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# D-I-TASSER results for Q9P2K9-D1

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Input Sequence in FASTA format

>Q9P2K9 (1392 residues) MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGF WSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFD ALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASL GGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHA AVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHE IERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQD LADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRA KFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYIL TSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINT YRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC CWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQ GPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHW VLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEG ISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQG HPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPS RKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSS SPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGV NRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSI SSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDY LRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAV FTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL LAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGK IVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQS GYKIPLPAGASL

Predicted Secondary Structure

Sequence

20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380
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Prediction
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCSSSSSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCSSS HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCSSSSSSCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCSSSSSSCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCSSCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCSSSCCCCCCCCCCCCCCCCCSSSCCCCCCCCCHHHHHHHHHHHHCCCCSSCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSCHHHHHHHHHHHHHHHCCSSSSS HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSSSSCCCCCCC
Confidence
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Prediction |
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map | Distance Map | Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank | PDB hit | ID1 | ID2 | Cov | Norm. Zscore | Downloadalignment |  | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 1260 1280 1300 1320 1340 1360 1380 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SS Seq | CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCSSSSSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCSSS HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCSSSSSSCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCSSSSSSCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCSSSCCCCCCCCCCSSCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSCSSSCCCCCCCCCCCCCCCCCSSSCCCCCCCCCHHHHHHHHHHHHCCCCSSCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSCHHHHHHHHHHHHHHHCCSSSSS HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSSSSCCCCCCC
1 | 6tbuA | 0.15 | 0.09 | 3.11 | 0.51 | CEthreader |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SERMNWYYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETDHHGALFSNPSDLWESSPRKEYSHFVVQRINATDSLFDLNGLLAMCQLQDQITEVPSYRAF CEPE---------MLTTECCRPWS LPNYAAMLANKSSCFDLTTEDVTSLHTLLLGCYEKRLNIVFNVLNFLTDFSFIVYLKYAMIFIPVAQSNRLLPLFHEWEDV---------------ELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTG-SAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVV IIG I GAD D V FLFLKIWHC-VLTESLENIMALTMRHAAASMFVT S L T T AGAFYASYSSSITAIKCF GIFAGTVVVTNYLLMITWLP ASVSIMERLFK--------------------------------------------------------------------------------------KSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKH---------------------------------------------------PFEVYSSLKQQFWFEKPYNFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKELPNCFIENLIDYMKRRCIPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAFTPLL----------------------------------------------------------------------------------------------------------------------------------------------------------VKALVIEFESNVAYSTIYANIRQFYE SVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCF TVNI LISIYAVLTVSLSIFNTVAVLILLG WQLNILESIAVSTAIGLAV DFSLHYGIHYRMS-----------PVKERLAATQFVLSRIIGPTVMAATT TGLAGGIMMASNILPYIQIGVFLVVVMIV SWFYATFFLMSL LRVAGPQHGFLEL---------------------------------------
