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# D-I-TASSER results for Q5VU97-D1

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q5VU97 (1108 residues) MARQPEEEETAVARARRPPLWLLCLVACWLLGAGAEADFSILDEAQVLASQMRRLAAEEL GVVTMQRIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTS PLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKS NPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVT DTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTF VSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKA TLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIK GSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLL GIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHY ENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSF ILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAG SFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQME MSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVG GAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFI MEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQR FYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLN CHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCV NSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGA IGDEVITLNMIKSAPVGPVAGGIMGCIM

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100
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Prediction
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCSSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCSSSCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCSSSSSSSCCCCCCCCHHHHHHHHHHHHHHHCCCCCSSSSSSSCCCCSSCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCSSSSSSSCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCSSCCCCCCCCCCHHHHHHHHHHHHCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSSCCCSSSSSSSSSSS HHHHHHHHHHCCCCCCSSSSSSCCCCCSSSCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCSSSSSSCCCCCCSSCCCCSSSCCCCCSSSSSSSCCCCCSSSSSSSSCCCCHHHHHHCCCCCCCCCCCCCCCSSSCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCSSSSSSCCCCCSSSCCCCCCCCCCCCCCCHHHHHHHHCCCCSSSSCCSSSCCCCCSSSSSSSSSSCCCCCCCCCCSSSSSSSSSCHHHHHHHHHHHHHHCCCCCCCCSSSSSSCCCCSSSSCCCCCCCCCCCCCCCCCCCCHCHHHHHHHHHHHHHHHHHHHCCCCCCCSSSSSSSSSCCCCCCCCCCCCCCSSSSSSSSCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCSSSCSCCCCCCCCCCCCCCCHHHHCCCSSCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHH SSSSSC
Confidence
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Prediction |
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCSSSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCSSSCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCSSSSSSSCCCCCCCCHHHHHHHHHHHHHHHCCCCCSSSSSSSCCCCSSCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCSSSSSSSCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCSSCCCCCCCCCCHHHHHHHHHHHHCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSSCCCSSSSSSSSSSS HHHHHHHHHHCCCCCCSSSSSSCCCCCSSSCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCSSSSSSCCCCCCSSCCCCSSSCCCCCSSSSSSSCCCCCSSSSSSSSCCCCHHHHHHCCCCCCCCCCCCCCCSSSCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCSSSSSSCCCCCSSSCCCCCCCCCCCCCCCHHHHHHHHCCCCSSSSCCSSSCCCCCSSSSSSSSSSCCCCCCCCCCSSSSSSSSSCHHHHHHHHHHHHHHCCCCCCCCSSSSSSCCCCSSSSCCCCCCCCCCCCCCCCCCCCHCHHHHHHHHHHHHHHHHHHHCCCCCCCSSSSSSSSSCCCCCCCCCCCCCCSSSSSSSSCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCSSSCSCCCCCCCCCCCCCCCHHHHCCCSSCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHH SSSSSC
