D-I-TASSER Q96L12-D1

D-I-TASSER results for Q96L12-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q96L12 (384 residues)
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHK
EKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQK
NLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDL
SYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQ
SDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAI
GLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEE
EELLSGKINRHEHYFNQFHRRNEL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL
Prediction	CCHHHHHHHHHHHHCCCCCCSSSSSSCCCCCCCCCCSSSCCCCCCCCSSSSSCCCCCCCCCCCCCSSSCCCCHHHHHHCCCCCCCCCCCCSSSSSSSSSCCCCCCCCSSSSSSCCCCCHHHCCCCCCSSSSSCCCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCSSSSSSCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSCCCCCSSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
Confidence	933678786775322567625577733896412364256577787865998536456886666416755542122333037887689985799999871368642433899755989966657999548995684579998357898740797666678988888998624899984998399999999975065667888999888999888888899887896778777999777899878877899888998899767898888866788877787899998787882337873189999886269815767997299999999999776653578998765551555543113443344456420124566777751479
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL
Prediction	222000000000002014040102030643740663024053673414021320423432643200202452210010350550437632000001042445230000000002661437504661301000000311463420010021535515436515166362110000004443201020244315535145516125355366274374165666641741665135672642741567455716443374172445142663354614364174262362541351540000000010235300000000043362045007511443452054256454565464465666553465445226520530375368
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCHHHHHHHHHHHHCCCCCCSSSSSSCCCCCCCCCCSSSCCCCCCCCSSSSSCCCCCCCCCCCCCSSSCCCCHHHHHHCCCCCCCCCCCCSSSSSSSSSCCCCCCCCSSSSSSCCCCCHHHCCCCCCSSSSSCCCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCSSSSSSCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSCCCCCSSSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL

6enyG

0.54

0.40

11.64

1.17

DEthreader

---------------E--PAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLK-----------------------WDE--------------------------TWIHPE--------------------PEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.52

0.48

13.79

6.53

SPARKS-K

-----------------EPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLKKIKDDASKEDWDDPTDSKPEDWDEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.49

0.45

12.94

1.79

MapAlign

------------------PAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFL-KKIKDPDASKPEDWDEAKIDDPTDPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYWKPRQIDNDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEE----EEAEDK---------

6enyG

0.51

0.47

13.65

1.34

CEthreader

-----------------EPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLKKIKDPDASKPEDWDEATDSKPEDWDKHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.52

0.48

13.79

4.02

MUSTER

-----------------EPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDF--LKKIKDPDKPEDWDEPTDSKPEDWDEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.52

0.47

13.71

6.07

HHsearch

-----------------EPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFL--KKIKDDASKEDWDE-APSKPEDWDKHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.50

0.46

13.37

3.39

FFAS-3D

------------------PAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLKKIKDPDASKPEDWDDPTDSKPEDWPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWQIDNDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.41

0.36

10.67

2.42

EigenThreader

------------------------EPAFLDGDGWTSRWESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESEDDWDFLKKIKDPD--ASKPE---DWDEAKIDDPTDSKPEDWDKPEHPDAKKPEDWDEWEPPNPEYKGEWKPRQIDNDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

6enyG

0.52

0.47

13.71

6.10

CNFpred

-----------------EPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFL--KKIKDPSKPEDWDE-TDSKPEDWDKPIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKE------------

3o0vA

0.59

0.39

11.06

1.00

DEthreader

------------G-SMD-PAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDLEKDKGLQTSQDARFYALSAKFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPSGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRSKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDF------------------------------------------------------------------------------------PDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQD-E----------------------------------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.7349

