GO:0003824	F	0.51	catalytic activity
GO:0004842	F	0.45	ubiquitin-protein transferase activity
GO:0019899	F	0.35	enzyme binding
GO:0042802	F	0.34	identical protein binding
GO:0004871	F	0.33	signal transducer activity
GO:1901363	F	0.24	heterocyclic compound binding
GO:0097159	F	0.24	organic cyclic compound binding
GO:0046872	F	0.20	metal ion binding
GO:0030674	F	0.19	protein binding, bridging
GO:0003676	F	0.19	nucleic acid binding
GO:0038023	F	0.17	signaling receptor activity
GO:0046914	F	0.16	transition metal ion binding
GO:0019901	F	0.16	protein kinase binding
GO:0003723	F	0.14	RNA binding
GO:0019903	F	0.13	protein phosphatase binding
