D-I-TASSER Q9BQG0-D5

D-I-TASSER results for Q9BQG0-D5

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q9BQG0 (649 residues)
TAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIR
KSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRA
LQLILDVLNPETSEDQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRS
LRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPT
ALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYS
TALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLS
MREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHE
KLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPS
ATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAK
VPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQK
ALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| TAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP
Prediction	CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Confidence	7899999999999999986334068999999999999999837974799999999999999862222222202565567625799999999997177379999999999999986189999999987244310345778887655567899999999848996058999999999999986224662578999999999999874033578875312899999999999999843664789999999999999984244322221013343124542113555333221118999999999999999616899987999999997177888899999997322204789999999999863133434432158999999999999999986321011246789999999999999741124553200021122212233322577555520134323333024788998788888889888889998888888999999898899998899988999999999999999999999999999999999999999999999999999999999999999988889999999999999998888999999999999999988777888889998888899998787889999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| TAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP
Prediction	6751350053015105515554563223000000000000001435201400420340054136555545555555653240100000000000134230013003200410053023600340043032654444444334341312002001200441151000020030003002301546445523400420140034201403611554643263025003400520344443411310110000001002232443434434444444444444444463233130420150035004400443625031400340032012002300320042045443332100111121032342443344740350054015302510431354445344530340040022004114345342514424622553454355355264444035203411633545426565565554565565555555565555565555555566555566665256565655566555565556665366566655565465764655466465536456566516646655553654565554555456655556416544454545354555545445545545654666758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP

4xriA

0.06

2.51

1.05

EigenThreader

ASEGHQKQASLTAIGFICETQDTDLRNSLVSNAILTAVVQGARKNNEVRFAAITALGDSEFVGNNFKHCEATQAQDSRIQQGAFGCLNRIMALYYEHMRYYMEKAFGLTILGMKSDDEDVAKLAVEFWSTVCEEEIAIEDDNAQARVATNEVVPVLLQLLTKQDAAYQCLQLYAQQFVEHNLRHADWHFRDAAVSAFGAI---------MDGPEEKVLEPIVKTGMQPLIAMMEDESIQVRDSTAYALGRITEACSEAI------------------------------DPNTHLEPLIRSLFNGLMNS------PKMAASCCWALMNIAERFVTNLLTVTAPMNGD----STVRTAAYEVLSVFVQNAANDSLSAVASLSTVILQRLEETLPLQQQVDKLILEDMQTSLCTVLQATVQRLDKEIAPQGDRIMQVLLQILSTCGGKSSVPEGVFAAISALANAMEEEFAKYMEAFAPFLYNALGNQEEPSLCSMAIGLVSDVTRSLGERSQPYCDNFMNYLLGNLRSTTLANQFKPAILQCFGDIASAIGGHFETYLTIVAQVLQQAATITAGPDGSYEMIDYVISLREGIMDAWGGIIGAMKTSNKTNVLQPYVESIFALLNSIANDPNRASMGVIGDLADAYPNGQL

4fgvA

0.11

0.08

3.08

1.03

FFAS-3D

---VVDMEQIMTEKLARQVDGSEWSWHNCNVLCWAIGSISMAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVAKAHWKFLKTVVNKLFEFMHESHEGVQDMACDTFIKIAKQCRRHFIEEIIRNI------GKITCDLTPQQVHTFYEACGYMVSAQGNRNQQERLLAELMAIIKAATMNPGILHEPDTIKIIGNIMKTNVSACSSIGPYFFPQIGRLYNDMLQMYAAATKMPKVRGLRTIKKEILKLVETFVEKAEDLQAVRSQ----------------------MIPGLLDSVLVDYNRNVPGARDAEVLKAMTVIITRLQGLMEDQVPAIMENVAEYPEHRVEFFNLLRAINLYCFPALLKLDNRQFKFVTAGLNMCLELINNIAEKTDVQTCNAFFNQFRILQDVFFVLTDTDHKAGFKTQSMLLMRLFYFVHPDQAQPGTGNREFLANFVGTLLQNAFANLTPLQITTFVELNTQYDKFRVVLRDFLISLRE--------FAGDN------------AELYQVEKEQQEREAR------------------------------AADLERRSKVGGL-LKPSE----------LEDEEL------------------------------------------