1 | 7jpkF | 0.18 | 0.15 | 4.71 | 4.15 | SPARKS-K |  | ----------------------------------FPSAVTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYLY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWREEVVYEPGSQRIKPVFIDDAN FRRQV SYQHAAVHIPTDIYEGELNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWVDIDLYDVRRR PWYIQGAAS-PKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDV---SCFQ-HLVQANVRNKKVLKDAVNNIT-AKGITDYKKG FSFA FEQL---LNYNVSRA NCNKIIMLFTDGGEE------RAQEIFAKYNK-----DKKVRVFTFSVGQHNYD----RGPIQWMACEN---------------K GYYYEIPSIGAIRINTQEYLDVLGRPLAKQVQWTNVYLDALELG LVITGTLPVFNIQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLQPKPINLQEPVTLDFLDAEENDIKVEIRNKMIDGESGEKTFRTLVKS--------QDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAK-----------------IEETITQARYSETLKPDNFEESG--YTFLAPRDYCPSDNNTEFLLNFNEFIDRKTPNNCNTDLINRVLLDAGFTNELVQNWSK----QKNIKGVKARFVVTDGGITRVY PKENWQENPETYEDSFYKRSLDND-NYVFTAP YFNKSGYESGIMVSKAVEIYIQ--GKLLKPA VVG IKIDVNSWIENFTK---DCKR-NSDVMDCVILDDGGFLLMANH----DDYTNQIGRFFGEIDPSLMRHLVNI-SVYAFNKSYDYQSVCEQTQYFFDND-SKSFSGVLDCGNC SIFHVEKLMNT NLIFIMVESKGT----CPC-------------DTR--------LLIQAE------QTSDGPDPCDMVKQPRYRKGP--------DVCFDNN--VLEDYTD C---------------------------------------------------------------------------
2 | 3jbrF | 0.10 | 0.07 | 2.70 | 1.33 | EigenThreader |  | ---------------------------------GGGGGGGGGGVHQLVDIYEKYQD----------------LY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWREDFASNEVVYYNA--KDDLDPEKNDSEPGSQHAAVHIPTDIYEGSWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWNKIDLYDVRRR-PWYIQGAASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCF----QHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQ LLN----YNVSRA NCNKIIMLFTDGGEERAQEIFAKYN-----------KDKKVRVFTFSVGQHNYDRGPIQWMACEN-----KGYYYEIPSIGAIRIN-------TQEYLDVLG RPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMG--VDVSLEDIKRLTPRFTLCPNGYPNLQPKPPKSQEPVTLDFLDAELENDIKVEIRNKMIDGES-------GEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSSLALVLPTYSFYYIKA-----------------KIEETITQARYSETLKPDGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGG-------------------------------------------GGGGGGGGGGGGG-----------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGCITEQTQYFFDNDDCGNCSRIFHVEKLMNTNLIFIPCDTRLLIQAEQTSD-------GPDPCDMVKQPRYRKGPDVCFD----------------------
3 | 7jpkF | 0.17 | 0.13 | 4.40 | 2.13 | MapAlign |  | --------------------------------------VTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYLY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWRNEVVYYNAKQRIKPVFIDDAN FRRQV SYQHAAVHIGSTIVLNELNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDV--SCF--QHLVQANVRNKKVLKDAVNNIT-AKGITDYKKG FSFA FEQL---LNYNVSRA NCNKIIMLFTDGGE-------ERQEIFAKYNKDK-----KVRVFTFSVGQH----NYDRGPIQWMACEN---------------K GYYYEIPSIGAIRINTQEYLDVLGRPMAKQVQWTNVYLDALELG LVITGTLPVFNNQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PRPNVQNPKSQEPVTLDFLDALENDIKVEIRNKMIDGESGEKTFRTLVKSQDER--------YIDKGNRTYTWTPVNGTDYSLALVLPTYSFYY--------------IKAKIEETITQARYSETLKPDNFEESGYTFLA-PRDYCSDLKPSDNNTEFLLNFNEFI--DRKTPNN PSCNTDLINRVLLDAGFTNELVQNWSKQKNIKGVKARFVVTDGGITRVY PKEAGQENPETYEDSFYKRSLD-NDNYVFTAP YFKSGPGAYGIMVSKAVEIYI--QGKLLKPA VVG IKIDVNSWIENFT----KDCKRNSDVMDCVILDDGGFLLMANHDD----YTNQIGRFFGEIDPSLMRHLVN-ISVYAFNKSYDQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNT NLIFIMVEST CPCDTRLLIQAEQTSDGPDPCDMVKQPRY-----------------------------------------------------------------------------------------------------------------------------------------
