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# D-I-TASSER results for Q9C0A0-D1

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q9C0A0 (1308 residues) MGSVTGAVLKTLLLLSTQNWNRVEAGNSYDCDDPLVSALPQASFSSSSELSSSHGPGFAR LNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWNW KQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYR SEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRAR LFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGE FNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNV SFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGIL LFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLL GPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFS DLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHR GNTSGFYYIDSDGSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRNTNPENPYAGFFEYV ASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDGTPLSWWVGRTNETQTYWGGSSPDLQ KCTCGLEGNCIDSQYYCNCDADRNEWTNDTGLLAYKEHLPVTKIVITDTGRLHSEAAYKL GPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIADFI RIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQ PAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRG HCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLL SKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRY KLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKS LVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGHVTES SCMAQPGTDATSRERTHSFADHSGTIDDREPLANAIKSDSAVIGGLIAVVIFILLCITAI AVRIYQQKRLYKRSEAKRSENVDSAEAVLKSELNIQNAVNENQKEYFF

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300
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Prediction
CCCCCCCSSSSSSSSSCCSSSSSSCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCSSSSCCCCSSSSSSSSCCCCCCCCSSSSSSSSSSCCCCCCSSSSCCCCCCSSCCCCCCCCCSSSSCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCSSSSSSSCCSSSSSSSCCCCCSSSCCCSSSSSCCCSCCCCCSSSSSSSSSCCSSSSSSCCCCCSSSSCCCCCSSCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCSSCCCSSSCCCCCCCCCSSSCCCCCCCCCCCCCCCSSSCCCCSSSSSCCCCCCCCCCSSSSSSSCCCCSSSSSSCCCCCCCSSSSSSSCCSSSSSSSCCCCCSSSSSCCCSSCCCCCSSSSSSSSCCSSSSSSCCCCSSSSCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCSSSSCCCSSCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCSSSSCCCCCCCSCCCCCCCCCSSSCCCCCCCCCCSSSSSCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCSSSSSSSSSCCCCSSSSSSCCCCCSSSSSSSCCCSSSSSSSCCCCCSSSSSSCCCCCCCCCCSSSSSSSSCCSSSSSSCCCCCSSSSCCCCCCSSCCCCCCSSSCSCCCCCCCCCSSSSSSSSCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCSSSCCCCCCCCCCCCCCCCCCSSCCCCSSSSSCCCCCSCCCCCCCCCCCCCCCCCCCCSSSSSSSSSCCCCSSSSSSCCCCCCSSSSSSSSCCSSSSSSSCCCCCCCSSSSCCCCSCCCCCCSSSSSSSSCCSSSSSSCCCCSSSSSCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCSSSSSSSSSCCSSCCHHHHCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCHHHHHHHHHHHHHHHHHHHH SSSCCCSSCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
Confidence
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Prediction |
