D-I-TASSER Q5VTQ0-D5

D-I-TASSER results for Q5VTQ0-D5

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q5VTQ0 (292 residues)
NGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQA
YYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSI
PTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAA
LQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLF
ELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| NGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD
Prediction	CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
Confidence	9567899999999981999999999999997045435689999999999999981199999999999995664289999999999997183112457999999999818888763256775899999999999860344401212589999998536544501899999999999999765313323367149999999999999981997999999999998655678886356899999999999819999999999999973778881467779999999999976129
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| NGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD
Prediction	8000011130102226530640151045016346514203000000100000133204401500330163152130000000000001244542562464034004403602541354524023002200540474453423010001000000200430464251043004104501541653654434201300120010000210542650250044005335515532000000000000001447326403510540374276130210032102200530455688
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
NGSLVLFYHARIELLKGNLEEAQEVFQKCISVQEEWKQFHHLCYWELMWINVFQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVVATNENVVTLFRQVDSLKQRIAGKSIPTEKFAVRKARRYSASLPAPVKLILPALEMMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQNFNSFSVDDECLVKLLKGCCLKNLQRPLQAELCYNHVVESEKLLKYDHYLVPFTLFELASLYKSQGEIDKAIKFLETARNNYKDYSLESRLHFRIQAALHLWRKPSSD

4b4tQ

0.07

0.06

2.49

1.17

DEthreader

---------------------------------VKQYNEAEQVYLSLLDKAAAGASVDDRREQETSILELGQLYVKLRFIPHSTEYMMQFA--KSKTVKVLKTLIEKFE-Q--V-PDSLDDQIFVCEKSIEFAK-REK--RVFLKHS--LS-IKLATLHYQK-K-QYKDSLALINDLLREFK-KLD--DK-PSLVDVHLLESKVYHKLRNLAKSKASLTAARTAANSIYCPTQTVAELDLMSGILHCEDKDYKTAFSYFFESFESYHNLTNSYEKACQVLKYMLLSKIMLNT

4eqfA

0.11

0.09

3.36

1.36

SPARKS-K

KDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGD----AEAWQFLGITQAENENEQAAIVALQRCLELQPNNL-KALMALAVSYTNTSHQ------QDACEALKNWIKQNPKYKYLDSSVLEGVKELYLEAAHQNG------DMIDPDLQTGLGVLFHLSG--EFNRAIDAFNAALTVR----------PEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP-------GFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSG---NIWAALRIALSLMDQPELF

5o09C

0.12

4.20

0.74

MapAlign

LLTGIYSLLAHLYDRWGRMDKAAEFYELALKISALEEDKVATIKNNLAMIFKQLRKFERAEGYYCEALETLSARVASVYNNLGVLYYSH------MDVDRAQVMHERALAIAYHDPIRVGALVEQISVLADLRQKRAQELRKQDPDLLTGIYSLLAHLYDR--WGRMDKAAEFYELALKISAENGL--EESDKVATIKNNLAMIFKQLRKFERAEGYYCEALETFQRLDGESARVASVYNNLGVLYYSHMDVDRAQVMHERALAIRQNLQMDPADLSQTFINLGAVYKAA--

4a1sA

0.10

3.64

0.49

CEthreader

SMCLELALEGERLCNAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHDLTLARLGEAKSSGNLGNTLKVMGR------FDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYHAKGKHLGMRDLGDRGAQGRACGNLGNTYYLLGDFQAAIEHHQERLRIAREFG----DRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELG-EREVEAQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQDRIGEARACWSLGNAHSAIGGHERA

6vbu8

0.12

0.11

3.96

1.12

MUSTER

KDWWWKVQIGKCYYRLGLYREAEKQFKSALKQQEM-----VDTFLYLAKVYISLDQPLTALNLFKQGLDKFPGE-VTLLCGIARIYEEMNN------ISSATEYYKEVLKQDNT-HVEAIACIGSNHFYTDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEE-------EVADVWYNLGHVAVGTGDTNLAHQCFRLALVSNNQH-------AEAYNNLAVLEMRRGHVEQAKALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYAA

5o09C

0.13

4.38

0.78

HHsearch

KVATIKNNLAMIFKQLRKFERAEGYYCEALETGEQSA-RVASVYNNLGVLYYSHMDVDRAQVMHERALAIRA-DLSQTFINLGAVYKAAGDFQ------KAEACVDRAKRIRAAMNGDTISVLADLRQKEGDFRKAEREALRKQDPDLTGIYSLLAHLYDRW--GRMDKAAEFYELALKISAENG--LEESDKVATIKNNLAMIFKQLRKFERAEGYYCEALETFQRLDGQSARVASVYNNLGVLYYSHMDVDRAQVMHERALAIRQNPADLSQTFINLGAVYKAAGDFQKA

4ynvA

0.11

0.10

3.70

2.03

FFAS-3D

-NPKELLDRATTLLEEGDIETAAKVARTAYEHIGENGRHAGAALTLLGQIHVELGDIDAARNYYAAAVKVDEDGSLPEELGGGPEKFLWLAQLSEEGGHDSVAWFERGATVLRAQIQSLDSLEQRVEAAIADKRR-------------RLAETLCAVVEVYTDLSWEDDAEQRCEALITEA-------TIAPEWPETWQTVANVRISQERTEEAREALRRSLGLWTHLPPEDPGVFPSRVSLVRLLIEVD-EEEALEVTERLIAEDDLSVEVWYLGGYARYRLGEKEREAS-

3sf4A

0.11

3.92

0.83

EigenThreader

ASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLAKALEYHHHDLTLARTIGD-QLGEAKASGNLGNTLKVLGN---FDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGGEGDKAAERRAYSNLGNAYIFLGE--FETASEYYKKTLLLARQL----KDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELN-DRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDELTARLNLSDLQMVLGLSYST

5a6cA

0.12

4.10

1.47

CNFpred

ASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLAQLGEAKASGNLGNTLKVL------GNFDEAIVCCQRHLDISRELNDK-PEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEF----GDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQL-KDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQDRIGEGRACWSLGNAYTALGNHDQA

5mpbQ

0.07

0.06

2.40

1.17

DEthreader

-----------------------------A---YNEAEQVYLSLLDKDSSQSSAGAREQSILELGQLYVTMGKKLREFIPHSTEYMMQFAKS-K--TVKVLKTLIEKFEQV---PD-SLDDQIFVCEKSIEFAKREK---RVFLKHSLSIKLATLHYQK-K----QYKDSLALINDLLREFKK-L-D--DKPSLVDVHLLESKVYHKLRNLAKSKASLTAARTAANSIYCPTQTVAELDLMSGILHCEDKDYKTAFSYFFESFESYHNLTNSYEKACQVLKYMLLSKIMLNL

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.7326

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	4a1sA	0.79	2.74	0.107	0.931	model1_4a1sA.pdb.gz
2	5dseA	0.76	2.88	0.129	0.894	model1_5dseA.pdb.gz
3	3sf4A	0.73	3.21	0.080	0.901	model1_3sf4A.pdb.gz
4	5u1sA	0.73	3.85	0.054	0.928	model1_5u1sA.pdb.gz
5	3zgqA	0.72	3.55	0.076	0.897	model1_3zgqA.pdb.gz
6	5udiA	0.71	3.80	0.086	0.914	model1_5udiA.pdb.gz
7	4kvmA	0.71	3.99	0.117	0.911	model1_4kvmA.pdb.gz
8	2gw1A	0.70	3.99	0.098	0.901	model1_2gw1A.pdb.gz
9	6af0A1	0.70	3.77	0.069	0.887	model1_6af0A1.pdb.gz
10	4bujB	0.69	3.66	0.086	0.877	model1_4bujB.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0036094	0.52	small molecule binding
GO:0097159	0.51	organic cyclic compound binding
GO:0003824	0.50	catalytic activity

