D-I-TASSER Q9NPP4-D3

D-I-TASSER results for Q9NPP4-D3

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q9NPP4 (599 residues)
SFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESG
KGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTF
MAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGA
LTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGES
AGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLA
AVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSA
LSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAED
TGGIHMEEAPETYYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEE
VPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLK
QLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| SFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA
Prediction	CCCCCCCCCCCCCCCSSHHHSSSCCSSSSSCCCCCCSCCSCCHHHHHCCCCSSSSSCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCSSSSSSCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCSSSSSSCCCCCCHHHHHHHHHHHHHCCCCCCSSSSSSCHHHHHHHHHCCCCSSSSSCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSSSSSCCCCCHHHHHHHHHHHCCCCCCCCCSCCCCCCCCCHHHHHHHHHHHHCCCCCCSSSSSCCCCCCCHHHHHHHHHHHHHCCCCCSSCCCCCCCCHHHHHHHHHHHHHHCC
Confidence	98777788788886120221555327999637665111011055551459879999289997899999999999949743356641899972401122599999999733578989899999999668846999818302131355899999961457897799996748987503214728999379999999999998278999999999970889999999899999999998403335543211110158888766677776424433245678889988511178999999999998735430245447347765467887631047899998647888998899987531126888999999860311112332148999999961337888887777652322431566665322233214315666644278999999987765666577664331467889999999985187715787517889849999999998044444432123678887989999999997047678278501367776536799999997117631276272788981568999999986259
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| SFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA
Prediction	72441310112561304054201404123424654433423055115533210000021400000000000100034405214401000000022145201410051006352504463024103535200000000011023512510230034220250000000012005303521412020240347202300340046610540152047253012001000000000000122534432330232443242232342034213344044112300221143245103300310020044342341423443123343043044332330032022220120002102332334203510340034220223274023100200230240320030030202343242344335414414334242222134523420330041032243022010410330141043014103414300201045250335004101300636405404403031320226002100300430540210202335134422103300500440210220002103023510400310142037
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCCCCCCCCCCCCCSSHHHSSSCCSSSSSCCCCCCSCCSCCHHHHHCCCCSSSSSCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCSSSSSSCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCSSSSSSCCCCCCHHHHHHHHHHHHHCCCCCCSSSSSSCHHHHHHHHHCCCCSSSSSCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSSSSSCCCCCHHHHHHHHHHHCCCCCCCCCSCCCCCCCCCHHHHHHHHHHHHCCCCCCSSSSSCCCCCCCHHHHHHHHHHHHHCCCCCSSCCCCCCCCHHHHHHHHHHHHHHCC
SFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA

5irlA

0.12

0.08

2.89

0.83

DEthreader

---------------T------SLQVHLLWATGQD-QFLFVFLL-HPDRI--LLTFDGFDEF-----TLLFNLLQGNLLKNAR----KVL-S--------------RK----------------------YVRTEFNLKG---------------------------LP--------------------L--AGLMCCYVFSAQQLQAAQVDDISLGFLVQEFLHI-TFQ-CF--L-----A--AF-YL-------V-LSTDVPTASLRY---L-FN--------------TEPHNLQITAAL----RRRACARWCLARSLHKHFRS-IP-A--M--PGFLWLIRSLYEMQE-----ERLAQEAVRGLNVEHLKLCVGPAECAALAFVLR-H-LR--RPVALQLDNSVGDIGVEQLLP-C------LGACKALYLRNNISRGICKLIEHALHCEQLQKLALFNNKLTDGCAHSVAQLLACKQNFLALRLGNNHITAEGAQVLAEGLRDNS--SLQFLGFWGNKVGDKGAQALAEALSDHQSLKWLSLVGN-NIG-SVGAQALASMLEKNVALEELCLAANNIGAEALLALNDTILEVWL