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCCCCCCSSSSSSSSSCCSSSSSSCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCSSSSCCCCSSSSSSSSCCCCCCCCSSSSSSSSSSCCCCCCSSSSCCCCCCSSCCCCCCCCCSSSSCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCSSSSSSSCCSSSSSSSCCCCCSSSCCCSSSSSCCCSCCCCCSSSSSSSSSCCSSSSSSCCCCCSSSSCCCCCSSCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCSSCCCSSSCCCCCCCCCSSSCCCCCCCCCCCCCCCSSSCCCCSSSSSCCCCCCCCCCSSSSSSSCCCCSSSSSSCCCCCCCSSSSSSSCCSSSSSSSCCCCCSSSSSCCCSSCCCCCSSSSSSSSCCSSSSSSCCCCSSSSCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCSSSSCCCSSCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCCSSSSCCCCCCCSCCCCCCCCCSSSCCCCCCCCCCSSSSSCCCCCCSSCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCSSSSSSSSSCCCCSSSSSSCCCCCSSSSSSSCCCSSSSSSSCCCCCSSSSSSCCCCCCCCCCSSSSSSSSCCSSSSSSCCCCCSSSSCCCCCCSSCCCCCCSSSCSCCCCCCCCCSSSSSSSSCCSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCSSSCCCCCCCCCCCCCCCCCCSSCCCCSSSSSCCCCCSCCCCCCCCCCCCCCCCCCCCSSSSSSSSSCCCCSSSSSSCCCCCCSSSSSSSSCCSSSSSSSCCCCCCCSSSSCCCCSCCCCCCSSSSSSSSCCSSSSSSCCCCSSSSSCCCCCCCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCSSSSSSSSSCCSSCCHHHHCCCCCCCCSSSCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCHHHHHHHHHHHHHHHHHHHH SSSCCCSSCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
1 | 3javA | 0.06 | 0.02 | 0.91 | 0.33 | DEthreader |  | --LEKASHQLVDNPGCATPDDAKVLRSVTLLKQILICRLCYRVRHSQQDYRKNQEYITITALL-NNRKLLEKHITAAEIDFVSLVRKNRE------------------------------------------------------------------------------------------------------------------------------ICKAVLN------P-TN--------------------ADILIETKLV----------------------L-------------------S-RFEFEGVSTGENALEAGEEVWWRVLSYRFAQTMEFVEEYTFLCVIQFILNVRLDYSFIEAIALLLQAFKVQLLVTSQDVDN-KQIKQDLSIKSWVYLISCVSASVRKSRKQQQRNMGAHAVVLELQIP-----KHIN--TVNTSDLGNKKKDDEK----GLLGYIINPL------------------------------------PKELVL----RHNKEL---------IEIVRLD--------------------------------------------------------------FLTKESKLRI-----YYT-ER-------------DEQ------------GSKINDF--F--------------------LRSEDLFNEMNWQKKLRAQPVLWCARNMSFW--------------------------------------------------------------------F-PFKGVRGGTL-P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRLYLLICAMGLFV-----------YREETLLNVIK-----R-GRPI IL---------------------------------ILVYLFSIG---LPVEETEQDKEHSHG-RSGG-----VIIVL--IFGVIID TFADLRSEKQK----------------------------------------------------------------------------------------------------------------------------------------------
2 | 3poyA | 0.23 | 0.17 | 5.28 | 5.17 | SPARKS-K |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HTG-KSADYVNLALKNGAVSLVI NLGSG-------AFEALVEPKFNDNAW HDVKVTRNLRQ VTISV DGITTTGYTQEDYTMLGSDDFFYVG GSPSTADPGSPVSNN FMG C LKEVVYKNLELSRL A K QGDPKMKIHGVVAFKCNVATLDPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPRVDFFAIEMLD GHLYLLLDMGSGTIKIKALQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPE--NKAGLVFPTYGYVG CIRDLFIDGQSKDIRQMAEVQ--STAGV-KPS CSRAKPC LSNPCKNNGMCRDGWNRYVCDCSGT G YLGRSCEREAT-----------------VLSYD G SMFMQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAG--------------RVKLTVNLDPETLFAGYDNEWHTVRVVRRGKSLKLTVDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDY-CELNARFGFRNIIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGDND F IVVE LVKG-YLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTSLHTVKIDTKITTQITA---GARNLDLKSDLYIG GVAKETEG FQG CLASVDL N GRLPD LISDALCNGQIERG CEGPSTTCQDSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNDPGTYIFSKGGQITYKWPP---------------NDRPSTRADRLAIGFSTVQKEAVLVRVDSSLGDY LELHIHQ-GKIGVKFNVGTDD--IAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAGLTIFNSQATIIIGG------------KEQGQPFQGQL SGLYYNGLKVLNMAAEN--DANIAIVGNVRLLEV----------------------------------------------------------------------------------------------------------
