D-I-TASSER Q8WTR8-D1

D-I-TASSER results for Q8WTR8-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q8WTR8 (489 residues)
MPVTFALLLLLGQATADPCYDPQGRPQFCLPPVTQLAAVAASCPQACALSPGNHLGARET
CNGSLTLALGGPFLLTSVSLRFCTPGPPALILSAAWASGGPWRLLWHRPAWPGALGGPER
VTFHSTPGPKATVAASHLRVEFGGQAGLAAAGLRGRCQCHGHAARCAARARPPRCHCRHH
TTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCE
RCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGV
TGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLATTPGAYSSDPQCQNYCNMSDTRVHMSL
RRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQRAQPVRRGDQDAWVPRADLTCGC
LRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRLQQEERAGGCRGVRA
PTPSPRPEH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPVTFALLLLLGQATADPCYDPQGRPQFCLPPVTQLAAVAASCPQACALSPGNHLGARETCNGSLTLALGGPFLLTSVSLRFCTPGPPALILSAAWASGGPWRLLWHRPAWPGALGGPERVTFHSTPGPKATVAASHLRVEFGGQAGLAAAGLRGRCQCHGHAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLATTPGAYSSDPQCQNYCNMSDTRVHMSLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQRAQPVRRGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRLQQEERAGGCRGVRAPTPSPRPEH
Prediction	CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCSSSSSSSSSSSSCCCCCSSSSSSSSCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCSSSSCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCSSSSSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCSSCCCCSSSSSCCCCCCCCCCSSSSCCCCSSSSCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
Confidence	974233432247898998889899977578865003122567778887588866676578743799638975899999999827999605787750499863221134468888899875444789875654021234663265310127765656636898773567899825647999708886668887778987667888888752568999988878684213688899976716999997789986699987089987889998875789899987898103799868779997389987789998789999989867888998867689987789988888878887645777667656753120376402478884277776666732677410367733776367655588444599536886168889888648975874167153366456899999998478877788888888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPVTFALLLLLGQATADPCYDPQGRPQFCLPPVTQLAAVAASCPQACALSPGNHLGARETCNGSLTLALGGPFLLTSVSLRFCTPGPPALILSAAWASGGPWRLLWHRPAWPGALGGPERVTFHSTPGPKATVAASHLRVEFGGQAGLAAAGLRGRCQCHGHAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLATTPGAYSSDPQCQNYCNMSDTRVHMSLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQRAQPVRRGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRLQQEERAGGCRGVRAPTPSPRPEH
Prediction	413000000004432202011775302301140100020012122213113434232331230202030534010000001020220300001012244320121222230121424044230420210111000010000000100000030203030111013022574403030331140544340250023300220012213120202011304302001201413133200100103511102101302100001213222245302425021300210202343040303631415304402610112614143033022132122021232134241443053142313223422034112020200213332430120212022124444330342532111225414030230426340000012443353110102441001102650342044014533656166245536555468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCSSSSSSSSSSSSCCCCCSSSSSSSSCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCSSSSCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCSSSSSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCSSCCCCSSSSSCCCCCCCCCCSSSSCCCCSSSSCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MPVTFALLLLLGQATADPCYDPQGRPQFCLPPVTQLAAVAASCPQACALSPGNHLGARETCNGSLTLALGGPFLLTSVSLRFCTPGPPALILSAAWASGGPWRLLWHRPAWPGALGGPERVTFHSTPGPKATVAASHLRVEFGGQAGLAAAGLRGRCQCHGHAARCAARARPPRCHCRHHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLATTPGAYSSDPQCQNYCNMSDTRVHMSLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQRAQPVRRGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRLQQEERAGGCRGVRAPTPSPRPEH

4aqsA

0.21

0.14

4.40

0.83

DEthreader

-------------------GCA----YPATGDLLIRALSVSTCGE-YCIVSHDKKC-NGVENVTIQLDLEA-EFHFTHLIMTFKTFRPAMLIERSSDFGKAWGVYRYDSRYSDPTEGEVIFRALDFIDRIQNLKITNLRIKFVLYAVYDMVVRGNCF-CYGHASECAPVVVHGHCMCRHNTKGLNCELCMDFYHDLPWR-PAEGNSNACKKCNCNEHSSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCEPCTCDPGSENGICDGYTIAGQCRCHVEGE--RCDVCKEGFYDLSA---YGCKSCACN---------------------------P-----------LGTI----------------------------------------------------PGG---------------------------YCYCKRLVTG-------------------QR---

4aqsA

0.13

0.09

3.19

1.03

EigenThreader

LIG----------RAQKTSTCGLHKSRDPYHET--------LNPDSHLIENVVTTLKIWWQSENIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKAWGYRYFAYDCERYSDIEPSTEGPYSPRIQNLLKITNLRIKLHTLEKYYYAVYDMGNCFCYGHASEVEGMVHGHCMCRHNTKLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSSSCHFD-MAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCTCDP--------------------------------------------------AGSENGGICDGYTDFSVGLIAGQCRCKLHVEGERCD----------VCK--------EGFYD---------LSAEDPYGCKSCACNPLGTIPGGNPCDSET------GYCYCKRLVTGQRCDQ----------------------------------------