6j5tG

0.16

0.14

4.69

1.71

SPARKS-K

CQLQYKKSKRLQEINERITKIKSSPVYDHTQVVGLEGDKRKIKEWLDSQLLIMAFVGMGGLGKTTIAQEVFNDK-----EIEHRFERRIWVSVSQTFEQIMRSILRNLGDASVGDDIGTLLRKIQQYGKRYLIVMDDVWDKNLSWWDKIYQGL--PRGQGGSVIVTTRSESVAKRVQARDKTHRPELLSPDNSWLLFCNVAFAAERPEL--EDVGKEIVTKCKGLP-------------LTIKAVGGLLLCKVYHEWRRIAEHFQDELRGNTETDNVMSSLQLSYDELP-------SHLKSCILTLSLY----PEDCVIPKQQLVHGWIGEG--FVMWRNGRSATESGEDCFSGLTNRCLIEVVDKTYSG----TIITCKIHDMVRDLVIDIAKNPEGLNCRHLGISGNFD--------EKQIKVNHKLRGVVSTTKTGEVLNSDLAKKFTDCKYLRVLDISKS-IFDAPLSEILDEIASLQHLACLSLSNTH----PLIQFPRSMEDL--HNLQILDASYCQLKQ-----LQPCIVLFKKLLVLDMTNCGSLEFPKGIGSLLSEVKNLTNLRKLGLSLTRIEEEELDSLINLSKLMSI

5irlA

0.16

5.16

1.42

MapAlign

-----IVAAQSRFLNLCLEDIYTENTLEVRT------AALGLEELF-SDADTVLVVGEAGSGKSTLLQQVHLLWATGQD--FQEFLFVFPFSCRLQCVARPLSVMTLLFEHCCWPDQQDVFQFLLDHPDRILLTFDGFDEFKPTSVQTLLFNLLQGNLLNARKVLTSRPDAVAFLRKYVRTEFNLKGFSEEGIELYLRKCHEPGVADRLIHLLQTTSALHGLCHLPVFSWMVSKELLDMYLLILQHFLTLLRLGQLALWCFLAAFYLVLSTDVPTASLRYLFLLQKTEPHNLQITAAFLAGLLSREHSERSLLRRRACARWCLARSLHKHFRSIPAMPGFLWLIRSLYELAQEAVGVGPAECAALAFVLRPVALQLDHNSV---GDIGVEQLLPCLGACKALYLRDNNISDRGICKLIEHALHCEQLQKL-ALFNNKLTDGCAHSVAQLLACKQNFLALRLGNNHITAEGAQVLAEGLRDNSSLQFLGFWGNKVGDKGAQALAEALS--DHQSLKWLSLVGNNIGSVGAQALASMLEKNVALEELCLAANHL-Q-DAGVCSLAEGLKRNSSLKVLKLSNNCITFVGAEALLQALTILEV

5irlA

0.17

0.16

5.39

1.02

CEthreader

---------EAAACKKYMSKLRTIVAAQSRFLNLCLEDILGLEELFS-DADTVLVVGEAGSGKSTLLQQVHLLWATGQD--FQEFLFVFPFSCRQLQCVARPLSVMTLLFCWPDVGQQDVFQFLLDHPDRILLTFDGFDEFKTSVQTLLFNLLQGNLLKNARKVLTSRPDAVSAFRKYVRTEFNLKGFSEEGIELYLRKCHRPGVADRLIHLLQTTSALHGLCHLPVFSWMVSKCHQEDMYLLILQHFLRHASLLQGRLPTLLRLGQLRYLFNCSTVAALLQKTEPHNLQITAAFLAGLLSREHRDLLAACQASERSLLRRRACARWCLARSLHKHFRSIPAMPGFLWLIRSLYEMQEERLAQEAVRGLNVEHLKLTFCGVGPAECAALAFVLRHLRRPVALQLDHNSVRDNNISDRGICKLIEHALHCEQLQKLALFNNKLTDGCAHSVAQLQNFLALRLGNNHITAEGAQVLAEGLRDNSSLQFLGFWGNKVGDKGAQALAEALSDH--QSLKWLSLVGNNIGSVGAQALASMLEKNVALEELCLAANHLQ--DAGVCSLAEGLKRNSSLKVLKLSNNCITFVGAEALLQALASNDT