3 | 3poyA | 0.23 | 0.16 | 4.94 | 2.16 | MapAlign |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HTGK-SADYVNLALKNGAVSLVI NLGS-------GAFEALVEPKFNDNAW HDVKVTRNLRQ VTISV DGLTTTGYTQEDYTMLGSDDFFYVG GSPSTADLPGSVSNN FMG C LKEVVYKNLELSRL A K QGDPKMKIHGVVAFKCENVTLDPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPRVDFFAIEMLD GHLYLLLDMGSGTIKIKALQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPVFPTEVWTALLNYGYVG CIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSRETAKPCLSPCKNNGMCRDGWNRYVCDCSGT G YLGRSCE--------------------------------------------------REATVLSYDGS---MFMKIQLVM------------HTEAEDVSLRFRSQRILMATTSRDSADTLRLELDAGRV-------------KLTVNLDC IKGPETLFAGYNLNDNEWHTVRVVRRDHTRLEFHNIETGIPSNFIGHLQSLTFNGGFRNIIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGDND F IVVE LVKG-YLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTNLHTVKIDTK-ITT QITA--GARNLDLKSDLYIG GVVHAKEG FQG CLASVDL N GRLPD LISDALFNGQIERG CEGSTTCQEDSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNPGTTYIFSGGGQITYKWPDRPST-----------------RADRLAIGFSTVQKEAVLVRVDSSLGDY LELHIHQ-GKIGVKFNVG--TDDIAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPRQLTIFNSQATIIIG-GK----------EQGQ-PFQGQL SGLYYNGLKVLNMAA--ENDANIAIVGNVRLLEV----------------------------------------------------------------------------------------------------------
4 | 3poyA | 0.22 | 0.16 | 5.05 | 1.05 | CEthreader |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HTG-KSADYVNLALKNGAVSLVI NLGSGAF----EALVEPVNGKFNDNAW HDVKVTRNLRQ VTISV DGLTTTGYTQEDYTMLGSDDFFYVG GSPSTALPGSPVSNN FMG C LKEVVYKNLELSRL A K QGDPKMKIHGVVAFKCENVTLDPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPKVDFFAIEMLD GHLYLLLDMGSGTIKIKALQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPENKAGLVTALLNYGYVG CIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSR-ETAKPC LSNPCKNNGMCRDGWNRYVCDCSGT G YLGRSCEREATVLSYD--GSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGI-------------ITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRN-------IIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGDGNDFIVVELVKGYLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTSNLHTVKIDTKITT QITA--GARNLDLKSDLYIG GVAKAKEG FQG CLASVDL N GRLPD LISDALFCNGIERG CEGPSTTQEDSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNDPGTTYIFSKGGGQITYKWPPNDR-------------PSTRADRLAIGFSTVQKEAVLVRVDSSLGDY LELHIHQG---KIGVKFNVGTDDIAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLFNSQATIIIGGKEQGQPFQ------------GQL SGLYYNGLKVLNMAAENDANIAIVGNVRLLEV------------------------------------------------------------------------------------------------------------