4xriA

0.09

0.05

2.00

1.29

CNFpred

QETRTRVKQLALETLAS-----NSKAGQAAAQVIAAIAAIELPR--QWPELMHALVRNASEGGQ----------------HQKQASLTAIGFICETQDTDLRNSLVG--------HSNAILTAVVQGARKE----EPNNEVRFAAITALGDSLEFVGNNFKHEGERNYIMQVVCEATQAQ--------DSRIQQGAFGCLNRIMALYYEH------MRYYMEKALFGLTILGMKSDDEDVAKLAVEFWSTVCEEEIAIEDDNAQVESSEQMRPF---------------NFARVATNEVVPVLLQLLTK-DEYNISRAAYQCLQLYAQAVGTIIPPVIQFVEH-WHFRDAAVSAFGAIMDG------PEEKVLEPIVKTGMQPLIAMMEDE-------SIQVRDSTAYALGRITEACSEA---DPNTHLEPLIRSLFNGLMNSPKMA--ASCCWALMNIAERFA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

6xteA

0.07

2.88

1.08

MapAlign

-YENIPGQSKI-TFLLQAIRNTAEEARQMAAVLLRRLLSSVYPALPSDVQTAIKSELLMIIQKKVCDIAAELARNLIDEDGNNPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGDVIKRMLVQCMQDQPSIRTLSARATAAGFDSVLKSLVEIADTVPK--YLRPHLEATLQLSLKLC--GDTSLNNMQRQLALEVIVTLSETAAAMLRKH---TNIVAQTIPQMLAMMVDLEDFDNAVAGESALDRMACLGGKLVLPMIKEHIMQMLDWKYRHAGLMALSAIGEGCQMEGILNEIVNFVLLFLQPRVRYAACNAVGQMATDFAPFQEKVIAALLQTMEGNQRVQAHAAAALINFTED-----CPK-SLLIPYLDNLVKHLHSIMVLKLQELIQKGTLVLEQVVTSIASVADTAEEK-FVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKF---MQDASDVMQLLLKTQTDFPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAI-

6xteA

0.08

3.02

0.59

CEthreader

MVDLEDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGI-----------LNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGN-QRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLIPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATE

1qgkA

0.08

0.07

2.89

0.98

EigenThreader

ELITILEKT---VLELEAAQKFLERAAVENLPTFLVELSRVLASQVARVAAGLQIKNSLT-------SKDTLGTETYRPSSASQCVAGIACAEIPVNQWSTLEAIGYICQDILQDKSNEILTAIIQGMRKEEPS----NNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEAT-----QCPDTRVRVAALQNLVKIMSLYY---------QYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQ------------GRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDLLATCCEDDIVPHVLPFIKEHI-----KNPDWRYRDAAVMAFGCILEG---PEPSQLKPLVIQAMPTLIELM------KDPS----VVVRDTAAWTVGRICELLPEAAYLAPLLQCLIEGL---------SAEPRVASNVCWAFSSLAEAAYEAADVAD---DQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEY

6xjpC

0.11

0.08

2.80

1.02

FFAS-3D

---VIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVAKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFIQTIIRDI------QKTTADLQPQQVHTFYKACGIIISEERSVAERNRLLSDLMTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGAD---FYPQLGHIYYNMLQLATKTPKVRGLRTIKKEILKLVETYISKARNLDD--------------------------VVKVLVEPLLNAVLEDYMNNVPDARTTVVEKVGHMIPQGVILILQSVFECTTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVNGLQIALDLVKNIERMGNVPFANEFHKNFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLKQCKDLVVFKGTLRDFLVQIKE--------VGGDPTD-------------------------------------------------------------------------------------------------------------------------------------