4 | 6emkA | 0.06 | 0.03 | 1.10 | 0.50 | DEthreader |  | -ALADNSPYLLAKCIELILVSIGDIAFEVGISPYMLILDNIRERFLNKDLLNTLILNKSSTVNSLNQSFMKCFLQLIHHQTSDLFIKDALHSVSELPDNLRLLF-------------------------------------------------------------L-FSNMPKKKEESATLQASSAVAALLKELMPLIATYELLGILINILKNNPHIRRG--------DSAIGILKHAQQHNEL QL--KETWYEKL------QRWEDALAAYNEKEAAGKLRSLYALGEWEELSKLASEKWGTAKPEVKKA-----------------------------KSQSPDKEFYDAIHIFNARDLLVTELS-AL------RAYNVVRAIIELEITWRL-GCQ----------------------------------TW-KISLSESSSLGTWLELPLIRIHQPNQIVSRSLSLS---------LVYPLMVAIK-SESLSRQKAA--LSIIEKMRIHSPVLVDQAEL----------------LELQHVSPKLLFEPVFSVISSKQR-----------------------HEDIRQDSLVMQLFGLVNT-------------------------------------------------------------------------------DTFHVLIRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HREAKK--I--L-IE-HWVMLQMAPDYDNLTLQKVEVFREKFPEK------------------------------------------------------------------------PVMN----------------ELLSNGTEVQRVE---------
5 | 7jpkF | 0.18 | 0.14 | 4.67 | 1.23 | CEthreader |  | ----------------------------------FPSAVTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYQY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWREDFDSEPGSQRIKPVFIDDAN FRRQV SYQHAAVHIPTDIYENELNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWVDNDLYDVRRR PWYIQGA-ASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSC----FQHLVQANVRNKKVLKDAVNNIT-AKGITDYKKG FSFA FEQLLNYN---VSRA NCNKIIMLFTDGGEER------AQEIFAKYNK-----DKKVRVFTFSVGQH----NYDRGPIQWMACEN---------------K GYYYEIPSIGAIRINTQEYLDVLGRPMAKQVQWTNVYLDALELG LVITGTLPVFNIQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLNVQNPKSQEPVTLDFLDAELENIKVEIRNKMIDGESGEKTFRTLVKS--------QDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKI-------------EETITQARYSETLKPDNFEE SGYTFLAPRDYCSDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWS---KQKNIKGVKARFVVTDGGITRVY PKENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPA VVG IKIDVNSWIENFTK----DCKRNSDVMDCVILDDGGFLLMA----NHDDYTNQIGRFFGEIDPSLMRHLVNIS-VYAFNKSYDYQSITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNT NLIFIMVESKGT----CPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDC----------------------------------------------------------------------------------------------------------------
6 | 5gjvF | 0.19 | 0.15 | 4.75 | 3.04 | MUSTER |  | ----------------------------------FPSAVTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYLY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWREDFASVVYYNAKKPVFIDDAN FRRQV SYQHAAVHIPTDIYEGELNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWVKIDLYDVRRR PWYIQGA-ASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD---VSCFQ-HLVQANVRNKKVLKDAVNNIT-AKGITDYKKG FSFA FEQLLNY---NVSRA NCNKIIMLFTDGGEER------AQEIFAKYNK-----DKKVRVFTFSVGQHNY----DRGPIQWMACEN---------------K GYYYEIPSIGAIRINTQEYLDVLGGDKAKQVQWTNVYLDALELG LVITGTLPVFNNQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLQPKPPKSQEPVTLDFLDAELENIKVEIRNKMIDGESGEKTFRTLVKS--------QDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSF----------------YYIKAKIEETITQARYSETLKPEE SGYTFLAPRDYCSDLKP--SDNNTEFLLNFNEFIDRKT-----TDLINRVLLDAGFTNELVQNYWS---KQKNIKGVKARFVVTDGGITRVY PKEAWQENPETYEDSFYKRSLDNDN-YVFTAP YFNKGAYESGIMVSKAVEIYIQ--GKLLKPA VVG IKIDVNSWIENFTKTSIRM--------DCVILDDGGFLLMANHDDYTN----QIGRFFGEIDPSLMRHLVNISVY-AFNKSYDYQSITEQTQYFFDND-SKSFSGVLDCGNCRIFHVEKLMNT NLIFIMVESKGT----CPCDTR--------LLIQAE------------------QTSDGPDP-CDMVKQPRY---------KGPDVCFDNNVLEDYT--D C---------------------------------------------------------------------------