5 | 3poyA | 0.23 | 0.17 | 5.33 | 3.67 | MUSTER |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HT-GKSADYVNLALKNGAVSLVI NLGSGAFE----ALVEPVNGKFNDNAW HDVKVTRNLRQ VTISV DGLTTTGYTQEDYTMLGSDDFFYVG GSPSTADPGSPVSNN FMG C LKEVVYKNNELSRL A K QGDPKMKIHGVVAFKCENVTLDPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPRVDFFAIEMLD GHLYLLLDMGSGTIKIKALQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPVFPTEVWTALLNYGYVG CIRDLFIDGQSKDIRQMAEVQS--TAGVK-PS CSRAKPC LSNPCKNNGMCRDGWNRYVCDCSGT G YLGRSCEREAT-----------------VLSYD G SMFMKIQLPVVMHT EAEDVSLR-----------SQRAYGILMATTSRDSADTLRLELDAG-RVKLTVNLDCIKGPETLFNDNEWHTVRVVRRGKSLKLT-DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNA-RFGFRNIIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGDND F IVVE LVKG-YLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTNLHTVKIDTKITTQIT---AGARNLDLKSDLYIG GVAKEKEG FQG CLASVDL N GRLPD LISDALFCNGIERG CEGPSTCQEDSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNDPGTYIFSKGGQITYKWPPN---------------DRPSTRADRLAIGFSTVQKEAVLVRVDSSLGDY LELHIH-QGKIGVKFNVGTDD--IAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAQLTIFNSQATIIIGG------------KEQGQPFQGQL SGLYYNGLKVLNMAAE--NDANIAIVGNVRLLEV----------------------------------------------------------------------------------------------------------
6 | 3poyA | 0.25 | 0.18 | 5.61 | 5.15 | HHsearch |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HT-GKSADYVNLALKNGAVSLVI NLGSGAF-----EALVPVNGKFNDNAW HDVKVTRNLRQ VTISV DGILTTGYTQEDYTMLGSDDFFYVG GSPSTADPGSPVSNN FMG C LKEVVYKNNDLSRL A K QGDPKMKIHGVVAFKCENVTLDPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPKVDFFAIEMLD GHLYLLLDGSGTIKI-KALQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPENKAGLVTALLNYGYVG CIRDLFIDGQSKDIRQMAEV--QSTAGV-KPS CSREKPC LSNPCKNNGMCRDGWNRYVCDCSGT G YLGRSCEREAT-----------------VLSYD G SMFMKIQ----------LPVVMHTEAEDVSLRFRSQRYGILMATTSRDSADTLRLEL-DAGRVKLTVNLDCIKGPETLFNDNEWHTVRVVRRGKSLKLTVDDQAMTGQMA---------------GDHTRLEHNIET GIITERRYLSSVPSFIGHLQSLTGMDLCKNGDIDCEGFRIIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGGND F IVVE LVKG-YLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTSNHTVKIDTKITTQI-TA--GARNLDLKSDLYIG GVAKAKEG FQG CLASVDL N GRLPD LISDALFCGQIERG CEGTCQE--DSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNDPGTTY FSGGGQITYKWPPNDR---------------PSTRADRLAIGFSTVQKEAVLVRVDSSLGDY LELHIH-QGKIGVKFNVGTDD--IAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAQLTIFNSQATIIIGGKEQ------------GQPFQGQL SGLYYNGLKVLNMAAEND--ANIAIVGNVRLLEV----------------------------------------------------------------------------------------------------------
7 | 3poyA | 0.22 | 0.16 | 5.12 | 4.80 | FFAS-3D |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEY-IATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HT-GKSADYVNLALKNGAVSLVI NLGSGAF----EALVEPVNGKFNDNAW HDVKVTRNLRQ VTISV DGITTTGYTQEDYTMLGSDDFFYVG GSPSTADPGSPVSNN FMG C LKEVVYKNLELSRL A K QGDPKMKIHGVVAFKCENVATLPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPRHDFFAIEMLD GHLYLLLDMGSGTIKIKALQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPENKAGLVFPTENYGYVG CIRDLFIDGQSKDIRQMAE-VQSTAGVKPSCSRETAKPC LSNPCKNNGMCRDGWNRYVCDCSGT G YLGRSCEREATVLSYDGSVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTRLELDAGRVKLTVNLDCIKGPETLFAGYN---------LNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMA------------------------YIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGDND F IVVE LVKG-YLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTSNLHTVKIDTKITT QITAGARN--LDLKSDLYIG GVAKAKEG FQG CLASVDL N GRLPD LISDALFCNGERGCEGPSTTCQEDSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNDPTYIFSKGGGQITYKWPPN---------------DRPSTRADRLAIGFSTVQKEAVLVRVDSSSLGDYLELHIHQGKIGVKFNVGTDD--IAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAGRTIFNSQATIIIGGKEQG------------QPFQGQL SGLYYNGLKVLNMAA--ENDANIAIVGNVRLLE-----------------------------------------------------------------------------------------------------------