2 | 6r4lA | 0.10 | 0.07 | 2.54 | 1.10 | EigenThreader |  | ATCAMYGNCGKKSV---------FGNELPCPVPRSFEPPVLSDEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLIACLKNFNNLFCHFTC----AADQGRFVNITKVEKSKESWASEFYDS--------CKNIKFSATNGYAMDLIGGSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKHLKPLKDGVC----KVGPLPFAFMWYYLTNFFNGKLANLFTKVGQFSVEYATLETDPINLWVSKNSNFGPFY-RTEQI FVVNET--GPVLSYETLHWWFDVENFITEELQS----SENIGYQDLCFRPTEDSTCVIESFTQY FQGAL--------PNKDSWKRELQECGKF--------PVNCLPTFQQPLKTNLLFFVVTLLLTNHT-----------QSANRWEERLEEYLLDLKVGLRISFNTEISLEKELNNN---------NTVAISYLMMFLYATWARLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMP A V HNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITSFLKTFYFKMLTQ----------------------------------------------------------------------------------------KRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGK----------------------------------------------------------------------------------------------------------------------------------------FTTCERDSLANVLEQERHRSTITEPLANWLDDYFMF---------------LNPQNDQCCRLKKGTDEVC------------------PPSFPSRRCETC------------------------FQQGSWNYNMSGFPEGKDFMEYLSIWI--NAPSDPCPLGGRAPYSTAETSVSASVFRTAHH-PLRSQKDFIQAY S DGVRI----------SSSFPELDMFAYSPFY---------IFPLTLKLIGSAIILIFFISSV FLQNIRSSFLLALVVTMIIVDIGALMALLGISLNA VSLVNLIICV GLGVEFC V HIVRSF----TVVPS----ETKKDANSRVLYSLNTIGESVIKGITLTKFIGVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPA L LSLFGGE---------------------------------------------
3 | 6tbuA | 0.17 | 0.10 | 3.34 | 2.87 | FFAS-3D |  | ----------------------------------------------------SE----RMNWYYHVLARRPY---L VVVSIAVYCVACIIVALVLNKLPDFSDPTLGF ETRGTKIGERLTAWYNLLQETDHH-----------------------------------------------------------------------GALFSNPSD LWESSPRKE-----------------------------------------------------YSHFVVQRINATDSLFDLNGLLAMCQLQDQITEVPSYRAF CEPE---------MLTTECCRPWS LPNYAAMLANKS----SCFDLTTEDVTSLHTLLLG-----------CYEKRLNIVFNVLNFLTDFSFIVYLKYAMIFIAQSNRLLPLFHEWED--VELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTG-SAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVV IIG I GAD D V FLFLKIWHCVLT-ESLENIMALTMRHAAASMFVT S L T T AGAFYASYSSSITAIKCF GIFAGTVVVTNYLLMITWLP ASVSIMERLFKKSI--------------------------------------------------------------------------------------NRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVPGLQLPEKSHFQLFVSKHPFEVYSSLKQQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WFEKPYNFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYD-NNFNVSSRPAQLWILDFCQSVRQQPFYKELPNCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKEAFTPLLVKALVIEF E SNVAYSTIYANIRQFYESVEHWFQMQ LKTAPPELQG---GWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCF TVNI LISIYAVLTVSLSIFNTVAVLILLG WQLNILESIAVSTAIGLAV DFSLHYGIHYRMSPV-----------KERLAATQFVLSRIIGPTVMAATT TGLAGGIMMASNILPYIQIGVFLVVVMIV SWFYATFFLMSL LRVAGPQHGFLE----------------------------------------
4 | 6v3fA | 0.13 | 0.10 | 3.38 | 3.13 | SPARKS-K |  | ---------LYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRIFACCSTKQLLSLESSMSITKALCSDNFVSLHCPDINVPPAVVAAFYQRSFAEKAYESCS---QVRIPAAASLAVGSGVYGSALAQ RWLNFQGDTGNGLEPGQALPDGIQPLNGKIAPCNESQGDDS AVCAASCPVIPPPEALRPSIIIFTAVFVLLLRVVSNRNKLSPHTILGRFFQNWGTRVASTDPVELWSAPKSQFHDEHFGPFFRTNQIFVTA RNRSSSGILSLDFLLELLELQERLRHLQSLQDICYAPLN----PYNTSLSDCC-VNS LLQY FQNNRTMLTANQTLNG QTSLDWKDHFLYCANAPLDGTSLLSCMADYGAPVFPFLAVGGYALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESFQSDKFQ VAFSAERSLEDEINR TTIQDLPVFAVSYIIVFLYISLAVESKATLGLGGVIVVLGAVLAAMGFYSYLG-VPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPQREAHIGRTLGSVAPSMLLCS LSEAICFFLGALTPMP A VRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPD-------------------------VLCKEKEGL----------------------------------------------------LLRFFRKIYAPFLLHIRPVVMLL FLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEPPVYFVTTS G---------------------------FNFSSE AGMNATCS----------------------------SAGCKSF--------------SLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLT--------------PSSSCCRLY---IRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRP----------------------------------------------------------------------------TAEQFHKYLPWFLN--------------------------DPPNIRCPKGGLAA--YRTSVNLSSDGQVIASQFMAYHKPLRN--SQDFTEALRASRLLAANITADLRKVPGTDEVFPYTISN--VFYQQYLLPEGIFTLALCFVPTFVVCYLLLLDMCSGILNL L S IIMILVDTIGLMAVWGISYNA VSLINLVTAV GMS VEFVSHITRSFAVS----------TKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLAS--------------------------------
