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# D-I-TASSER results for Q8TER0-D4

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q8TER0 (122 residues) TAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSY TCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSC AS

Predicted Secondary Structure

Sequence

20 40 60 80 100 120
| | | | | |
TAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCAS
Prediction
CCCCCCCCCCCCCCCSSSCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCSSSSCCCCCSCCCCCCCCCCCCCCCCCCCCCSSSCCCCCSSSSCCCCCSCCCCCCCCCCCCCC
Confidence 99887898988899689837994798849996015863784789988889688816994898858995358776467756679998899589837993798868996358777798867889
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 | | | | | | TAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCAS
Prediction | 86444454414334033314554043434442416414234046413524033424554043423541426315443354047315535124454554044414644427437275435668
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 | | | | | |
| SS Seq | CCCCCCCCCCCCCCCSSSCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCSSSSCCCCCSCCCCCCCCCCCCCCCCCCCCCSSSCCCCCSSSSCCCCCSCCCCCCCCCCCCCC TAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCAS
1 | 4c16A | 0.14 | 0.11 | 3.89 | 0.83 | DEthreader |  | -----SYYWIGVGTKLKNWAPEMWN---------ALCYTAACTNTSCSGHGECVETINNY T CKCDPG FSGLKC EQIVNCT-ALE-SPGIETMQCMSSGEWSA-------PIPACN-VVE-CD
2 | 2vj3A | 0.30 | 0.29 | 8.70 | 3.49 | SPARKS-K |  | DVDECSLANPCEHAGKCINTLG SFECQCLQGYTGPRIDVNECVSNP CQNDATCLDQIGEFQCICMPGYEGVH C E-VNTDECASSP CLHNGRCLDKINEFQCEC PTGF T GHLCQVDLH-----
3 | 2vj3A | 0.31 | 0.29 | 8.68 | 0.79 | MapAlign |  | -VDECSLANPCEHAGKCINTLG SFECQCLQGYTGPRCDVNECVSNP CQNDATCLDQIGEFQCICMPGYEGVH C EVNT-DECASSP CLHNGRCLDKINEFQCEC PTGF T GHLCQVDL------
4 | 2vj3A | 0.30 | 0.29 | 8.70 | 0.70 | CEthreader |  | DVDECSLANPCEHAGKCINTLG SFECQCLQGYTGPRCEIDECVSNP CQNDATCLDQIGEFQCICMPGYEGVH C EVNT-DECASSP CLHNGRCLDKINEFQCEC PTGF T GHLCQVDLH-----
5 | 4xbmB | 0.42 | 0.41 | 12.05 | 2.24 | MUSTER |  | DLNYCTHHKPCKNGATCTNTG G S YTCSCRPGYTGATCEIDEC DPSP CKN G G S CTDLENS YSCTC PPG FYG KIC EL-SAMTCADG P CFN G GRCSDSPGGYSCRC PVGYSGFNC EK-KIDYCSS
6 | 4xbmB | 0.39 | 0.39 | 11.39 | 1.80 | HHsearch |  | DLNYCTHHKPCKNGATCTNTQG S YTCSCRPGYTGATLGIDEC DPSP CKN G G S CTDLENS YSCTC PPG FYG KIC EL-SAMTCADG P CFN G GRCSDSPDGYSCRC PVGYSGFNC EKK-IDYCSS
7 | 2vj3A | 0.30 | 0.29 | 8.70 | 1.14 | FFAS-3D |  | DVDECSLANPCEHAGKCINTLG SFECQCLQGYTGPRCEVNECVSNP CQNDATCLDQIGEFQCICMPGYEGVH C EVNTDE-CASSP CLHNGRCLDKINEFQCEC PTGF T GHLCQVDLH-----
8 | 2vj3A | 0.29 | 0.28 | 8.48 | 1.08 | EigenThreader |  | VDECSLGANPCEHAGKCINTLG SFECQCLQGYTGPRCEINECVSNP CQNDATCLDQIGEFQCICMPGYEGVH C EVNTD-ECASSP CLHNGRCLDKINEFQCEC PTGF T GHLCQVDLH-----
9 | 5mwbA | 0.34 | 0.32 | 9.57 | 3.95 | CNFpred |  | DVDECAMANPCEHAGKCVNTDGAFHCECLKGYAGPEMDINECHS D P CQNDATCLDKIGGFT CLCMPG FKGVH C ELEI-NECQSNP CVNNGQCVDKVNRFQCLC PPGF T GPVCQID-------
10 | 5uk5A | 0.21 | 0.19 | 6.01 | 0.83 | DEthreader |  | TIDDCASAACFQGATCHDRV--ASFYCECPHTGLLCHLNDACISNP C-NESNC DTNPVKAICTC PSGYTGPACSQDVDEC----C-HAGKCLNTL-GSFECQCLQGYT G RCE-DVQIGEFQC
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.5693
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 2vj3A | 0.86 | 1.44 | 0.302 | 0.951 | model1_2vj3A.pdb.gz
| 2 | 5mwbA | 0.85 | 1.40 | 0.342 | 0.934 | model1_5mwbA.pdb.gz
