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# D-I-TASSER results for Q8TF62-D1

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q8TF62 (956 residues) MFCSEKKLREVERIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYF LCLLILQLIPEISSLTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINS KLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSSEPHGLCYVETAELDGETNLKVRHALS VTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWKDSKHSLNNEKIILRGCILRNTS WCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNSIWES QTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWD RKMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDD LDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVHEFLRLLALCHTVMSE ENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNT RKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAY RDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQEGVIETV TSLSLANIKIWVLTGDKQETAINIGYACNMLTVICCRVTPLQKAQVVELVKKYRNAVTLA IGDGANDVSMIKSAHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKF LCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGIFDQDVSDQ NSVDCPQLYKPGQLNLYPTLSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQE GYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFSQDKTVKL

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940
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Prediction
CCCCCCCCCCCCSSSSSCCCHHHHHCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSSCCCCSSSSS HHHCCCCCSSSSSCCCCCCCSSSSSSSCCCCCCSSSSSCCCCCCCCCCSCCCCHHHHHHCCCHHHHHCCCSSSSSCCCCCCCCSSSSSSSSCCCCCCCCCCSSSSSCCSSSSSCSSSSSSSSSCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSCCCCCCCHHHHHHHHHHHHHHHHHCCCCSSS HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCSSSCCCCHHHCCCSSSSSSCCCCCCCCCCSSSSSSSSCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCSSSCCCCCSSSSCCCCCHHHHHHHHHHHCCSSSSCCCCSSSSSSCCSSSSSSSSSSSCCCCCCCSSSSSSSCCCCCSSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH SSSSSSSSCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCSSSSSSSSCCCCCHHHHHHHHHHHHCCCSSSSSSCCHHHHHHHHHHHHCCCCCSSSSSCHHHHHHHHHHHHHHCCSSSSSSCCCHHHHHHHHHCCSSSSSCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
Confidence
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Prediction |