5 | 6v3fA | 0.15 | 0.10 | 3.22 | 3.79 | CNFpred |  | ------------------------------------------------------------------------WLALIIIFTAVFVLLSAVLVRLRVVSN---------LSPHTILGRFFQNWGTRVA---------------SWPLTVLALSFIVVIALAAG----------------------------------------FIELTTDPVELWSA--------------------KSQARKEKSFHDEHF------------------GPFFRTNQI FVTARN-FSGILSLDFLLELLELQERLRHLQSLQDICYAPLNPY----NTSLSDCCV-NS LLQY FQNNRTLLMLTANQTLTSLVDWKDHFLYCANAPLCMADYGAPVFPFLAVGGYEAEALIITFSLNN YP----ADDPRMAQAKLWEEAFLKEMESFQSDKFQ VAFSAERSLEDEINR TTIQDLPVFAVSYIIVFLYISLALGSKATLGLGGVIVVLGAVLAAMGFYSYL-GVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMEQREAHIGRTLGSVAPSMLLCS LSEAICFFLGALTPMP A VRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLC------------------------------------------------------------------------------EKEGLLLRFFRKIYAPFLLHIRPVVMLL FLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFFLNRYLEGPPVYFVTTS---------------------------GFNFSSE AGMNATCSSAGCK------------------------------------------SFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTP--------------SSSCCRLYIR-----GPHKDEFCPSTDTSF----------------------------------------------------NCLKNCMNRT---------------GPVRP--------TAEQFHKYLPWFLND-----PPNIRCPK--GGLAAYRTSVNLSS---------------------DGQVIASQFMAYHKP--LRNSQDFTEALRASRLLAANITADLRKVPGTFEVFPYTI--SNVFYQQYL-PEGIFTLALCFVPTFVVCYLLLLDMCSGILNL L S IIMILVDTIGLMAVWGISYNA VSLINLVTAV GMS VEFVSHITRSFAVSTK-----------PTRLERAKDATVFMGSAVFAGVMTNFPGILILGFAQAQLIQIFFFRLNLLITLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLA---------------------------------
6 | 6yejA | 0.06 | 0.02 | 0.94 | 0.33 | DEthreader |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDAESDVRMVADE-CLNKVIKALMLDDTHANYKLEFGGFLRSALDVLSQEVCQKKQDLAQAIIPNIFFIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLLVQQCHKENEDKWRLSRAPSSLRPVVLISQST-----------------------------------------Q------DSALLEGAELVNRIPAEDMNAFMMNSEF-NL--SLLAPCLSL-GMSEISGGQKSALFEAAREVTLARVSGTVQQ---------------------AALYQSLPTLARTLEALSWHLIHEQIPLSL--------------------------------QPGEQ-LS---ACEMVAEM--LVYSPKPGGDFGTAFPEIPV------------------------------TSRTQFE-----WATLLGVL----------------VL-AMTAGLYKLGQVSIHVWLGNSITP----IH-CSQFLLELY-----------------ILISEVVRSLLVVSFNQFELMYVTLTELRRVHPS--EILAQ-LV-------------------S--RSSHL------DYLLSNLKIAHVQQVLVMCATA----GEFSSIIQMGSLVKLSV DRVNVHSPHRAMAA-------------------------------FPCE-RV--R-------------------------------D-FPPQD---------------------------QTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATW-SLSCFFV--S--------------------------AS--TSPWVA----------CLVATDFYR--------------------------------------------------------------------------------------------------------------------------------------------------
7 | 6tbuA | 0.18 | 0.10 | 3.33 | 1.08 | MapAlign |  | -----------------------------------------------------------RMNWYYHVLA--RRPYL VVVSIAVYCVACIIVALVLNKLPDFSDPTLGF ETRGTKIGERLTAWYNLLQETDHHG---------------------------------------------------------------------------------------------------------------------------ALFSNPSDLWESSPRKEYSHFVVQRIN-ATDSLFDLNGLLAMCQLQDQITEVPSYRAF CEPE---------MLTTECCRPWS LPNYAAMLANKSSCFDLT----TEDVTSLHTLLLG-------------CYEKRLNIVFNVLNFLTDFSFIVYLKYAMIFIPVAQSNRLLPLFHEWEDLINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGS-AFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVV IIG I GAD D V FLFLKIWHCV-LTESLENIMALTMRHAAASMFVT S L T T AGAFYASYSSSITAIKCF GIFAGTVVVTNYLLMITWLP ASVSIMERLFK--------------------------------------------------------------------------------------KSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVPGLQLPEKSHQL FVSKHPFEVYSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKQQFWFEKPYNFKMHMHFVWGVQAVDD---GDYTNPNSYGHLHY DNNF-NVSSRPAQLWILDFCQSQPFYKELPNCFIEFEYCLPQSISNMYDTTFF---------RPGVAGPKFAEPLLVKALVIEF E SNVAYSTIYANIRQFYESVEHWFQMQ LKTA--PPELQGGWFTSDLKFYNVQDTL-SHDTFVAICLAMAASLAVLLCF TVNI LISIYAVLTVSLSIFNTVAVLILLG WQLNILESIAVSTAIGLAV DFSLHYGIHYRMSPV-----------KERLAATQFVLSRIIGPTVMAATT TGLAGGIMMASNILPYIQIGVFLVVVMIV SWFYATFFLMSL LRVAGPQHGFLEL---------------------------------------