| 3 | 5uk5A | 0.72 | 2.65 | 0.272 | 0.934 | model1_5uk5A.pdb.gz
| 4 | 4xbmB | 0.65 | 2.88 | 0.265 | 0.787 | model1_4xbmB.pdb.gz
| 5 | 1yo8A | 0.65 | 3.32 | 0.179 | 0.959 | model1_1yo8A.pdb.gz
| 6 | 4d90A | 0.61 | 2.90 | 0.330 | 0.738 | model1_4d90A.pdb.gz
| 7 | 6xp5N | 0.53 | 4.56 | 0.050 | 0.902 | model1_6xp5N.pdb.gz
| 8 | 4qo6A | 0.53 | 4.59 | 0.043 | 0.910 | model1_4qo6A.pdb.gz
| 9 | 1n7dA | 0.48 | 3.94 | 0.112 | 0.770 | model1_1n7dA.pdb.gz
| 10 | 2bo2A | 0.47 | 4.35 | 0.179 | 0.869 | model1_2bo2A.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0046872 | 0.88 | metal ion binding
GO:0005509 | 0.87 | calcium ion binding
GO:0005102 | 0.87 | receptor binding
GO:0005112 | 0.81 | Notch binding
GO:1901363 | 0.77 | heterocyclic compound binding
GO:0097159 | 0.77 | organic cyclic compound binding
GO:0004872 | 0.75 | receptor activity
GO:0044877 | 0.72 | macromolecular complex binding
GO:0046983 | 0.71 | protein dimerization activity
GO:0019899 | 0.71 | enzyme binding
GO:0004857 | 0.71 | enzyme inhibitor activity
GO:0003676 | 0.71 | nucleic acid binding
GO:0046982 | 0.70 | protein heterodimerization activity
GO:0003700 | 0.70 | transcription factor activity, sequence-specific DNA binding
GO:0043565 | 0.69 | sequence-specific DNA binding
GO:0031490 | 0.69 | chromatin DNA binding
GO:0001190 | 0.69 | transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001047 | 0.69 | core promoter binding
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0044699 | 0.96 | single-organism process
GO:0065007 | 0.95 | biological regulation
GO:0050789 | 0.94 | regulation of biological process
GO:0050794 | 0.93 | regulation of cellular process
GO:0032502 | 0.93 | developmental process
GO:0009987 | 0.92 | cellular process
GO:0044767 | 0.89 | single-organism developmental process
GO:0044763 | 0.89 | single-organism cellular process
GO:0048583 | 0.85 | regulation of response to stimulus
GO:0009653 | 0.85 | anatomical structure morphogenesis
GO:2000026 | 0.84 | regulation of multicellular organismal development
GO:0048518 | 0.84 | positive regulation of biological process
GO:0032501 | 0.84 | multicellular organismal process
GO:0048523 | 0.83 | negative regulation of cellular process
GO:0048522 | 0.83 | positive regulation of cellular process
GO:0045595 | 0.83 | regulation of cell differentiation
GO:0044707 | 0.83 | single-multicellular organism process
GO:0023051 | 0.83 | regulation of signaling
GO:0010646 | 0.83 | regulation of cell communication
GO:0060284 | 0.82 | regulation of cell development
GO:0048856 | 0.82 | anatomical structure development
GO:0022603 | 0.82 | regulation of anatomical structure morphogenesis
GO:0009966 | 0.82 | regulation of signal transduction
GO:0048584 | 0.81 | positive regulation of response to stimulus
GO:0045664 | 0.81 | regulation of neuron differentiation
GO:0051241 | 0.80 | negative regulation of multicellular organismal process
GO:0051093 | 0.80 | negative regulation of developmental process
GO:0009967 | 0.80 | positive regulation of signal transduction
GO:0007165 | 0.80 | signal transduction
GO:0050768 | 0.79 | negative regulation of neurogenesis
GO:0008593 | 0.79 | regulation of Notch signaling pathway
GO:0003002 | 0.79 | regionalization
GO:0002009 | 0.79 | morphogenesis of an epithelium
GO:0097150 | 0.78 | neuronal stem cell population maintenance