8 | 3poyA | 0.18 | 0.12 | 4.05 | 1.88 | EigenThreader |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEEYIATFKGSEYFCYDL----SQNPSDEITLSFKTL--QRNGLMLHTGKSADYVNLALKNGAVSLVI NLGSG------AFEALVEPVKFNDNAW HDVKVTRNLRQ VTISV DGILTTTGYTQEDYTMLGDFF-YVG GSPSTADLPGSPVSNNFLKEVVYKNNDVRLSRL A K QGDPKMKIHGVVAFKCENVATLPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGMIKVDFFAIEMLD GHLYLLLDG---SGTIKALQKKVN D GEWYHVDFQRDGRSGTISVNTLTAPGESEILD----LDDELYLG GLPENKAGLVFPTEVYGYVG CIRDLFIDGQSKDIRQMAEVQSTA--GVPSCSRETAKPC LSNPCKNNGMCRDGWNRYVCCS-----GTGYRSCEREA------------TVLSYDGSMFSQRA--YGILMADSADTLRLELDA---GRVKLTDCIKGPETLFAGYNLND---------NEWVRRGLKLTVDDQQ--------AMT-GQMAGDHTNIETGIITERRYLSSVPSNF--------------------IGHLQSLTFNGMAYI----DLCKNGDIDYCELNARFGFRNIIA-DPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNGDGND F IVVE LVKG-YLHYVF DLG N G-ANLIKGSSNKPLNDNQWHNVMISRDTSHTVKIDT--KIT QITAGARN--LDLKSDLYIG GVVHAKEG FQG CLASVDL N GR---------LPDLISDALEGPSTTCQEDSCSNQGLQQWDGFSCDCSMTSFSGPLCNDIFSKGGGQ----ITYKWPP---------------NDRPSTRADRLAIGFSTVQKEAVLRVDS SSGLGDYLELHIHQGKIGVKFNVG--TDDIAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQG---------QPFQGQLSGLYYNGLKVLNMA AEN---DANIIVGNVRLLEV-----------------------------------------------------------------------------------------------------------
9 | 3qcwA | 0.25 | 0.18 | 5.49 | 9.96 | CNFpred |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIATFKGSEYFCYDLSQNPIQSSSDEITLSF K TLQRNGLML HTGK-SADYVNLALKNGAVSLVI NLGSG-------AFEALVEPKFNDNAW HDVKVTRNLRQ VTISV DGLTTTGYTQEDYTMLGSDDFFYVG GSPSTADLGSPVSNN FMG C LKEVVYKRLELSRL A K QGDPKMKIHGVVAFKCENVALDPIT FETPESFISL PKWNAKKTGSISFDF R TTEPNG LIL F SHGKPKVDFFAIEMLD GHLYLLLDMG-SGTIKIKAQKKVN D GEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLG GLPENKAGLVFPT-NYGYVG CIRDLFIDGQSKDIRQMAE--VQSTAGVK-PS CSREKPC LSNPCKNNGMCRDGWNRYVCDCSGT G YLGRSCEREATVLSYD--------SMFMKIQLPVVMHTEAEDVSLRFRSRAYGILMATTADTLRLELD--AGRVKLTVNLGKGPETLFAGYNLNDNEWHTVRVVRRGK---------SLKLTVDDQQAMTGQMAG---DHTRLEFH----NIETGIITERRYLSSVPSNFIGHLQSLT---FNGMAYIDLCKNGDIDYCELN-ARFGFRNIIADPVTFKTKSS YVALATLQAYTSMHLFFQF K T TSLDGLILYNSGGND F IVVE LVK-GYLHYVF DLG N GANLIKGSSNKPLN D N Q W HNVMISRDTNLHTVKIDTKITTQITA---GARNLDLKSDLYIG GVAK-KEG FQG CLASVDL N GRLPD LISDALFCNQIERG CEGPSTTCEDSCSNQGVCLQQWDG FSC D CSMTSFSG PLCNDPTTYIFSKGGQITYKWPPNDRP---------------STRADRLAIGFSTVQKEAVLVRVDSSLGDY LELHIH-QGKIGVKFNVGT--DDIAIEESNAIIND GKYHVVRFTRSGGNATLQVDSWPVIERYPAQLTIFNSQATIIIGGKEQ------------GQPFQGQL SGLYYNGLKVLNMAAEND--ANIAIVGNVRLV------------------------------------------------------------------------------------------------------------