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCCCCCCCCCCCSSSSSCCCHHHHHCCCCCCSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSSCCCCSSSSS HHHCCCCCSSSSSCCCCCCCSSSSSSSCCCCCCSSSSSCCCCCCCCCCSCCCCHHHHHHCCCHHHHHCCCSSSSSCCCCCCCCSSSSSSSSCCCCCCCCCCSSSSSCCSSSSSCSSSSSSSSSCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCSSSSCCCCCCCHHHHHHHHHHHHHHHHHCCCCSSS HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCSSSCCCCHHHCCCSSSSSSCCCCCCCCCCSSSSSSSSCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCSSSCCCCCSSSSCCCCCHHHHHHHHHHHCCSSSSCCCCSSSSSSCCSSSSSSSSSSSCCCCCCCSSSSSSSCCCCCSSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH SSSSSSSSCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCSSSSSSSSCCCCCHHHHHHHHHHHHCCCSSSSSSCCHHHHHHHHHHHHCCCCCSSSSSCHHHHHHHHHHHHHHCCSSSSSSCCCHHHHHHHHHCCSSSSSCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
1 | 7bspA | 0.31 | 0.24 | 7.15 | 1.00 | DEthreader |  | ------------------------------------------------K--FEQFRRIANFYFL IIFLV---------PTSGLPLFFVITVTAIKQGYEDWLRHR-AD--VNKSTVYIIERVRKESE-KIK V G DVVEVQADETF-CD LIL L S SCTTDGTC Y VTT-SL D--E---KTHYA-VRDTIALCTAESILRAAI----------------I-IYSEAVARSLGPENLLLGATLKNTKIYGVAVYTGMET KMALNYQGKSQK RSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSTNDEQKTQKERETL-VLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSF-F---ISW DKDFYDEEINEGALVNTSDL N E E L G QVDYVFTD K T G T L TENSMEFIECCIDGHKY-------------K---V-----------------------D-KNREELFLRALCLC-HTVEIKTNDAVDGSAETYISS P D EIA L VKGAKRYG FTFLGNRNGYMRVENRKEIEEYEL LHTLNFDAVRRR M S V I VKTQE GDILLFCK G A DSAVFP-RV--QNHEIEL TKVHVERNAMDGYR T LCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDI ETNMNLIG A T A V E D K L QDQAAE TIEALHAAGLKVW V L T G D KME T AKSTCY A CRLFAVLC C RMAP L Q K A QIVRMV KNLKSPIT LSI G D G A N D V S M ILESHVGIG IKGGRQAARNSDYSVPK--FKHLKKL L LAH GHLYYVRIAHLVQY F F Y K NLCFILPQFLYQF F C G F SQQPLY DAAYLTMYN ICFT S L PIL AYSLLEQHINIDTLTSDPRL YMKISAMKLALDTRFWNH---------------------------------L--IL------------------------ILLIV----N---------------V-R
2 | 6k7gA | 0.42 | 0.39 | 11.51 | 4.23 | SPARKS-K |  | ----------EVRTIFINQP---QLTKFCNNHVSTAK Y N IIT F L PRFLYSQ FRRAA NSFF LFIALL QQI PDVSPTGRYT TLV P LLFILAVAAIKEIIEDIKR H KAD NAV NKKQTQV LRNGAWEIVHWEKVNV G D IVIIKGKEYIPA DTVL L S S S E PQAMC YIE TSNL D G E T N L KIRQGLPAT SD-IKDVDSLMRISGRIEC ESP NRHLYDFVGNIR-----VPLGADQILL R GAQL R N TQWVHGIVVYTGHD T K L M Q N STSPPLKLSNVERITNVQILILFCIL IAMSLVCSVGSAI WNRRHSGKDWYLNLNYGGASNF----GLNFLTFI ILFNNLIP I S LLVTLE VVKFTQAY F I N W DLDMHYEPTDTAAMA R TSNL N E E L G QVKY I F S D K T G T L TCNVMQF KKCTIAGVAY GQNF-----------------------------SDSSLLENLQNNHAPIICE F LTMMAVC H TAVPE-RERDKII Y QAAS P D E G A L VRA