------KVKREDIMSLIKALSYEFITISDLEYQNIPKWFSDNDLSRF-----FSICMFPD----IVRQFHALNIDYFSQANVFTVKSENAIVKMLNSNQNMEPTIINWFLFRICIDKTVIDDYFSLEMTPIIMRPKL----YDFDMKRGEPVSLLYILELILFSI---------MFPNVTQHMLGQIQARILYISMYAFRQEYLKFITKFGFYYKIV--NGRKEYIQVTN-------------------------QNERMTENNDV----------LTGNLYPSLFTDDPTLSAIA------------TLAKIARLMKP----TTSLTPDDRAIAA---KFPRFKDSAHLNPYSSLNIGGRTQHSVTYTRMYDAIEEMFNLILRAFASSFAQRPRAGVTQLKSLLTQLADPLCLADGHVYHNVMANMMQNFIPNTDGQFHSFRACSGGNIYRVVQNGDELNESLLIDTAIVWGLLGNTDSSYGNAIGATGTANVPTKVQPVIPTPDNFITPTIHLKTSIAICSVEGILLLILSRQTTIPGYEDELNKLRTGISQPKVT-ERQYRRARESIKNMLGSGDYNVAPLHFLLHTEHRSTKLSKRVLDNVVQPYVANLDPAEFENTPQLIENSNMTRLQIALKMLTGDMDDIVKLHKRACAKFD--VYETLTIPTDVKTIV--TMQHISTQTQNNMVYYVFLIDGVKILAEDIKNVNFQIDITGIWPEYVITLLLRAINNGFN-TADVRQFMNTTKAETLLISNKSIVHEIMFFDNALQPKMSSDTLALSEAVYRTSSIITQRISARGLMNLEDARPPEAKISHQSELDMGKIDETTSGLQKMQSSKVSMANVAGSDVIRQAAIKYNVVRTQEI

7ca3B2

0.20

0.04

1.30

3.75

HHsearch

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFK---------IKDQKLLVIVGGMLLIDLCILICWQAV-------DPLRRTVEKAGRDILLEHCENTIWLGIVYAYKGLLMLFGCFLAWETRNVSPALNDSKYIGMSVYNVGIMCIIGAAVSFLT--RDQPNVQFCIVALVIIFCSTITLCLVFVPKLITL-R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

7dttA

0.11

0.05

1.94

0.51

CEthreader

DEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEFRPLCTGDENISSVETPYIDY---------------THLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSI---INWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTS---------CIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFE-----------LSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRQFLL----------------VFLCTFMQIVICVIWLYTAPPSSYRNQEL--------EDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYAS----TYGKFVSAVEVIAILAASFGLLACIFFNKIYI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.4056

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	7dxjA	0.26	8.07	0.034	0.365	model1_7dxjA.pdb.gz
2	5x6oC	0.25	9.30	0.033	0.386	model1_5x6oC.pdb.gz
3	5yz0A	0.25	9.62	0.034	0.393	model1_5yz0A.pdb.gz
4	6z2wE	0.24	9.34	0.023	0.361	model1_6z2wE.pdb.gz
5	6u5vB	0.23	9.38	0.028	0.356	model1_6u5vB.pdb.gz
6	2uvcG	0.23	9.70	0.027	0.357	model1_2uvcG.pdb.gz
7	3jcrA	0.23	9.42	0.024	0.346	model1_3jcrA.pdb.gz
8	6g2dC	0.22	10.24	0.039	0.365	model1_6g2dC.pdb.gz
9	5h64A	0.22	9.11	0.039	0.335	model1_5h64A.pdb.gz
10	6jxaA	0.22	9.66	0.024	0.347	model1_6jxaA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0004871	0.82	signal transducer activity
GO:0099600	0.81	transmembrane receptor activity
GO:0004888	0.80	transmembrane signaling receptor activity
GO:0008066	0.66	glutamate receptor activity

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0065007	1.00	biological regulation
GO:0050794	0.99	regulation of cellular process
GO:0007186	0.96	G-protein coupled receptor signaling pathway

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	1.00	cell part
GO:0016020	0.91	membrane
GO:0005886	0.83	plasma membrane

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	3b9jI	0.064	5.48	0.030	0.076	1.17.1.4 1.17.3.2	NA
2	0.060	2vkzG	0.205	9.88	0.028	0.330	2.3.1.38 3.1.2.14	NA
3	0.060	1w36C	0.163	8.76	0.028	0.240	3.1.11.5	NA
4	0.060	2vz9B	0.189	9.57	0.018	0.291	2.3.1.85	NA
5	0.060	3b9jC	0.126	8.38	0.029	0.181	1.17.3.2 1.17.1.4	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	2qkiD	0.119	8.46	0.009	0.174	0.12	III	complex1.pdb.gz	351,363,364
2	0.01	2xzgA	0.083	7.37	0.030	0.113	0.21	VH1	complex2.pdb.gz	349,351,353,357
3	0.01	2qkiA	0.116	8.56	0.027	0.171	0.12	III	complex3.pdb.gz	357,360,362,363

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.