4kxfK

0.58

16.64

1.31

MUSTER

AFLNFYPLGEDIDIIFNLEKTFTEPIMWKKDHRHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVITCAIQMGRTAGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYTCGSSTEATRAVMRHLAMVYQHGSLQGLSVTKRP---RQEIQSLRNTTEQDVLKAINVNSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFVKLDFYERATNKLNKQDIKYLGKIFSSATNLRLHIKRCAAMAGRLSSVLRTCKNMHTLMVEASPLTTDDEQYITSVLGNLKNLERLILDDIRMNEEDAKNLAEGLRSLKSCDLQEMKLVACCLTANSVKVLAQNLHNLIKLSILDISENYLEKDHTSLPKLLKQLEGTPGLAKLGLKNWRLRDEEIKSLGEFLEMNPL

6j5tG

0.15

0.13

4.28

1.91

HHsearch

DCQQYKKSKRLQEINERITKIKSSPVYDHTQVVGLEGDKRKIKEWLFSQLLIMAFVGMGGLGKTTIAQEVFNDKEIEHR-----FERRIWVSVSQTTEQIMRSILRNLGDASVGDDIGTLLRKIQQLGKRYLIVMDDVWDKNWWD--KIYQGLPRG--QGGSVIVTTRSESVAKRVQRDDKTHRPELLSPDNSWLLFCNVAFAADERPELEDVG-KEIVTKCKGLPL-------------TIKAVGGLLLCKDYHEWRRIAEHFQDELRLSYLPSHLKSCILTLSLYPED--------------------------CVIPKQQLVHGW--IGEGFVMWRNGRSATESGEDCFSGLTNR-CLIEVVDKTYSG---TIITCKIHDMVRDLVIDIAKKDSNCRHLGISGNFDEKQ-------------IKVNHKLRGVVSTTKTLNSDLAKKFTDCKYLRVLDISKSIF-DAPLSEILDEIASLQHLACLSLSN----THPLIQFPRSM--EDLHNLQILDASYCNLK-----QLQPCIVLFKKLLVLDMTNCG------SLECFPKGIGSLVKLEVLLGFKPARNGCKLSEVKNLTNLRKL

4kxfK

0.73

0.72

20.47

2.52

FFAS-3D

AFLNFYPLGEDIDIIFNLEKTFTEPIMWKKDHRHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVITCAIQMGRQAGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYTCGSSTEATRAVMRHLAMVYQHGSLQGLSVTKRP---RQEIQSLRNTTEQDVLKAINVNSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFVEMKLVACCLTANSVKVLAQNLHNLIKLSSENYLEKDGNEALQELIGRLGVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLKNWRLRDEEIKSLGEFLEMNPLRDLQQLDLAGHCVSSDGWLYFMNVFENLKQLVFFDFSTEEFLPDAALVRKLSQVLSKLTLLQEVKLTGWEFDDYDISAIKGTFKLVT-

4kxfK

0.40

0.37

10.89

1.23

EigenThreader

DIIFNLEKTFTE----------PIMWKKD---HRHHRVEQLTGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLDGYNEF-HPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVITCAIQMGRQGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSL-----------YGNLLLYTCGSSMRHLAQGLSVTKRPRQEIQSLRN-------------TTEQDVLKAINVNSFVECGINLFSESMSQEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFVKLDFYERATPPRAVSLFFNWGLRSLKKMRLTHLSDIGEGMDYIVKSLSEESCDLQEMKLCCL--TANSVKVLAQNLHNLIKLSILDISNYLEKDGNEALQELIGRLGVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLKNWRLRDEEIKSLGEFLEMNPLRDLQQLDLAGHCVSSDGWLYFMNVFENLKQ