3gjxA

0.08

0.07

2.85

0.91

SPARKS-K

RNQCEGIKKYVVGLIIKTSSDKEKVYIGKLNMILVQILKQEWPSESLCQNNMVILKLLSEEVFDFQVKAKHLKDSMCNE---FSQIFQLCQFVMENSNAPLVHATLETLLRFLNWIPTKLISTLIYKFLNVP-----------MFRNVSLKCLTEIAGVSVSEEQFETLFTLTMMQLKQMLPLNTNDDEQNFIQNLSLFLCTFLKEHGQLLEKRLNLREALMEALHYMLLVS-EVEETEIFKICLEYWNHLAAELYRESPFSTS------------ASPLLSGSQHFDIPRRQLYLTVLSKVRLLMVSRM-AKPERETLVYLTHLDYVDTEIIMTKKLQNQVTEWSNLNTLCWAIGSI------SGAMHEEDEKRFLVTVIKDLLGLCEQKRGK--DNKAIIASNIMYIVGQYPRFLRAH-----WKFLKTVVNKLFEFM-HETHDGVQDMACDTFIKIAQKCGEVMPNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAR

5vchA

0.10

0.06

2.22

1.29

CNFpred

RSLSAQALSYVSSLIEEINPQYAAKFASLIPSVVQVLDATIREDTTNTKLIFNCLNDFLLLDSQLT--------------NTIADLVKLALQIAVNVDEDIRVFAVQFVTSALV-LGPEITLAALKVASEEIDVEDELTNE--TPALTALRLISNASGELSPSQVGVPIIEHLPTMLSSS---------NPFERRSILLAISVLVTG---------SPDYTLSQFDKIIPATVTGLKDSEAVVQLAALKCIVQLSTNLQ--------------------------DEVARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEF-IKYLDPLMNKLFQMLETQQSPRAAIVSAIGSCAFAAGS-------GFVPYFKTSVQYLQQFIQNVSQILSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYEAI--------KTDSARLRESGYAFIANMA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4fgvA

0.08

0.06

2.41

1.00

DEthreader

-------------------------------FINEIVSACHSSLSVCE----------------------------------F--CQEILNSATPLIKATLETLLFCIPLGYIFETPL-IDTLRTRFLEV-----------PE-FRNVTLQCLTEIGGLQTDLIKMFTVLTTISNIIPMLTYPNSNSRDQEFIQNLALFLT-SFF-TMHLPLIENLPNRDFLTHGHFYLIRIS-Q-IDD-REIFKICLDYWLKLVQE-LYEEMQSLPLNDMSSMGLGMALLEHY-PLRKHKYKEVLSNLRVVMIEKM-------SVQLYKTIRECLVYLTHDDMEQIMTKLAQVWSNCNVLCWAIGSIS--------M-A-MNEETEKRFLVTVIKDLLGLTEMKRGDNKAVVASNIMYIVGQY--P---RFLKAHWKFLKTVVNKLFEFMH-ESHEGVQDMACDTFIKIAKCRFFIEEIIRNIG-K----ITCDLTPQQVHTFYEACGELMAIPNAAWDEIIAAPGIL------DTIKIIGNIMKTNVQIGLYNDMLQMYAA--------------RIKKEILKVEFVLQAVRSQMIPGLLDSV-------------------I-RLQGLMEDQVPMAINLYCFPAL-----------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.3856