4plmA

0.47

0.30

8.70

4.97

SPARKS-K

---------------PDPCYDEHGLPRRCIPDFVNSAFVSSTCGKYCVVTEKGDLNNQYPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGKTWVPFQFTDVFSTLDGRPTAHDFDNSPVLQDWVTATDIKVTFSRLHTFGDLQVGGRCKCNGHASRCVRDDDNLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKPISHRKACKECDCHPVGAAGQTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------

4wnxA

0.27

0.18

5.65

1.26

MapAlign

--GRKLRADTMCGQNATELFRQPKCDKCNAAHSHLAHPPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYFAYSNPFPCTGGEVIFRALAKVQEQLKITNLRVRLLKRQAVYDFIVKGSCFCNGHADQCLPVVVHGRCMCKHNTAGSHCQHCAPLYNDRPWEAADTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAVTFCDPSNGDCPCKPGVAGPHCDRCM---------------------------------------------------------------VG-----------YWGF---------------GDYGCRP-----------CDCAGSCD---------------P---LTGDC-----------------------------------

4plmA

0.43

0.29

8.39

0.93

CEthreader

PPSRYCVVTEKGEEQVRSCHLCNASDPKRAHPPSFLTDLNNPHNLTCWQSDSY---VQYPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGKTWVPFQFYSTFSTLDGRPTAHDFDNSPVLQDWVTATDIKVTFSRLHAVSDLQVGGRCKCNGHASRCVDRDDNLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKPISHRKACKECDCHPVGAAGQTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------

4plmA

0.47

0.30

8.64

2.38

MUSTER

---------------PDPCYDEHGLPRRCIPDFVNSAFVSSTCGKYCVVTEKGDSYVQYPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGKTWVPFQFYSTFSTLDGRPTAHDFDNSPVLQDWVTATDIKVTFSRLHAVSDLQVGGRCKCNGHASRCVRDDDNLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKPISHRKACKECDCHPVGAAGQTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------

4plmA

0.47

0.30

8.75

4.60

HHsearch

---------------PDPCYDEHGLPRRCIPDFVNSAFVSSTCGKYCVVTEKGDLNDSYPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGKTWVPFQFYSAFSTLDGRPTAHDFDNSPVLQDWVTATDIKVTFSRLHAVSDLQVGGRCKCNGHASRCVRDRDNLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKPISHRKACKECDCHPVGAAGQTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------

7ndgA

0.47

0.30

8.63

2.76

FFAS-3D

----------------DPCSDENGHPRRCIPDFVNAAFVSSTCGRSCHLCNASDPKKAHPPNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCTLDGRPSAHDFDNSPVLQDWVTATDIRVADSYFYAVSDLQVGGRCKCNGHAARCVDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------

4plmA

0.40

0.25

7.36

1.38

EigenThreader

--------------PDPCYDEHGLPRRCIPDFASDPK----RAHPPSFLTDLNNPHNLTCWQSTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGKTWVPFQFYSTQTDVRPLSGFSTLDGRPVLQDWVTATDIKVFSRLFYAVS-DLQVGGRCKCNGHA--SRRDDNLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKPISHRKACKECDCHPVGAAGQTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKP--------------------------------------------------------------------------------------------------------------------------------------------------------------------

4oveA

0.51

0.28

8.05

7.19

CNFpred

------------------------------------------------------------HNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLYAVSDLQVGGRCKCNGHAARCVRDRDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.5047