GO:0045995 | 0.78 | regulation of embryonic development
GO:0045747 | 0.78 | positive regulation of Notch signaling pathway
GO:0045665 | 0.78 | negative regulation of neuron differentiation
GO:0030856 | 0.78 | regulation of epithelial cell differentiation
GO:0009952 | 0.78 | anterior/posterior pattern specification
GO:0003143 | 0.78 | embryonic heart tube morphogenesis
GO:0070986 | 0.77 | left/right axis specification
GO:0045662 | 0.77 | negative regulation of myoblast differentiation
GO:0045608 | 0.77 | negative regulation of auditory receptor cell differentiation
GO:0016043 | 0.77 | cellular component organization
GO:0014807 | 0.77 | regulation of somitogenesis
GO:0007386 | 0.77 | compartment pattern specification
GO:0001947 | 0.77 | heart looping
GO:0048869 | 0.76 | cellular developmental process
GO:0007166 | 0.76 | cell surface receptor signaling pathway
GO:0051128 | 0.74 | regulation of cellular component organization
GO:0080090 | 0.73 | regulation of primary metabolic process
GO:0060255 | 0.73 | regulation of macromolecule metabolic process
GO:0050896 | 0.73 | response to stimulus
GO:0048513 | 0.73 | animal organ development
GO:0031323 | 0.73 | regulation of cellular metabolic process
GO:0006928 | 0.73 | movement of cell or subcellular component
GO:0051179 | 0.72 | localization
GO:0048589 | 0.72 | developmental growth
GO:0022604 | 0.72 | regulation of cell morphogenesis
GO:0090287 | 0.71 | regulation of cellular response to growth factor stimulus
GO:0051240 | 0.71 | positive regulation of multicellular organismal process
GO:0051094 | 0.71 | positive regulation of developmental process
GO:0048646 | 0.71 | anatomical structure formation involved in morphogenesis
GO:0048585 | 0.71 | negative regulation of response to stimulus
GO:0032879 | 0.71 | regulation of localization
GO:0030154 | 0.71 | cell differentiation
GO:0030030 | 0.71 | cell projection organization
GO:0023057 | 0.71 | negative regulation of signaling
GO:0010769 | 0.71 | regulation of cell morphogenesis involved in differentiation
GO:0010648 | 0.71 | negative regulation of cell communication
GO:0009893 | 0.71 | positive regulation of metabolic process
GO:0006355 | 0.71 | regulation of transcription, DNA-templated
GO:0060560 | 0.70 | developmental growth involved in morphogenesis
GO:0051130 | 0.70 | positive regulation of cellular component organization
GO:0048858 | 0.70 | cell projection morphogenesis
GO:0048468 | 0.70 | cell development
GO:0045597 | 0.70 | positive regulation of cell differentiation
GO:0042127 | 0.70 | regulation of cell proliferation
GO:0040008 | 0.70 | regulation of growth
GO:0031325 | 0.70 | positive regulation of cellular metabolic process
GO:0022414 | 0.70 | reproductive process
GO:0016477 | 0.70 | cell migration
GO:0010604 | 0.70 | positive regulation of macromolecule metabolic process
GO:0009968 | 0.70 | negative regulation of signal transduction
GO:0009888 | 0.70 | tissue development
GO:0007219 | 0.70 | Notch signaling pathway
GO:0006810 | 0.70 | transport
GO:1902531 | 0.69 | regulation of intracellular signal transduction
GO:0051270 | 0.69 | regulation of cellular component movement
GO:0050790 | 0.69 | regulation of catalytic activity
GO:0048638 | 0.69 | regulation of developmental growth
GO:0044765 | 0.69 | single-organism transport