10 | 6g2dC | 0.05 | 0.02 | 0.77 | 0.33 | DEthreader |  | -------------------------------------------------------------------------------------WGHASE----------------------LPWSGSGLR--------KRILNVPQELY----------------KASEGGKGINLFRQVQ--PIFVMR--A---------------------------SVQRRH--ATIATPAVFEHMEQCAKLAKMVGYATV-----GSFFHCTEMVAD--------------PLYRIKDIRMM--YGVSPWGDSPID---------AQEL----S--FGHCFSWGEEAISN------EL--RGD-----GLLLSYDGSS--RIQSTA----------RGEKLHRVFYVSKVKD--------------TSV---------------------------------QVLASPSYEHVLQKLISETSIFD----YRRA-IA-ELNSVQFQFMLPSHCQRAIVTDSAQIMFQGPLVKLRLPGGNEIGMVAWKMTFKSPEYPGRDII--------ELARAEGIPNE--------YMPKSVHSS-PLLN SKDPIDRIIEFVPHPTQKGQWLSGF-DY----------------------LG-IPV------------IKDFNREGLPLM-----------QPVLVYIP--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPGRMQEKGVISLLLEDLVKKKIHNANELT-QIQA------VEVEGT-----------------------------V-KAY-VWDNNKDLAEWLEKQLTSIE---KC-SR-YVLKQIRSLV--Q-NPEVAMDSIIHMTQHISPT----------------------------------------------------------------------------------------------------
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.5526
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 3poyA | 0.72 | 1.06 | 0.230 | 0.726 | model1_3poyA.pdb.gz
| 2 | 5cskA | 0.33 | 9.72 | 0.037 | 0.504 | model1_5cskA.pdb.gz
| 3 | 6g2dC | 0.32 | 9.84 | 0.040 | 0.497 | model1_6g2dC.pdb.gz
| 4 | 6mfzA | 0.30 | 10.34 | 0.030 | 0.485 | model1_6mfzA.pdb.gz
| 5 | 6h02A | 0.28 | 9.61 | 0.042 | 0.433 | model1_6h02A.pdb.gz
| 6 | 6um1A | 0.28 | 9.91 | 0.038 | 0.440 | model1_6um1A.pdb.gz
| 7 | 4xqkA | 0.28 | 9.91 | 0.027 | 0.443 | model1_4xqkA.pdb.gz
| 8 | 4bedA | 0.28 | 10.44 | 0.030 | 0.460 | model1_4bedA.pdb.gz
| 9 | 6eqoA | 0.28 | 9.92 | 0.043 | 0.436 | model1_6eqoA.pdb.gz
| 10 | 5t8vA | 0.28 | 9.87 | 0.043 | 0.433 | model1_5t8vA.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0003824 | 0.67 | catalytic activity
GO:0016740 | 0.65 | transferase activity
GO:0047291 | 0.64 | lactosylceramide alpha-2,3-sialyltransferase activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0044699 | 1.00 | single-organism process
GO:0009987 | 0.95 | cellular process
GO:0044763 | 0.93 | single-organism cellular process
GO:0006928 | 0.57 | movement of cell or subcellular component
GO:0032502 | 0.55 | developmental process
GO:0065007 | 0.54 | biological regulation
GO:0044767 | 0.54 | single-organism developmental process

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 0.82 | cell part
GO:0044425 | 0.62 | membrane part
GO:0044424 | 0.62 | intracellular part
GO:0016021 | 0.52 | integral component of membrane

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 1hn0A | 0.220 | 9.31 | 0.031 | 0.333 | 4.2.2.20 | NA
| 2 | 0.060 | 2pdaA | 0.217 | 9.51 | 0.032 | 0.332 | 1.2.7.1 | NA
| 3 | 0.060 | 2vuaA | 0.117 | 7.18 | 0.036 | 0.153 | 3.4.24.69 | NA
| 4 | 0.060 | 3ecqB | 0.253 | 9.96 | 0.031 | 0.399 | 3.2.1.97 | 277
| 5 | 0.060 | 1z0hB | 0.124 | 5.27 | 0.026 | 0.144 | 3.4.24.69 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.02 | 2h0bD | 0.131 | 1.03 | 0.266 | 0.132 | 0.31 | CA | complex1.pdb.gz | 221,314,329
| 2 | 0.01 | 2vz9B | 0.237 | 10.18 | 0.025 | 0.375 | 0.11 | NAP | complex2.pdb.gz | 234,235,236,313,314
| 3 | 0.01 | 2y0pA | 0.173 | 8.98 | 0.033 | 0.256 | 0.12 | TD7 | complex3.pdb.gz | 224,312,313
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.