7 | 7jpkF | 0.19 | 0.15 | 4.93 | 6.71 | HHsearch |  | ----------------------------------FPSAVTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYLY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWREDVVSEPGSQRKPV-FIDDAN FRRQV SYQHAAVHIPTDIYENELNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWVDIDLYDVRRR PWYIQGA-ASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ---DVSCFQ-HLVQANVRNKKVLKDAVNNIT-AKGITDYKKG FSFA FEQLLNYN---VSRA NCNKIIMLFTDGGEE------RAQEIFAKYNK-----DKKVRVFTFSVGQHN----YDRGPIQWMACE---------------NK GYYYEIPSIGAIRINTQEYLDVLGRPMAKQVQWTNVYLDALELG LVITGTLPVFNNQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLQPKPPKSQEPVTLDFLDAELENDKVEIRNKMIDGESGEKTFRTLVKS--------QDERYIDKGNRTYTWTPVNGTDYSLALVLPTY----------------SFYYIKAKIEETITQARYSETLDNFE SGYTFLAPRDYCSDLKPSDN--NTEFLLNFNEFIDRKTPPSCNTDLINRVLLDAGFTNELVQYWSKQK----NIKGVKARFVVTDGGITRVY PKENWQENPETYEDSFYKRSLDND-NYVFTAP YFNKSAYESGIMVSKAVEIYIQ--GKLLKPA VVG IKIDVNSWIENFTK---DCKR-NSDVMDCVILDDGGFLLMANHD-DYT---NQIGRFFGEIDPSLMRHLVNI-SVYAFNKCEPGAAITEQTQYFFDNDSK-SFSGVLDCGNC SRFHVEKLMNT NLIFIMVESKGT----CPCDTR-LLIQ----AE QSDGPDP CDMVKQP------RYR-------------------------KGPDVCFDNNVLEDY--TD C---------------------------------------------------------------------------
8 | 7jpkF | 0.19 | 0.15 | 4.93 | 5.20 | FFAS-3D |  | ----PSAVT-------------------------------IKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYQY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWREKNDSEPGSQRIKPVFIDDAN FRRQV SYQHAAVHIPTDIYEGSLNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWVDNDLYDVRRR PWYIQGA-ASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDV---SCF-QHLVQANVRNKKVLKDAVNNIT-AKGITDYKKG FSFA FEQLLNYNVS---RA NCNKIIMLFTDGGEE------RAQEIFAKYNK-----DKKVRVFTFSVGQHNYDR----GPIQWMACENKGYY---------------YEIPSIGAIRINTQEYLDVLAGDKAKQVQWTNVYLDALELG LVITGTLPVFNNQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLQPKPIKSQEPVTLDFLDAELENDIVEIRNKMIDGESGEKTFRTLVKSQ--------DERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEET-------------------ITQARYSET LKPDNFEESGYTFLAPRDYCSDLKPTEFLLNFNEFIDRKTPNNCNTDLINRVLLDAGFTNELVQNYWSKQKN---IKGVKARFVVTDGGITRVY P GENWQENPETYEDSFYKRSLDNDNYV-FTAP YFNKSGPGSGIMVSKAVEI--YIQGKLLKPA VVG IKIDVNSWIENFTKDCKRN----SDVMDCVILDDGGFLLMANH----DDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNT NLIFIMVESK--------------------------GTC P CDTRL-----LIQAEQTSDGPDPCDMVKQPRYRKGPD--------VCFDNN--VLEDYTD C---------------------------------------------------------------------------
9 | 7jpkF | 0.13 | 0.10 | 3.55 | 1.67 | EigenThreader |  | ----------------------------------FPSAVTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYQDLVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWRSNEVVYYNAKDDL---DPEKNDSEPGYQHAAV-HIPTDIYEGSTIVLNEL NWTSALNREEDPSLWQVFGSATGLARYYPASPWVDNSIDLYDVRRRPWYIQGAASPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCF----QHLVQANVRNKKVLKDAVN-NITAKGITDYKKG FSFA FEQL---LNYNVSRA NCNKIIMLFTDGGEERAQEIFAKYN-----------KDKKVRVFTFSVGQHNYDRGPIQWMACEN-------------------K GYYYEIPSIGAIRINTQGRPMVLAGDKAKQVQWTNVYLDALELG LVITGTLPVFNITLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLSQEPVTLDFLDAELE-----NDIKVEIRNKMIDGESGEKTFRTLVKQDERY---------IDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAK----IEETITQARYSETLKPDNFEESGYTFAPRDYC--------SDLK-----PSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKGAYESGIMVSKAVYI-------QGKLLKVVG IKIDVNSWIENFTK----DCKRNSDVMDCVIDDGGFLLMA----NHDDYTNQIGRFFGEIDPSLMRHLVNI--SVYAFNKSYDY----QSVCEQYFFDNDSKDCGN----CSRIFHVEKLMNT NLIFIMVESKGTCPCDTRLLIQAEGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDC------------------------------------------------------------------------------------------------------------------------