GO:0044702 | 0.69 | single organism reproductive process
GO:0042981 | 0.69 | regulation of apoptotic process
GO:0040012 | 0.69 | regulation of locomotion
GO:0032101 | 0.69 | regulation of response to external stimulus
GO:0031324 | 0.69 | negative regulation of cellular metabolic process
GO:0010720 | 0.69 | positive regulation of cell development
GO:0010628 | 0.69 | positive regulation of gene expression
GO:0010605 | 0.69 | negative regulation of macromolecule metabolic process
GO:0010033 | 0.69 | response to organic substance
GO:0007409 | 0.69 | axonogenesis
GO:0006950 | 0.69 | response to stress
GO:0006357 | 0.69 | regulation of transcription from RNA polymerase II promoter
GO:0002376 | 0.69 | immune system process
GO:2000146 | 0.68 | negative regulation of cell motility
GO:1902533 | 0.68 | positive regulation of intracellular signal transduction
GO:1901700 | 0.68 | response to oxygen-containing compound
GO:0071310 | 0.68 | cellular response to organic substance
GO:0061314 | 0.68 | Notch signaling involved in heart development
GO:0060627 | 0.68 | regulation of vesicle-mediated transport
GO:0060429 | 0.68 | epithelium development
GO:0051301 | 0.68 | cell division
GO:0051272 | 0.68 | positive regulation of cellular component movement
GO:0050920 | 0.68 | regulation of chemotaxis
GO:0050769 | 0.68 | positive regulation of neurogenesis
GO:0048754 | 0.68 | branching morphogenesis of an epithelial tube
GO:0048639 | 0.68 | positive regulation of developmental growth
GO:0048545 | 0.68 | response to steroid hormone
GO:0048514 | 0.68 | blood vessel morphogenesis
GO:0045893 | 0.68 | positive regulation of transcription, DNA-templated
GO:0045892 | 0.68 | negative regulation of transcription, DNA-templated
GO:0045765 | 0.68 | regulation of angiogenesis
GO:0045165 | 0.68 | cell fate commitment
GO:0044087 | 0.68 | regulation of cellular component biogenesis
GO:0043066 | 0.68 | negative regulation of apoptotic process
GO:0042246 | 0.68 | tissue regeneration
GO:0040017 | 0.68 | positive regulation of locomotion
GO:0035295 | 0.68 | tube development
GO:0035107 | 0.68 | appendage morphogenesis
GO:0030855 | 0.68 | epithelial cell differentiation
GO:0030513 | 0.68 | positive regulation of BMP signaling pathway
GO:0022404 | 0.68 | molting cycle process
GO:0021515 | 0.68 | cell differentiation in spinal cord
GO:0015031 | 0.68 | protein transport
GO:0010810 | 0.68 | regulation of cell-substrate adhesion
GO:0010770 | 0.68 | positive regulation of cell morphogenesis involved in differentiation
GO:0010594 | 0.68 | regulation of endothelial cell migration
GO:0009790 | 0.68 | embryo development
GO:0009605 | 0.68 | response to external stimulus
GO:0008285 | 0.68 | negative regulation of cell proliferation
GO:0008284 | 0.68 | positive regulation of cell proliferation
GO:0007276 | 0.68 | gamete generation
GO:0006952 | 0.68 | defense response
GO:0003006 | 0.68 | developmental process involved in reproduction
GO:0002682 | 0.68 | regulation of immune system process
GO:0002064 | 0.68 | epithelial cell development
GO:0001889 | 0.68 | liver development
GO:0000904 | 0.68 | cell morphogenesis involved in differentiation
GO:2001027 | 0.67 | negative regulation of endothelial cell chemotaxis
GO:2000974 | 0.67 | negative regulation of pro-B cell differentiation
GO:2000811 | 0.67 | negative regulation of anoikis