AKQLNFVFTGR T PDSVIIDSL GQEERYEL LNVLEFTSAR K R M S V I V RTPSGKLRL YCK G A D TVIYDRLAETSKY-KEITLKH LEQF ATE G L R T LCFAVAEISESDFQE WRAVYQRASTSVQNRLLKLEESY ELI EKNLQL L G A T AIE D K L QDQVPE TIETLMKADI K I WIL T G D K Q E T A I N I GHSCKLLKV I C C R VSP L Q KSEV V EMV K KQVKVV T L A I G D G A N D V S M IQTA HVG V G I S GNE G L Q AANSS D Y SIA Q FKY LKNL LMIH GAWNYNRVSKCILYCF Y K NIVLYIIEIW FAFVNG F SGQILFERWCIGLYNVMFTAMPPLTLG I FERSCRKENMLKYPEL Y KTSQNALDFNNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNITVCLKAGLETSYWTVFFGIYSSLWPAIPMAP-DMSGEAAMLFSSGVFWMGLLFIPVASLL
3 | 6lcpA | 0.37 | 0.36 | 10.75 | 1.97 | MapAlign |  | ----------APRKLYFNKDEEGHPIQQFPRNKIRTAKYTPLSFIPKNLWFQFNIA NIFF LFLVI LVIFPIFGGVNPGLNSV P LIVII TVT AIK D AIED YRRTILDIELN NAPVHRLSGARFHKDAWKNLVV G DFVRIYNDDELPA DIIILATSDPDGAC Y V E TKNL D G E T N L K V RQA LRCGRTL-KHARDCERAQFVIESEPPQPNLYKYNGAIRW KEMSEPIGIDNLLL R G CHL R N TEWALGVVVFTGHD T KIMMNAGITPSK RARIARELNFNVICNF GILLIMCLIAA IANGIAWGKTDASLAWFEYGS-IGGTPALTG FIT F WAAVIVFQNLV P I S L YISLEIVRTLQAFF IYSDVGM Y YEKIDQPCIPKSWNISDDVG Q I E Y I F S D K T G T L T Q NVMEF KKATI N GQPY G EAYTEAQAGMDRRRGINVELHDNPYLHDEDMTFIAPDFVEDLAEQQQATEHFMLAL A L C H T VVAEKQPGDPPMIFKAQP D EAA L VATA RDMG FTVLGMSDGGINVNVMGKDMHFPVLSIIEF NSSR K R M STI V RMPDGRILLFCK G A DSVIYSRLKGEQADMRRETAQH LEMF AVE G L R T LCI AERELSEEEYRE WRREHDLAATALENREEKLEEVADKI E R D LTL L GGT AIE DRL QDG VPDTIALLADAGI KLW V L T G D KVE T A I N I GFSC NLLSVLC C R VSPAQ K AAV VSMV KNGLDVMT LSI G D G A N D VAM IQEADVG V G IAGEE GRQ A VMSS DFAIGQ F RFL Q R LVL V H G R W S YRRLAETISNF F Y K NMIWTWSIF WYQCYCNFDIAYIFEYTYILMF NLFFT SVP VILM GVLD Q D V S DTVSLAVP Q L YRRGIKEWTQTKFWLYMIDGVYQSVMSFFIPFIFVVLTPTAAGNGLDVSERTRLGAYIAHPAVITINGYILINTYRWDWLMLLSIVLSDVFIFFWTG-----------
4 | 6lcpA | 0.38 | 0.37 | 11.10 | 0.90 | CEthreader |  | ----APRKLYFNLPPELKDEEGHPIQQFPRNKIRTAK YTPLSFIPKN LWFQ FHNIA NIFF LFLVI LVIFPIFGGVNPGLNSV P LIVII TVT AIK D AIED YRRTILDIELN NAPVHRLSKARFHKDAWKNLVV G DFVRIYNDDELPA DIIILATSDPDGAC Y V E TKNL D G E T N L K V RQA LRCG-RTLKHARDCERAQFVIESEPPQPNLYKYNGAIRW KEMSEPIGIDNLLL R G CHL R N TEWALGVVVFTGHD T KIMMNAGITPSK RARIARELNFNVICNF GILLIMCLIAA IANGIAWGKTDASLAWFEYGSI-GGTPALTG FIT F WAAVIVFQNLV P I S L YISLEIVRTLQAFF IYSDVGM Y YEKIDQPCIPKSWNISDDVG Q I E Y I F S D K T G T L T Q NVMEF KKATI N GQPY G EAYTEAQAGMGLRELHDNPYLHDEDMTFIAPDFVEDLAGKNGPEQQQATEHFMLAL A L C H T VVAEKQDPPKMIFKAQ S P D EAA L VATA RDMG FTVLGMSDGGINVNVMGKDMHFPVLSIIEF NSSR K R M STI V