10 | 5gjvF | 0.19 | 0.14 | 4.47 | 5.17 | CNFpred |  | --------------------------------------VTIKSWVDKMQEDLVTL AKTASG VHQLVDIYEKYLY TVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAA HQWRE-VVYYNAK-RIKPVFIDDAN FRRQV SYQHAAVHIPTDIYE-ELNWTSALDDVFKKNREEDPSLLW QVFGSATGLARYYP ASPWV-IDLYDVRRR PWYIQGAA-SPKDMLILVDVSGS VSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD---VSCFQ-HLVQANVRNKKVLKDAVNNITAK-GITDYKKG FSFA FEQLLNYNV---SRA NCNKIIMLFTDGGEE------RAQEIFAKYNKD-----KKVRVFTFSVGQHNY----DRGPIQWMACEN---------------K GYYYEIPSIGAIRINTQEYLDVLGRPMAKQVQWTNVYLDALELG LVITGTLPVFNNQLIL GVMG V D VSLEDIKRLTPRFTLCPNGYYFAI DPNG YVLLH PNLQPKPIGV-EPVTLDFLDAELENIKVEIRNKMIDGESGEKTFRTLVKSQ--------DERYIDKGNRTYTWTPVNGTDYSSLALVLPTYSFYYIKAKIEETITQARYSETLKP----DNFEE--------SGYTFLAPRDYCSDLKPS--DNNTEFLLNFNEFIDRKT-----TDLINRVLLDAGFTNELVQNYWSKQ---KNIKGVKARFVVTDGGITRVY PKEAWQENPETYEDSFYKRSLDND-NYVFTAP YFNKGAYESGIMVSKAVEIYI--QGKLLKPA VVG IKIDVNSWIENFTKTSIR--------MDCVILDDGGFLLMANHDDYT-----QIGRFFGEIDPSLMRHLVN-ISVYAFNKSYDYQSITEQTQYFFDNDS-KSFSGVLDCGNC SRFHVEKLMNT NLIFIMVESKG----TCPCDTR----------------------------------------------------------------------------------------------------------------------------------------------------------
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.6064
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 7jpkF | 0.78 | 1.39 | 0.178 | 0.794 | model1_7jpkF.pdb.gz
| 2 | 3jbrF | 0.61 | 3.81 | 0.120 | 0.665 | model1_3jbrF.pdb.gz
| 3 | 6reyc | 0.30 | 9.68 | 0.056 | 0.487 | model1_6reyc.pdb.gz
| 4 | 6uebA | 0.30 | 9.61 | 0.044 | 0.477 | model1_6uebA.pdb.gz
| 5 | 6um1A | 0.30 | 9.46 | 0.043 | 0.475 | model1_6um1A.pdb.gz
| 6 | 4xqkA | 0.29 | 8.76 | 0.030 | 0.426 | model1_4xqkA.pdb.gz
| 7 | 6fb3A | 0.29 | 9.22 | 0.047 | 0.447 | model1_6fb3A.pdb.gz
| 8 | 6h3iA | 0.29 | 9.44 | 0.041 | 0.456 | model1_6h3iA.pdb.gz
| 9 | 5a22A | 0.28 | 9.22 | 0.075 | 0.440 | model1_5a22A.pdb.gz
| 10 | 5lewA | 0.28 | 7.89 | 0.044 | 0.400 | model1_5lewA.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0098772 | 0.75 | molecular function regulator
GO:0005246 | 0.74 | calcium channel regulator activity
GO:0005262 | 0.67 | calcium channel activity
GO:0005244 | 0.67 | voltage-gated ion channel activity
GO:0005245 | 0.65 | voltage-gated calcium channel activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0065007 | 0.97 | biological regulation
GO:0050789 | 0.94 | regulation of biological process
GO:0051179 | 0.90 | localization
GO:0006810 | 0.88 | transport
GO:0006816 | 0.85 | calcium ion transport
GO:0051049 | 0.83 | regulation of transport
GO:0043269 | 0.76 | regulation of ion transport
GO:0051924 | 0.75 | regulation of calcium ion transport
GO:0070588 | 0.73 | calcium ion transmembrane transport
GO:0065008 | 0.52 | regulation of biological quality

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 1.00 | cell part
GO:0044425 | 0.95 | membrane part
GO:0032991 | 0.95 | macromolecular complex
GO:0043234 | 0.94 | protein complex
GO:0044459 | 0.92 | plasma membrane part
GO:0098797 | 0.91 | plasma membrane protein complex
GO:0005891 | 0.89 | voltage-gated calcium channel complex
GO:0016020 | 0.70 | membrane
GO:0044424 | 0.55 | intracellular part
GO:0005886 | 0.54 | plasma membrane

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 1q16A | 0.254 | 9.23 | 0.030 | 0.396 | 1.7.99.4 | NA
| 2 | 0.060 | 2ckjA | 0.250 | 8.85 | 0.031 | 0.377 | 1.17.1.4 1.17.3.2 | NA
| 3 | 0.060 | 2q1fA | 0.253 | 8.72 | 0.041 | 0.376 | 4.2.2.21 | NA
| 4 | 0.060 | 2hpiA | 0.283 | 8.32 | 0.034 | 0.412 | 2.7.7.7 | NA
| 5 | 0.060 | 2vkzG | 0.265 | 9.04 | 0.030 | 0.402 | 2.3.1.38 3.1.2.14 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
No Binding sites was predicted
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.