GO:2000737 | 0.67 | negative regulation of stem cell differentiation
GO:1902263 | 0.67 | apoptotic process involved in embryonic digit morphogenesis
GO:1901201 | 0.67 | regulation of extracellular matrix assembly
GO:0090090 | 0.67 | negative regulation of canonical Wnt signaling pathway
GO:0090051 | 0.67 | negative regulation of cell migration involved in sprouting angiogenesis
GO:0072602 | 0.67 | interleukin-4 secretion
GO:0072144 | 0.67 | glomerular mesangial cell development
GO:0072044 | 0.67 | collecting duct development
GO:0072017 | 0.67 | distal tubule development
GO:0071372 | 0.67 | cellular response to follicle-stimulating hormone stimulus
GO:0061419 | 0.67 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0060982 | 0.67 | coronary artery morphogenesis
GO:0060979 | 0.67 | vasculogenesis involved in coronary vascular morphogenesis
GO:0060956 | 0.67 | endocardial cell differentiation
GO:0060948 | 0.67 | cardiac vascular smooth muscle cell development
GO:0060843 | 0.67 | venous endothelial cell differentiation
GO:0060768 | 0.67 | regulation of epithelial cell proliferation involved in prostate gland development
GO:0060740 | 0.67 | prostate gland epithelium morphogenesis
GO:0060528 | 0.67 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060412 | 0.67 | ventricular septum morphogenesis
GO:0060271 | 0.67 | cilium morphogenesis
GO:0060253 | 0.67 | negative regulation of glial cell proliferation
GO:0060045 | 0.67 | positive regulation of cardiac muscle cell proliferation
GO:0050679 | 0.67 | positive regulation of epithelial cell proliferation
GO:0050434 | 0.67 | positive regulation of viral transcription
GO:0048715 | 0.67 | negative regulation of oligodendrocyte differentiation
GO:0048711 | 0.67 | positive regulation of astrocyte differentiation
GO:0048103 | 0.67 | somatic stem cell division
GO:0046533 | 0.67 | negative regulation of photoreceptor cell differentiation
GO:0046427 | 0.67 | positive regulation of JAK-STAT cascade
GO:0045955 | 0.67 | negative regulation of calcium ion-dependent exocytosis
GO:0045668 | 0.67 | negative regulation of osteoblast differentiation
GO:0045618 | 0.67 | positive regulation of keratinocyte differentiation
GO:0045603 | 0.67 | positive regulation of endothelial cell differentiation
GO:0045070 | 0.67 | positive regulation of viral genome replication
GO:0043086 | 0.67 | negative regulation of catalytic activity
GO:0043065 | 0.67 | positive regulation of apoptotic process
GO:0035914 | 0.67 | skeletal muscle cell differentiation
GO:0035148 | 0.67 | tube formation
GO:0035116 | 0.67 | embryonic hindlimb morphogenesis
GO:0032496 | 0.67 | response to lipopolysaccharide
GO:0032495 | 0.67 | response to muramyl dipeptide
GO:0031960 | 0.67 | response to corticosteroid
GO:0031100 | 0.67 | organ regeneration
GO:0031069 | 0.67 | hair follicle morphogenesis
GO:0030900 | 0.67 | forebrain development
GO:0030514 | 0.67 | negative regulation of BMP signaling pathway
GO:0030335 | 0.67 | positive regulation of cell migration
GO:0030324 | 0.67 | lung development
GO:0021915 | 0.67 | neural tube development
GO:0010832 | 0.67 | negative regulation of myotube differentiation
GO:0010812 | 0.67 | negative regulation of cell-substrate adhesion
GO:0010718 | 0.67 | positive regulation of epithelial to mesenchymal transition