4kxfB

0.60

0.59

16.94

2.64

CNFpred

AFLNFYPLGEDIDIIFNLEKTFTEPIMWKKDHRHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVITCAIQMGR-AGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYTCGSSTEATRAVMRHLAMVYQHGSLQGLSVTKRPLWRQEMIQSLRNTTEQDVLKAINVNSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFVKLDFYERATPPRAVSLFFN-------KQEFKTLEVTLRD-NKQDIKYLGKIFSATNLRLHIKR-CAAMAGRLSSVLRTCKNMHTLMVEASPLTTDDEQYITSVTGLGNLKNLERLILDDIRMNEEDAKNLAEGLRSLKKMRLLHLTHLS--DIGEGMDYIVKSLSESCDLQEMKLVACCLTANSVKVLANLHNLIKL

6npyA

0.10

0.07

2.39

0.83

DEthreader

--------------------------------------------------------IKE-----------------------------------------------------------------------------------------------------------HRI----------DEHSEVTVVFTALFYIHCREVSLVTQRG--LMDGFDE--LLITTRPVALEKLQ-L-AADGIWNQKILFEESRVSLRMNLFQYSFIHMTFQEFFAA-------------------SRLKLPSRENYGKFEKGYLIKLQIQPSQLELFYCLYEMQ-EED-VQRAMD-YFPK-IE------I-GFLHNMPKEEEEEKEGRHLDMVQCVLPSSSHAA-C---SHGLVNSHLTS--SFCRGLFSVL-----STSQSLTELDLNSLGPGMRVLCETLQHGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKK-LWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK-LGLVNSGTCCSALSVLSQNLTHVLE