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	4plmA	0.58	2.74	0.440	0.628	model1_4plmA.pdb.gz
2	4wnxA	0.55	3.27	0.276	0.616	model1_4wnxA.pdb.gz
3	4aqsA	0.52	4.21	0.251	0.622	model1_4aqsA.pdb.gz
4	4aqtA	0.46	2.99	0.285	0.507	model1_4aqtA.pdb.gz
5	2y38A	0.46	3.01	0.284	0.509	model1_2y38A.pdb.gz
6	3zygA2	0.23	2.77	0.149	0.247	model1_3zygA2.pdb.gz
7	3zyjB2	0.22	3.04	0.148	0.247	model1_3zyjB2.pdb.gz
8	3p1vA	0.19	6.48	0.026	0.294	model1_3p1vA.pdb.gz
9	1npeB1	0.18	3.21	0.262	0.209	model1_1npeB1.pdb.gz
10	4hjjH3	0.15	4.64	0.042	0.192	model1_4hjjH3.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0005198	0.54	structural molecule activity
GO:0097367	0.52	carbohydrate derivative binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0044699	0.98	single-organism process
GO:0009987	0.94	cellular process
GO:0044763	0.93	single-organism cellular process
GO:0065007	0.89	biological regulation
GO:0050789	0.87	regulation of biological process
GO:0050794	0.86	regulation of cellular process
GO:0032502	0.84	developmental process
GO:0044767	0.82	single-organism developmental process
GO:0016043	0.77	cellular component organization
GO:0006928	0.76	movement of cell or subcellular component
GO:0009653	0.74	anatomical structure morphogenesis
GO:0007411	0.69	axon guidance
GO:0048856	0.67	anatomical structure development
GO:0048518	0.65	positive regulation of biological process
GO:0050793	0.64	regulation of developmental process
GO:0051128	0.63	regulation of cellular component organization
GO:0030030	0.63	cell projection organization
GO:0040012	0.62	regulation of locomotion
GO:2000026	0.61	regulation of multicellular organismal development
GO:0048522	0.61	positive regulation of cellular process
GO:0045595	0.61	regulation of cell differentiation
GO:0031344	0.61	regulation of cell projection organization
GO:0022603	0.61	regulation of anatomical structure morphogenesis
GO:0007165	0.61	signal transduction
GO:0051960	0.60	regulation of nervous system development
GO:0032501	0.60	multicellular organismal process
GO:0022604	0.60	regulation of cell morphogenesis
GO:0051270	0.59	regulation of cellular component movement
GO:0010975	0.59	regulation of neuron projection development
GO:2000145	0.58	regulation of cell motility
GO:0010769	0.58	regulation of cell morphogenesis involved in differentiation
GO:0050770	0.57	regulation of axonogenesis
GO:0048870	0.57	cell motility
GO:0048638	0.57	regulation of developmental growth
GO:0030198	0.57	extracellular matrix organization
GO:0001558	0.57	regulation of cell growth
GO:0048869	0.56	cellular developmental process
GO:0030516	0.56	regulation of axon extension
GO:0016477	0.56	cell migration
GO:0040017	0.55	positive regulation of locomotion
GO:0022607	0.55	cellular component assembly
GO:0048519	0.54	negative regulation of biological process
GO:0030334	0.54	regulation of cell migration
GO:0051094	0.52	positive regulation of developmental process
GO:0048598	0.52	embryonic morphogenesis
GO:0045597	0.52	positive regulation of cell differentiation
GO:0007155	0.52	cell adhesion
GO:0098602	0.51	single organism cell adhesion
GO:0051272	0.51	positive regulation of cellular component movement
GO:0050769	0.51	positive regulation of neurogenesis
GO:0035556	0.51	intracellular signal transduction
GO:0031346	0.51	positive regulation of cell projection organization
GO:2000147	0.50	positive regulation of cell motility
GO:0051241	0.50	negative regulation of multicellular organismal process
GO:0051093	0.50	negative regulation of developmental process
GO:0048639	0.50	positive regulation of developmental growth
GO:0048523	0.50	negative regulation of cellular process
GO:0035239	0.50	tube morphogenesis
GO:0010976	0.50	positive regulation of neuron projection development
GO:0007264	0.50	small GTPase mediated signal transduction
GO:0002009	0.50	morphogenesis of an epithelium

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	0.90	cell part
GO:0044421	0.88	extracellular region part
GO:0044420	0.76	extracellular matrix component
GO:0005576	0.74	extracellular region
GO:0005604	0.72	basement membrane
GO:0016020	0.69	membrane
GO:0031012	0.63	extracellular matrix
GO:0043226	0.58	organelle
GO:0044424	0.56	intracellular part
GO:0005578	0.55	proteinaceous extracellular matrix
GO:0043227	0.52	membrane-bounded organelle

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1kitA	0.313	6.98	0.029	0.499	3.2.1.18	NA
2	0.060	1mc0A	0.234	6.50	0.029	0.350	3.1.4.17	NA
3	0.060	3h09B	0.319	7.60	0.045	0.542	3.4.21.72	NA
4	0.060	1ug9A	0.296	7.81	0.038	0.509	3.2.1.70	NA
5	0.060	2v5yA	0.305	7.13	0.032	0.481	3.1.3.48	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	3cmvD	0.295	7.63	0.026	0.497	0.17	ANP	complex1.pdb.gz	247,248,255,261
2	0.01	1kv3A	0.256	7.38	0.035	0.417	0.25	GDP	complex2.pdb.gz	256,275,276,277,278
3	0.01	2xt6A	0.338	7.68	0.055	0.575	0.20	TPP	complex3.pdb.gz	192,193,194,224,249
4	0.01	3cmvG	0.275	7.50	0.038	0.452	0.12	ANP	complex4.pdb.gz	224,225,226,227,228,229
5	0.01	3k71E	0.229	8.01	0.027	0.407	0.35	UUU	complex5.pdb.gz	213,228,237
6	0.01	1xmvA	0.196	6.67	0.057	0.305	0.15	ADP	complex6.pdb.gz	187,188,189,190
7	0.01	2y0pD	0.246	6.85	0.019	0.387	0.14	ACO	complex7.pdb.gz	178,192,211
8	0.01	1y4sA	0.230	7.57	0.027	0.382	0.13	ADP	complex8.pdb.gz	232,237,248
9	0.01	3cmvE	0.277	8.03	0.038	0.499	0.26	ANP	complex9.pdb.gz	247,255,261
10	0.01	2y0pA	0.280	7.28	0.030	0.460	0.12	ACO	complex10.pdb.gz	179,181,183

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.