RMPDGRILLFCK G A DSVIYSRLKKEQADMRRETAQH LEMF AVE G L R T LCI AERELSEEEYRE WRREHDLAATALENREEKLEEVADKI E R D LTL L GGT AIE DRL QDG VPDTIALLADAGI KLW V L T G D KVE T A I N I GFSC NLLSVLC C R VSPAQ K AAV VSMV KNGLDVMT LSI G D G A N D VAM IQEADVG V G IAGEE GRQ A VMSS DFAIGQ F RFL Q R LVL V H G R W S YRRLAETISNF F Y K NMIWTWSIF WYQCYCNFDIAYIFEYTYILMF NLFFT SVP VILM GVLD Q D V S DTVSLAVP Q L YRRGIERKEWTQTKFWLYMIDGVYQFIFVVLTPTAAGNGLDVSERTRLGAYIAHPAVI TINGYILINTYRWDWLMLLSIVLSDVFIFFWTGVYTATTYSAGFYQAAPQ
5 | 6k7gA | 0.41 | 0.39 | 11.45 | 3.32 | MUSTER |  | ----------EVRTIFINQP---QLTKFCNNHVSTAK Y N IIT F L PRFLYSQ FRRAA NSFF LFIALL QQI PDVSPTGRYT TLV P LLFILAVAAIKEIIEDIKR H KAD NAV NKKQTQV LRNGAWEIVHWEKVNV G D IVIIKGKEYIPA DTVL L S S S E PQAMC YIE TSNL D G E T N L KIRQGLPAT SDI-KDVDSLMRISGRIEC ESP NRHLYDFVGNIR-----VPLGADQILL R GAQL R N TQWVHGIVVYTGHD T K L M Q N STSPPLKLSNVERITNVQILILFCIL IAMSLVCSVGSAI WNRRHSGKDWYLNLNYGGASN----FGLNFLTFI ILFNNLIP I S LLVTLE VVKFTQAY F I N W DLDMHYEPTDTAAMA R TSNL N E E L G QVKY I F S D K T G T L TCNVMQF KKCTIAGVAY GQNFSDSSL---------------------------LENLQNNHPTAPIICE F LTMMAVC H TAVPE-RERDKII Y QAAS P D E G A L VRA AKQLNFVFTGR T PDSVIIDSL GQEERYEL LNVLEFTSAR K R M S V I V RTPSGKLRL YCK G A D TVIYDRLAETSK-YKEITLKH LEQF ATE G L R T LCFAVAEISESDFQE WRAVYQRASTSVQNRLLKLEESY ELI EKNLQL L G A T AIE D K L QDQVPE TIETLMKADI K I WIL T G D K Q E T A I N I GHSCKLLAV I C C R VSP L Q KSEV V EMV K KQVKVV T L A I G D G A N D V S M IQTA HVG V G I S GNE G L Q AANSS D Y SIA Q FKY LKNL LMIH GAWNYNRVSKCILYCF Y K NIVLYIIEIW FAFVNG F SGQILFERWCIGLYNVMFTAMPPLTLG I FERSCRKENMLKYPEL Y KTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVYTGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAM
6 | 6rohA | 0.41 | 0.39 | 11.48 | 3.61 | HHsearch |  | -----------PRVIHIN DSLANSSFGYSD NHISTTK Y NFAT F L PKFL FQEFSKYA NLFF L CTSAIQQVPHVSPTNRYT T IGTLLVVLIVSAMKECIEDIKRANS DKELN NSTAEIFSEDDFVEKRWIDIRV G D I IRVKSEEPIPA DTIIL S S S E PEG L C YIE T ANL D G E T N L KIKQSRVETAKFID-VKTLKNMNGKV VSEQP NSSLYTYEGTMTLNDRQIPLSPDQMI L R GATL R N TAWIF GLV I FTGHET K LLRNATATPIK R TAVEKIINRQIIALFTVL IVLILISSI G NVIMSTADAKHL-SYLYLEG--TNKAGLFFKDFLTFWILFSNLV P I S LFVTV ELIKYYQAFMIGSDLDLY YEKTDTPTVVR TSSLVE E L G Q I E Y I F S-K T G T L TRN I MEF KSC S IAGHCYIDKIPEDKTATVED--GIEVG-------YRKFDDLKKKLNDPSDEDSPIINDF LTL L ATC H T VIPEFQSDGSIKY QAAS P D E G A L VQGGADLGYKFIIRKPNSVTVLLEGEEKEY Q L LNICEF NST R K R M SAIFRFPDGSI K LFCK G A D TVILERLDDEANQYVEATMRH