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.5908

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	5irlA	0.82	3.86	0.162	0.947	model1_5irlA.pdb.gz
2	6npyA	0.75	4.61	0.123	0.923	model1_6npyA.pdb.gz
3	4kxfK	0.71	5.42	0.327	0.940	model1_4kxfK.pdb.gz
4	6b5bA	0.47	5.37	0.148	0.591	model1_6b5bA.pdb.gz
5	4xqkA	0.47	7.17	0.064	0.713	model1_4xqkA.pdb.gz
6	7crcA	0.46	6.67	0.084	0.659	model1_7crcA.pdb.gz
7	6eqoA	0.45	7.51	0.054	0.711	model1_6eqoA.pdb.gz
8	6bcuW	0.44	7.06	0.061	0.669	model1_6bcuW.pdb.gz
9	5julA	0.44	6.25	0.079	0.596	model1_5julA.pdb.gz
10	4kf7A	0.44	7.16	0.043	0.666	model1_4kf7A.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0003824	0.74	catalytic activity
GO:0016740	0.72	transferase activity
GO:0004842	0.71	ubiquitin-protein transferase activity
GO:0030234	0.64	enzyme regulator activity
GO:0061134	0.63	peptidase regulator activity
GO:0004857	0.63	enzyme inhibitor activity
GO:0004869	0.61	cysteine-type endopeptidase inhibitor activity
GO:0097367	0.55	carbohydrate derivative binding
GO:1901363	0.53	heterocyclic compound binding
GO:0097159	0.53	organic cyclic compound binding
GO:0005524	0.51	ATP binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0065007	0.89	biological regulation
GO:0050789	0.89	regulation of biological process
GO:0050794	0.87	regulation of cellular process
GO:0048583	0.79	regulation of response to stimulus
GO:0009987	0.79	cellular process
GO:0019222	0.75	regulation of metabolic process
GO:0060255	0.74	regulation of macromolecule metabolic process
GO:0044699	0.74	single-organism process
GO:0009966	0.74	regulation of signal transduction
GO:0050896	0.73	response to stimulus
GO:0031323	0.73	regulation of cellular metabolic process
GO:0080090	0.72	regulation of primary metabolic process
GO:0065009	0.71	regulation of molecular function
GO:0044763	0.71	single-organism cellular process
GO:0006950	0.70	response to stress
GO:0048519	0.69	negative regulation of biological process
GO:0050790	0.68	regulation of catalytic activity
GO:0048523	0.68	negative regulation of cellular process
GO:0032268	0.68	regulation of cellular protein metabolic process
GO:0006952	0.68	defense response
GO:0010941	0.67	regulation of cell death
GO:0010468	0.67	regulation of gene expression
GO:0042981	0.66	regulation of apoptotic process
GO:0051336	0.65	regulation of hydrolase activity
GO:0044092	0.64	negative regulation of molecular function
GO:0043281	0.64	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031324	0.64	negative regulation of cellular metabolic process
GO:0010605	0.64	negative regulation of macromolecule metabolic process
GO:0016043	0.63	cellular component organization
GO:0002376	0.63	immune system process
GO:0043066	0.62	negative regulation of apoptotic process
GO:0032269	0.62	negative regulation of cellular protein metabolic process
GO:0048518	0.61	positive regulation of biological process
GO:0043154	0.61	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0022607	0.61	cellular component assembly
GO:0010629	0.60	negative regulation of gene expression
GO:1903047	0.59	mitotic cell cycle process
GO:1902589	0.59	single-organism organelle organization
GO:0007010	0.59	cytoskeleton organization
GO:1990001	0.58	inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0090307	0.58	mitotic spindle assembly
GO:0009605	0.58	response to external stimulus
GO:0051707	0.56	response to other organism
GO:0048522	0.56	positive regulation of cellular process
GO:0098542	0.55	defense response to other organism
GO:0048584	0.55	positive regulation of response to stimulus
GO:0002682	0.55	regulation of immune system process
GO:0050776	0.54	regulation of immune response
GO:0031347	0.54	regulation of defense response
GO:0050778	0.53	positive regulation of immune response
GO:0042742	0.53	defense response to bacterium
GO:0009893	0.53	positive regulation of metabolic process
GO:0051606	0.52	detection of stimulus
GO:0045088	0.52	regulation of innate immune response
GO:0031349	0.52	positive regulation of defense response
GO:0010604	0.52	positive regulation of macromolecule metabolic process
GO:0008219	0.52	cell death
GO:0006954	0.52	inflammatory response
GO:2000112	0.51	regulation of cellular macromolecule biosynthetic process
GO:0051171	0.51	regulation of nitrogen compound metabolic process
GO:0045089	0.51	positive regulation of innate immune response
GO:0031325	0.51	positive regulation of cellular metabolic process
GO:0016045	0.51	detection of bacterium
GO:0012501	0.51	programmed cell death
GO:0044093	0.50	positive regulation of molecular function
GO:0006810	0.50	transport
GO:0006355	0.50	regulation of transcription, DNA-templated
GO:0002218	0.50	activation of innate immune response

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005737	1.00	cytoplasm
GO:0043227	0.73	membrane-bounded organelle
GO:0032991	0.70	macromolecular complex
GO:0043234	0.67	protein complex
GO:0044444	0.64	cytoplasmic part
GO:0043229	0.62	intracellular organelle
GO:0044446	0.61	intracellular organelle part
GO:0043231	0.58	intracellular membrane-bounded organelle
GO:0005634	0.55	nucleus

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	2vz8B	0.349	7.77	0.055	0.569	2.3.1.85	63
2	0.060	1l8aA	0.334	8.28	0.039	0.573	1.2.4.1	415
3	0.060	2jfdA	0.190	6.89	0.031	0.282	2.3.1.85	NA
4	0.060	1bxrA	0.380	7.66	0.046	0.606	6.3.5.5	NA
5	0.060	1ogmX	0.339	7.45	0.046	0.531	3.2.1.11	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	3lqrB	0.382	5.95	0.095	0.504	0.72	ATP	complex1.pdb.gz	22,60,61,62,63,64,65,137,168,226,227,230
2	0.01	1u6g0	0.398	6.91	0.066	0.588	0.54	III	complex2.pdb.gz	62,66,137
3	0.01	1a9x1	0.382	7.58	0.046	0.603	0.55	III	complex3.pdb.gz	57,63,65

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.