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0009987	0.93	cellular process
GO:0044699	0.87	single-organism process
GO:0044763	0.82	single-organism cellular process
GO:0065007	0.76	biological regulation
GO:0008152	0.75	metabolic process
GO:0050789	0.74	regulation of biological process
GO:0050794	0.73	regulation of cellular process
GO:0044767	0.72	single-organism developmental process
GO:0016043	0.72	cellular component organization
GO:0071704	0.71	organic substance metabolic process
GO:0044238	0.69	primary metabolic process
GO:0044237	0.69	cellular metabolic process
GO:0043170	0.66	macromolecule metabolic process
GO:0044260	0.64	cellular macromolecule metabolic process
GO:0022607	0.63	cellular component assembly
GO:0006996	0.63	organelle organization
GO:0044710	0.62	single-organism metabolic process
GO:0019222	0.61	regulation of metabolic process
GO:0080090	0.59	regulation of primary metabolic process
GO:0060255	0.59	regulation of macromolecule metabolic process
GO:0031323	0.59	regulation of cellular metabolic process
GO:0019538	0.58	protein metabolic process
GO:0044267	0.57	cellular protein metabolic process
GO:0010468	0.57	regulation of gene expression
GO:0033043	0.56	regulation of organelle organization
GO:0031326	0.56	regulation of cellular biosynthetic process
GO:0019219	0.56	regulation of nucleobase-containing compound metabolic process
GO:0006464	0.56	cellular protein modification process
GO:0051179	0.55	localization
GO:0048519	0.55	negative regulation of biological process
GO:0006355	0.55	regulation of transcription, DNA-templated
GO:1902589	0.54	single-organism organelle organization
GO:0051246	0.54	regulation of protein metabolic process
GO:0048523	0.54	negative regulation of cellular process
GO:0006807	0.54	nitrogen compound metabolic process
GO:1901360	0.53	organic cyclic compound metabolic process
GO:0048583	0.53	regulation of response to stimulus
GO:0048518	0.53	positive regulation of biological process
GO:0046483	0.53	heterocycle metabolic process
GO:0044281	0.53	small molecule metabolic process
GO:0034641	0.53	cellular nitrogen compound metabolic process
GO:0033044	0.53	regulation of chromosome organization
GO:0031399	0.53	regulation of protein modification process
GO:0007165	0.53	signal transduction
GO:0048856	0.52	anatomical structure development
GO:0044723	0.52	single-organism carbohydrate metabolic process
GO:0031060	0.52	regulation of histone methylation
GO:0006139	0.52	nucleobase-containing compound metabolic process
GO:0051641	0.51	cellular localization
GO:0051569	0.51	regulation of histone H3-K4 methylation
GO:0048869	0.51	cellular developmental process
GO:0048522	0.51	positive regulation of cellular process
GO:0006486	0.51	protein glycosylation
GO:0050896	0.50	response to stimulus

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044424	1.00	intracellular part
GO:0044444	0.96	cytoplasmic part
GO:0043226	0.93	organelle
GO:0043229	0.89	intracellular organelle
GO:0044446	0.88	intracellular organelle part
GO:0043227	0.81	membrane-bounded organelle
GO:0043231	0.80	intracellular membrane-bounded organelle
GO:0016020	0.72	membrane
GO:0005829	0.71	cytosol
GO:0005737	0.70	cytoplasm
GO:0043234	0.67	protein complex
GO:0005634	0.67	nucleus
GO:0044428	0.63	nuclear part
GO:0005654	0.50	nucleoplasm

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.066	1w3bA	0.667	3.32	0.103	0.829	2.4.1.-	NA
2	0.066	1w3bB	0.632	3.51	0.094	0.805	2.4.1.-	222
3	0.060	2qnoA	0.506	5.46	0.051	0.774	3.2.1.4	283
4	0.060	1rw9A	0.509	5.81	0.050	0.812	4.2.2.5	NA
5	0.060	2ri9B	0.552	4.94	0.074	0.798	3.2.1.113	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.08	3fp2A	0.662	4.17	0.085	0.884	0.96	III	complex1.pdb.gz	200,203,206,218,237,241,278
2	0.05	3hymB	0.663	3.85	0.071	0.846	0.41	III	complex2.pdb.gz	15,46,50,53,145,149,150,153,195,196,199,202,204,213,237,238,240,244,247,252
3	0.04	3hymF	0.674	3.71	0.067	0.849	0.49	III	complex3.pdb.gz	80,84,87,130,133,134,152,156,194,199,200,203,206,207,211,235,237,238,240,244,247,248,276,280,281,284,288
4	0.02	1hz40	0.656	4.16	0.069	0.884	0.50	III	complex4.pdb.gz	209,241,244,249
5	0.01	2xpiD	0.602	4.64	0.078	0.846	0.41	III	complex5.pdb.gz	153,154,157,160,174,196,197,200,203,204,207,235,237,240,241,247,259,278,282,285,288,289
6	0.01	1f59A	0.558	5.61	0.041	0.884	0.54	III	complex6.pdb.gz	199,202,203,206,207,240,244

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.