LEDYASE G L R T LCLAMR DISEGEYEE WNSIYNEAATTLDNRAEKLDEAANLI EKNLILIG A T AIE D K L QDG VPE TIHTLQEAGI K I W V L T G DRQ E T A I N I GMSCRLLSV I C C R VSP L Q K ALV VKMV KRKSSSLLL A I G D G A N D V S M IQAA HVG V G I S GME GMQ AARSADIAVGQ FKFLKKL L L V H GSW S YQRISVAILYSF Y K NTALYMTQF WYVFANAF SGQSIMESWTMSFYNLFFTVWPPFVIGVF D QFV SSRLLERYP Q L Y KLG QKGQFPHSWLVRDFLWKYYKRMYEHVQQQVRQVQRMKKQRGFA FSQAEEG-------GQEK-IVRMYDTTQKRGELQDASA-----------------------
7 | 6rohA | 0.40 | 0.38 | 11.08 | 5.74 | FFAS-3D |  | -----------PRVIHIN DSLANSSFGYSD NHISTTK Y NFAT F L PKFL FQEFSKYA NLFF L CTSAIQQVPHVSPTNRYT T IGTLLVVLIVSAMKECIEDIKRANS DKELN NSTAEIFSHDDFVEKRWIDIRV G D I IRVKSEEPIPA DTIIL S S S E PEG L C YIE T ANL D G E T N L KIKQSRVETAKFIDV-KTLKNMNGKV VSEQP NSSLYTYEGTMTLNDRQIPLSPDQMI L R GATL R N TAWIF GLV I FTGHET K LLRNATATPIK R TAVEKIINRQIIALFTVL IVLILISSI G NVIMSTADAKHLSYL---YLEGTNKAGLFFKDFLTFWILFSNLV P I S LFVTV ELIKYYQAFMIGSDLDLY YEKTDTPTVVR TSSLVE E L G Q I E Y I F S-K T G T L TRN I MEF KSC S IAGHCYIDKIPEDKTATVEDGIEVGY-------------RKFDDLKKKLNDPSPIINDF LTL L ATC H T VIPEFQSDGSIKY QAAS P D E G A L VQGGADLGYKFIIRKPNSVTVLLEGEEKEY Q L LNICEF NST R K R M SAIFRFPDGSI K LFCK G A D TVILERLDDEANQYVEATMRH LEDYASE G L R T LCLAMR DISEGEYEE WNSIYNEAATTLDNRAEKLDEAANLI EKNLILIG A T AIE D K L QDG VPE TIHTLQEAGI K I W V L T G DRQ E T A I N I GMSCRLLSAVICCRVSPLQKALVVKMVKRKSSLLL A I G D G A N D V S M IQAA HVG V G I S GME GMQ AARSADIAVGQ FKFLKKL L L V H GSW S YQRISVAILYSF Y K NTALYMTQF WYVFANAF SGQSIMESWTMSFYNLFFTVWPPFVIGVF D QFV SSRLLERYP Q L Y KLG QKGQFFSVYIFWGWWKYYKRMYEPETYRKVRQVQRMKKQRGFA FSQAEEGGKIVRMYDTTQKR---GKYG-ELQ--DASA------------------------
8 | 7ky5A | 0.23 | 0.21 | 6.61 | 1.70 | EigenThreader |  | LPLPEDMLDEDGLP---------LAVYPRNKI--RTTKYTPLTFFPKNILFQFHNIYFLILLILGAFQIFGVGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNN-----TRTHILSGCRFAKDYWKN V K V G D IVRVHN NDEIPA DMIL L STSDVDGAC Y V E TKNL D G E T N L K V RQSLK----CSKII---KSSRDVESEGPHANLYSYQGNFKWQDTQNGNI--NNLLL R G CTL R N TK-WAMGMVIFTGTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVN-----GVYYKQ------KPRSRDSTNGFVSFWVAVILYLYISVEIIKTAQAIFIYTD----------------VDYPCTPKSWNISDDL G Q I E Y I F S D K T G T-----LEF KKCTI N GVSY GRAYTEALAGLRVDVDNTQFCPEDLT------FVSKEIVEDLKGSSGDQKCCEHFL L A LAHSVLVEPNDPKKLDIKAQ S P D ESA L VSTA RQLGYSFVSK--SGLIVEIQGVQKEFQVLNVLEF NSSR K R M SCIIKIPGEPKICKGADSVIYSRLDRTQNDATL LEKTALH LEEYATE G L R T LCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVI E RELIL L GGT AIE DRL QDG VPDSIALLAEAGI KLW V L T G D KVE T A I N I GFSC NVLKAVLCCRVSQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEG--------RQAVMC----SRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNF--------DLTFYNLAFP VILLAVLD Q D V S DTVSMLVP Q L YRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVT---ENGLGLDHVFYGWTGIWTSSSSSNEFYKFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRP
9 | 6rohA | 0.43 | 0.38 | 11.19 | 5.04 | CNFpred |  | ------------RVIHIN DSLANSSFGYSD NHISTTK Y NFAT F L PKFL FQEFSKYA NLFF L CTSAIQQVPHVSPTNRYT T IGTLLVVLIVSAMKECIEDIKRANS DKELN NSTAEIFSEDDFVEKRWIDIRV G D I IRVKSEEPIPA DTIIL S S S E PEG L C YIE T ANL D G E T N L KIKQSRVETAKF-IDVKTLKNMNGKV VSEQP NSSLYTYEGTMTLNDRQIPLSPDQMI L R GATL R N TAWIF GLV I FTGHET K LLRNATATPIK R TAVEKIINRQIIALFTVL IVLILISSI G NVIMSTADAKHLSYLYL----GTNKAGLFFKDFLTFWILFSNLV P I S LFVTV ELIKYYQAFMIGSDLDLY YEKTDTPTVVR TSSLVE E L G Q I E Y I F SMK T G T L TRN I MEF KSC S IAGHCYIDK---------IPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDF LTL L ATC H T VIPEFQSDGSIKY QAAS P D E G A L VQGGADLGYKFIIRKPNSVTVLLEGEEKEY Q L LNICEF NST R K R M SAIFRFPDGSI K LFCK G A D TVILERLDDEANQYVEATMRH LEDYASE G L R T LCLAMR DISEGEYEE WNSIYNEAATTLDNRAEKLDEAANLI EKNLILIG A T AIE D K L QDG VPE TIHTLQEAGI K I W V L T G DRQ E T A I N I GMSCRLLAV I C C R VSP L Q K ALV VKMV KRKSSSLLL A I G D G A N D V S M IQAA HVG V G I S GME GMQ AARSADIAVGQ FKFLKKL L L V H GSW S YQRISVAILYSF Y K NTALYMTQF WYVFANAF SGQSIMESWTMSFYNLFFTVWPPFVIGVF D QFV SSRLLERYP Q L Y KLG QKGQFFIFWGWIINGFFHSAI-----------------------------------------------------------------------------------
10 | 6k7gA | 0.31 | 0.24 | 7.33 | 1.00 | DEthreader |  | ------------------------------------------------RF-YSQFRRAANSFFLFIALL-----VS-RYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNEIVHWE--KVNV G D IVIIKGKEYIPA DTVL L S S S E PQAMC YIE TSNL D G--ETNLKIRQ-GLPATSDIKDSLIGRIEC--------------------NIRVPLGADQILL R GAQL R N TQWVHGVVYTGHDTKLMQNSTS-PPLKL---SNVERITNVQILILFCILIAMSLVCSVGSAIWNRRSGLNLNYGG--ASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAY-F---I N W DLDMHYEPTDTAAMA R TSNL N E E L G QVKY I F S D K T G T L TCNVMQF KKCTI--AGVAYGQN--FSDSS--L---LEN------------L-QNNH-PT-APIICEFLTMMAVCH-TAVPERERD----KIIYQAAP D E G A L VRA AKQLNFVFTGR T PDSVIIDSL GQEERYEL LNVLEF-TSARKRMSVIVRTPGKLRL YCK G A D T-VIY-DRLAETSKYKETLKH LEQF ATE G L R T LCFAVAIDFQEWRAVYQRAS--T--------SVQNRLLKLEESYEELQLA T AIE D K L QDQVPE TIETLMKADI K I WIL T G D K Q E T A I N I GHSCKLLAV I C C R VSP L Q KSEV V EMV K KQVKVV T L A I G D G A N D V S M IQAHVGVGISGNGLQAANSSDYSIAQ--FKY LKNL LMIH GAWNYNRVSKCILYCF Y K NIVLYIIEIW FAFVNG F SGQILFERWCIGLYNVMFTAMPPLTLG I FERSCRKENMLKYPEL Y KTSQNALAGLETSYWTW---------------------------------L--PVA-----------------------VYKVI-----------------------