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	6enyG	0.88	1.58	0.501	0.919	model1_6enyG.pdb.gz
2	5hcfA	0.65	1.43	0.390	0.674	model1_5hcfA.pdb.gz
3	3o0vA	0.65	0.70	0.586	0.654	model1_3o0vA.pdb.gz
4	5hcaC	0.62	1.64	0.410	0.641	model1_5hcaC.pdb.gz
5	1jhnA	0.59	4.08	0.263	0.703	model1_1jhnA.pdb.gz
6	1wd4A	0.50	5.01	0.059	0.672	model1_1wd4A.pdb.gz
7	7by5A	0.49	4.67	0.090	0.630	model1_7by5A.pdb.gz
8	1f31A	0.49	4.12	0.078	0.604	model1_1f31A.pdb.gz
9	3btaA	0.48	4.32	0.069	0.609	model1_3btaA.pdb.gz
10	3ffzA	0.48	4.32	0.073	0.607	model1_3ffzA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0043167	0.82	ion binding
GO:0005509	0.81	calcium ion binding
GO:1901363	0.50	heterocyclic compound binding
GO:0097159	0.50	organic cyclic compound binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0009987	0.88	cellular process
GO:0065007	0.85	biological regulation
GO:0044699	0.85	single-organism process
GO:0065008	0.77	regulation of biological quality
GO:0044763	0.77	single-organism cellular process
GO:0050789	0.75	regulation of biological process
GO:0050794	0.73	regulation of cellular process
GO:0050896	0.69	response to stimulus
GO:0050821	0.66	protein stabilization
GO:0051179	0.65	localization
GO:0006950	0.64	response to stress
GO:0006810	0.63	transport
GO:0051716	0.62	cellular response to stimulus
GO:0044767	0.62	single-organism developmental process
GO:0006457	0.62	protein folding
GO:0016192	0.61	vesicle-mediated transport
GO:0016043	0.61	cellular component organization
GO:0051049	0.60	regulation of transport
GO:0033554	0.60	cellular response to stress
GO:0019222	0.60	regulation of metabolic process
GO:0006897	0.60	endocytosis
GO:0060255	0.59	regulation of macromolecule metabolic process
GO:0080090	0.58	regulation of primary metabolic process
GO:0051649	0.58	establishment of localization in cell
GO:0048523	0.58	negative regulation of cellular process
GO:0031323	0.58	regulation of cellular metabolic process
GO:0006898	0.58	receptor-mediated endocytosis
GO:0031324	0.57	negative regulation of cellular metabolic process
GO:0022607	0.57	cellular component assembly
GO:0010605	0.57	negative regulation of macromolecule metabolic process
GO:0008152	0.57	metabolic process
GO:0048869	0.56	cellular developmental process
GO:0048583	0.56	regulation of response to stimulus
GO:0048518	0.56	positive regulation of biological process
GO:0032268	0.56	regulation of cellular protein metabolic process
GO:0022414	0.56	reproductive process
GO:0015031	0.56	protein transport
GO:0010468	0.56	regulation of gene expression
GO:2000113	0.55	negative regulation of cellular macromolecule biosynthetic process
GO:0051172	0.55	negative regulation of nitrogen compound metabolic process
GO:0048584	0.55	positive regulation of response to stimulus
GO:0048522	0.55	positive regulation of cellular process
GO:0042221	0.55	response to chemical
GO:0032269	0.55	negative regulation of cellular protein metabolic process
GO:0010629	0.55	negative regulation of gene expression
GO:0006461	0.55	protein complex assembly
GO:0002682	0.55	regulation of immune system process
GO:1901700	0.54	response to oxygen-containing compound
GO:0071704	0.54	organic substance metabolic process
GO:0044702	0.54	single organism reproductive process
GO:0031325	0.54	positive regulation of cellular metabolic process
GO:0010604	0.54	positive regulation of macromolecule metabolic process
GO:0010033	0.54	response to organic substance
GO:0009966	0.54	regulation of signal transduction
GO:0007568	0.54	aging
GO:0002684	0.54	positive regulation of immune system process
GO:2000510	0.53	positive regulation of dendritic cell chemotaxis
GO:1900026	0.53	positive regulation of substrate adhesion-dependent cell spreading
GO:0090398	0.53	cellular senescence
GO:0061077	0.53	chaperone-mediated protein folding
GO:0050766	0.53	positive regulation of phagocytosis
GO:0048609	0.53	multicellular organismal reproductive process
GO:0048387	0.53	negative regulation of retinoic acid receptor signaling pathway
GO:0045787	0.53	positive regulation of cell cycle
GO:0045740	0.53	positive regulation of DNA replication
GO:0045665	0.53	negative regulation of neuron differentiation
GO:0034504	0.53	protein localization to nucleus
GO:0033144	0.53	negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0030154	0.53	cell differentiation
GO:0017148	0.53	negative regulation of translation
GO:0010038	0.53	response to metal ion
GO:0008284	0.53	positive regulation of cell proliferation
GO:0007050	0.53	cell cycle arrest
GO:0006996	0.53	organelle organization
GO:0006611	0.53	protein export from nucleus
GO:0002502	0.53	peptide antigen assembly with MHC class I protein complex
GO:0000122	0.53	negative regulation of transcription from RNA polymerase II promoter
GO:2000241	0.52	regulation of reproductive process
GO:1901654	0.52	response to ketone
GO:0070887	0.52	cellular response to chemical stimulus
GO:0033993	0.52	response to lipid
GO:0033043	0.52	regulation of organelle organization
GO:0030036	0.52	actin cytoskeleton organization
GO:0014070	0.52	response to organic cyclic compound
GO:0071285	0.51	cellular response to lithium ion
GO:0055007	0.51	cardiac muscle cell differentiation
GO:0044238	0.51	primary metabolic process
GO:0043170	0.51	macromolecule metabolic process
GO:0042493	0.51	response to drug
GO:0040020	0.51	regulation of meiotic nuclear division
GO:0033574	0.51	response to testosterone
GO:0032355	0.51	response to estradiol
GO:0030866	0.51	cortical actin cytoskeleton organization
GO:0010628	0.51	positive regulation of gene expression
GO:0007283	0.51	spermatogenesis

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044424	1.00	intracellular part
GO:0044444	0.98	cytoplasmic part
GO:0044446	0.90	intracellular organelle part
GO:0044432	0.85	endoplasmic reticulum part
GO:0016020	0.85	membrane
GO:0044425	0.79	membrane part
GO:0005789	0.63	endoplasmic reticulum membrane
GO:0043226	0.61	organelle
GO:0043229	0.56	intracellular organelle
GO:0043227	0.55	membrane-bounded organelle
GO:0043231	0.50	intracellular membrane-bounded organelle

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1sliA	0.382	4.84	0.082	0.505	4.2.2.15 3.2.1.18	NA
2	0.060	2np0A	0.488	4.16	0.086	0.607	3.4.24.69	NA
3	0.060	2agsA	0.417	4.29	0.066	0.534	3.2.1.18	NA
4	0.060	2rfwA	0.451	4.14	0.061	0.552	3.2.1.91	NA
5	0.060	1yxwA	0.478	4.32	0.089	0.602	3.4.24.68	50

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Click to view	Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
	1	0.30	3o0wA	0.642	0.52	0.593	0.646	1.59	UUU	complex1.pdb.gz	74,105,106,107,109,111,124,128,131,135,137,145,303,304,305

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

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References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.