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	4fgvA	0.69	5.08	0.072	0.855	model1_4fgvA.pdb.gz
2	3icqT	0.65	5.51	0.069	0.834	model1_3icqT.pdb.gz
3	2x1gF	0.61	6.00	0.060	0.832	model1_2x1gF.pdb.gz
4	3a6pA	0.61	5.99	0.060	0.820	model1_3a6pA.pdb.gz
5	6q82A	0.60	6.34	0.062	0.832	model1_6q82A.pdb.gz
6	6xjpC	0.60	5.97	0.079	0.792	model1_6xjpC.pdb.gz
7	3gjxA	0.60	5.96	0.066	0.790	model1_3gjxA.pdb.gz
8	5dlqB	0.58	5.78	0.080	0.775	model1_5dlqB.pdb.gz
9	4c0oA	0.58	5.99	0.079	0.777	model1_4c0oA.pdb.gz
10	6n1zA	0.57	6.33	0.056	0.789	model1_6n1zA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0003676	0.86	nucleic acid binding
GO:0003677	0.83	DNA binding
GO:0044212	0.80	transcription regulatory region DNA binding
GO:0000989	0.80	transcription factor activity, transcription factor binding
GO:0003714	0.79	transcription corepressor activity
GO:0001047	0.79	core promoter binding
GO:0003723	0.62	RNA binding
GO:0044822	0.58	poly(A) RNA binding
GO:0008134	0.57	transcription factor binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0065007	0.87	biological regulation
GO:0044699	0.87	single-organism process
GO:0050794	0.86	regulation of cellular process
GO:0051234	0.84	establishment of localization
GO:0006810	0.83	transport
GO:0080090	0.82	regulation of primary metabolic process
GO:0060255	0.82	regulation of macromolecule metabolic process
GO:0031323	0.82	regulation of cellular metabolic process
GO:0051649	0.81	establishment of localization in cell
GO:0051641	0.81	cellular localization
GO:0048523	0.81	negative regulation of cellular process
GO:0006355	0.81	regulation of transcription, DNA-templated
GO:0046907	0.80	intracellular transport
GO:0045892	0.80	negative regulation of transcription, DNA-templated
GO:0032501	0.80	multicellular organismal process
GO:0044707	0.79	single-multicellular organism process
GO:0006913	0.79	nucleocytoplasmic transport
GO:0032922	0.77	circadian regulation of gene expression
GO:0009987	0.73	cellular process
GO:0044763	0.66	single-organism cellular process
GO:0050896	0.61	response to stimulus
GO:0051726	0.60	regulation of cell cycle
GO:0010564	0.59	regulation of cell cycle process
GO:0048518	0.58	positive regulation of biological process
GO:0051716	0.57	cellular response to stimulus
GO:0048869	0.57	cellular developmental process
GO:0048522	0.57	positive regulation of cellular process
GO:0007165	0.57	signal transduction
GO:0006950	0.57	response to stress
GO:0042981	0.56	regulation of apoptotic process
GO:0035556	0.56	intracellular signal transduction
GO:0033554	0.56	cellular response to stress
GO:0030154	0.56	cell differentiation
GO:0007154	0.56	cell communication
GO:2000210	0.55	positive regulation of anoikis
GO:0072332	0.55	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0071158	0.55	positive regulation of cell cycle arrest
GO:0042149	0.55	cellular response to glucose starvation
GO:0001649	0.55	osteoblast differentiation

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	0.99	cell part
GO:0044424	0.98	intracellular part
GO:0044446	0.93	intracellular organelle part
GO:0043226	0.93	organelle
GO:0043229	0.92	intracellular organelle
GO:0043231	0.91	intracellular membrane-bounded organelle
GO:0005634	0.90	nucleus
GO:0044428	0.89	nuclear part
GO:0005737	0.89	cytoplasm
GO:0032991	0.88	macromolecular complex
GO:0043234	0.87	protein complex
GO:0043232	0.85	intracellular non-membrane-bounded organelle
GO:0005730	0.83	nucleolus
GO:0042564	0.79	NLS-dependent protein nuclear import complex
GO:0016020	0.63	membrane

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1wz2A	0.312	8.30	0.035	0.516	6.1.1.4	NA
2	0.060	2gv9B	0.349	8.02	0.029	0.567	2.7.7.7	436,454,459
3	0.060	3h09B	0.314	7.75	0.034	0.491	3.4.21.72	442,474,493
4	0.060	2vuaA	0.161	7.30	0.032	0.245	3.4.24.69	461,463
5	0.060	2uv8G	0.353	7.88	0.052	0.564	2.3.1.86	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	2bptA	0.500	6.94	0.060	0.724	0.71	III	complex1.pdb.gz	426,429,430,433,434,465
2	0.01	2gl7D	0.404	6.12	0.084	0.553	0.58	III	complex2.pdb.gz	429,432,436
3	0.01	1o6pA	0.390	6.57	0.071	0.556	0.74	III	complex3.pdb.gz	378,381,382,428,431,432
4	0.01	2gl7A	0.395	6.02	0.075	0.539	0.40	III	complex4.pdb.gz	426,432,436,439,459,463

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.