GO:0009912 | 0.67 | auditory receptor cell fate commitment
GO:0007492 | 0.67 | endoderm development
GO:0007440 | 0.67 | foregut morphogenesis
GO:0007283 | 0.67 | spermatogenesis
GO:0007221 | 0.67 | positive regulation of transcription of Notch receptor target
GO:0006959 | 0.67 | humoral immune response
GO:0003344 | 0.67 | pericardium morphogenesis
GO:0003273 | 0.67 | cell migration involved in endocardial cushion formation
GO:0003270 | 0.67 | Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003256 | 0.67 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003241 | 0.67 | growth involved in heart morphogenesis
GO:0003222 | 0.67 | ventricular trabecula myocardium morphogenesis
GO:0003219 | 0.67 | cardiac right ventricle formation
GO:0003214 | 0.67 | cardiac left ventricle morphogenesis
GO:0003213 | 0.67 | cardiac right atrium morphogenesis
GO:0003198 | 0.67 | epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003192 | 0.67 | mitral valve formation
GO:0003184 | 0.67 | pulmonary valve morphogenesis
GO:0003180 | 0.67 | aortic valve morphogenesis
GO:0003169 | 0.67 | coronary vein morphogenesis
GO:0003162 | 0.67 | atrioventricular node development
GO:0003160 | 0.67 | endocardium morphogenesis
GO:0002437 | 0.67 | inflammatory response to antigenic stimulus
GO:0002052 | 0.67 | positive regulation of neuroblast proliferation
GO:0001701 | 0.67 | in utero embryonic development
GO:0000122 | 0.67 | negative regulation of transcription from RNA polymerase II promoter
GO:0008152 | 0.63 | metabolic process
GO:0071704 | 0.61 | organic substance metabolic process
GO:0044238 | 0.59 | primary metabolic process
GO:0044237 | 0.59 | cellular metabolic process
GO:0043170 | 0.59 | macromolecule metabolic process
GO:0044260 | 0.57 | cellular macromolecule metabolic process
GO:0009058 | 0.54 | biosynthetic process
GO:0006807 | 0.54 | nitrogen compound metabolic process
GO:0044249 | 0.53 | cellular biosynthetic process
GO:0009059 | 0.53 | macromolecule biosynthetic process
GO:0006139 | 0.53 | nucleobase-containing compound metabolic process
GO:0016070 | 0.52 | RNA metabolic process
GO:0032774 | 0.51 | RNA biosynthetic process

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 0.83 | cell part
GO:0044424 | 0.63 | intracellular part
GO:0044421 | 0.61 | extracellular region part
GO:0016020 | 0.45 | membrane
GO:0031012 | 0.43 | extracellular matrix
GO:0043226 | 0.42 | organelle
GO:0044444 | 0.36 | cytoplasmic part
GO:0043227 | 0.36 | membrane-bounded organelle
GO:0043229 | 0.32 | intracellular organelle
GO:0005886 | 0.32 | plasma membrane

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 2q1fA | 0.347 | 5.13 | 0.036 | 0.656 | 4.2.2.21 | NA
| 2 | 0.060 | 1igrA | 0.417 | 5.12 | 0.076 | 0.795 | 2.7.10.1 | 46,50,62,76,96
| 3 | 0.060 | 2dewX | 0.416 | 4.96 | 0.025 | 0.803 | 3.5.3.15 | NA
| 4 | 0.060 | 2gajB | 0.408 | 5.00 | 0.071 | 0.762 | 5.99.1.2 | 52
| 5 | 0.060 | 2uv8G | 0.429 | 5.08 | 0.033 | 0.803 | 2.3.1.86 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.12 | 1w0yL | 0.493 | 3.85 | 0.210 | 0.738 | 1.63 | FUC | complex1.pdb.gz | 50,52,63,64,65
| 2 | 0.07 | 2c4fL | 0.501 | 3.77 | 0.208 | 0.746 | 1.48 | FUC | complex2.pdb.gz | 89,90,91,102,104
| 3 | 0.03 | 1dvaL | 0.370 | 2.11 | 0.193 | 0.418 | 1.40 | UUU | complex3.pdb.gz | 80,83,97,98,99,110
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.