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.7284
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 6lcpA | 0.97 | 1.86 | 0.383 | 0.987 | model1_6lcpA.pdb.gz
| 2 | 7ky5A | 0.94 | 2.53 | 0.379 | 0.979 | model1_7ky5A.pdb.gz
| 3 | 6rohA | 0.92 | 2.68 | 0.398 | 0.973 | model1_6rohA.pdb.gz
| 4 | 6lknA | 0.86 | 3.67 | 0.319 | 0.952 | model1_6lknA.pdb.gz
| 5 | 6k7gA | 0.81 | 4.42 | 0.381 | 0.930 | model1_6k7gA.pdb.gz
| 6 | 3kdpA | 0.65 | 5.79 | 0.141 | 0.793 | model1_3kdpA.pdb.gz
| 7 | 6xmpA | 0.64 | 5.77 | 0.139 | 0.802 | model1_6xmpA.pdb.gz
| 8 | 3ixzA | 0.64 | 5.55 | 0.136 | 0.775 | model1_3ixzA.pdb.gz
| 9 | 3ba6A | 0.63 | 6.72 | 0.113 | 0.824 | model1_3ba6A.pdb.gz
| 10 | 6a69A | 0.59 | 6.56 | 0.145 | 0.780 | model1_6a69A.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0003824 | 1.00 | catalytic activity
GO:0043492 | 0.99 | ATPase activity, coupled to movement of substances
GO:0022892 | 0.99 | substrate-specific transporter activity
GO:0004012 | 0.75 | phospholipid-translocating ATPase activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0009987 | 0.87 | cellular process
GO:0016043 | 0.64 | cellular component organization
GO:0006996 | 0.58 | organelle organization

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 0.99 | cell part
GO:0016020 | 0.88 | membrane
GO:0044424 | 0.83 | intracellular part
GO:0005886 | 0.79 | plasma membrane
GO:0043227 | 0.63 | membrane-bounded organelle
GO:0044444 | 0.62 | cytoplasmic part
GO:0043231 | 0.62 | intracellular membrane-bounded organelle
GO:0044425 | 0.55 | membrane part
GO:0016021 | 0.54 | integral component of membrane

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.424 | 3b8cA | 0.580 | 6.39 | 0.113 | 0.754 | 3.6.3.6 | 392
| 2 | 0.060 | 2ckjA | 0.268 | 8.14 | 0.029 | 0.390 | 1.17.1.4 1.17.3.2 | NA
| 3 | 0.060 | 3ixzA | 0.638 | 5.55 | 0.136 | 0.775 | 3.6.3.10 | 392
| 4 | 0.060 | 1llwA | 0.268 | 8.87 | 0.051 | 0.419 | 1.4.7.1 | NA
| 5 | 0.060 | 3hmjA | 0.273 | 9.13 | 0.041 | 0.439 | 2.3.1.86 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
No Binding sites was predicted
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.