8 | 6d4hA | 0.13 | 0.09 | 3.12 | 2.02 | MUSTER |  | -------------------------------------------------P LWLRAKFQLLFKLGCYIQKNCG---KFLVVGLLIFGAFAVGLKAANLETNV---EELWVEVGGRVSRELNYTRQKIGEEAMFNPQPKEEGANLTTEALLQHLDSAL QASRVHVYMYNRQWKLEHYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPAD----------PDCPAT---------------------------APNKNSTKPLDMALVLNGGCHG------LSRKYMHWQEELIVGGTVKNSTGKL---VSAHALQTMFQLMTPKQMYEHFKGY---------EYVSHINWNEDKAAAILEAWQRT Y VEVVHQSVASTQKV LSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRQGAVGLAGVLLVAL SVAAGLGLCSLI-G ISFNAATTQVLPFLALGVG V D D V FLLAHAFSETNKRIPFEDRTGECLKRTGASVALT SISNVTAFFMAALIPI P ALRAFSLQAAVVVVFNFAMV LLIFP AILSMDLYRRED-----------------------------------------------------------------------------------RRTLSSFAEKHYAPFLLK--PKAKVVVIFL FLGLLGVS LYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEE----------------------------------NKQL PKMW---------LHYFRDW-------LQGLQDAFDSDWETGK-------IMPNNYKNGSDDGVLAYKLLLTKQRLVDAD-----------------------------GIINPSAFYIYLTAWVSND------------------------------------------------------------------------PVAYAASQANIRPHRPEWV----------------------HDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRD--------TS DFVEAIEKVRTICSNYTSLGL--SSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCA V FLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSA VPVVILIASV GIGVEFTV HVALAF------------LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFFIVRYFFAVLAILTILGVLNGLVLLPVL LS--------------------------------------------------
9 | 6v3fA | 0.17 | 0.11 | 3.79 | 3.36 | HHsearch |  | QGDTGNGL LDITFHLLEPGQALPDGNGKIAPCNESQDSAVCCQDCAASCPVIPPPALRPSFYMGRM----PGWLALIIIFTAVFVLLSAVLVRLR-----------------V----VS--------------NR N-----KLSPHTILGRFFQNWGTRVASWPLTVLALS--------FIV---------V---IALAAGLT-FIEL-----------TTDPVELWSAP---K--SQ--------ARKEFHDEHFG-------------PFFRTNQI FVTARNRFSGILSLDFLLELLELQERLRHLQSLQDICYAPLNPYNT----SLSDCC-VNS LLQY FQNNRTLLMLTANLNG QSLVDWKDHFLYCANAPLTPFLAVGGYQGT----DYSEEALIITFSLNN YPAD----DPRMAQAKLWEEAFLKEMESFQSDKFQ VAFSAERSLEDEINR TTIQDLPVFAVSYIIVFLYISLALGSKATLGLGGVIVVLGAVLAAMGFYSY-LGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMEQREAHIGRTLGSVAPSMLLCS LSEAICFFLGALTPMP A VRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVL-CKEK--------------------------------------------E--------------------------------GLLLRFFRKIYAPFLLHIRPVVMLL FLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLLNRYLEGPPVYFVTTS GFN---------------------------FSSE AGMNATCSSA---GCK SFSLQKIQY-------------------------ASEFPDQSYV---------------AIAASSWVDDFI------DWLTPS--------SSCCR-L Y-------------------------IRG PHKDEFCPSTDTS----------------FNCLK----------------NCM---N R TL--GPVRP-------TAEQFH-----KYL-------PW--FLNDPPNIRCPKGGL---------------AAYR--------TSVNLSSDGQVIASQFMAYHKPLR--NSQDFTEALRASRLLAANITADVPGTDPNFEVFPYTI--SNVFYQQYLLPEGIFTLALCFVPTFVVCYLLLGDMCSGILNL L S IIMILVDTIGLMAVWGISYNA VSLINLVTAV GMS VEFVSHITRSFAVSTK-----------PTRLERAKDATVFMGSAVFAGAMTNFPGILILGFAQAQLIQIFFFRLNLLILLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLAS--------------------------------
10 | 7k65A | 0.13 | 0.09 | 3.19 | 0.46 | CEthreader |  | ---------------------------------------------------------------------------------------------------FALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYINWNEDRAAAILEAWQRT Y VEVVHQSVASTQKV LPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLSQGAVGLAGVLLVAL SVAAGLGLCSLIG-ISFNAATTQVLPFLALGVG V D D V FLLAHAFSETGQRIPFEDRTGECLKRTGASVALT SISNVTAFFMAALIPI P ALRAFSLQAAVVVVFNFAMV LLIFP AILSMDLYRREDRRTK--------------------------------------------------------------------------------WTLSSFAEKHYAPFLLK--PKAKVVVILL FLGLLGVS LYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNTSLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCA V FLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSA VPVVILIASV GIGVEFTV HVALAFLTAIG------------DKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEDFIVRYFFAVLAILTVLGVLNGLVLLPVL LSFFGPCPEV------------------------------------------
(a) | ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) | ID2 is the number of template residues identical to query divided by query sequence length.
(c) | Cov is equal the number of aligned template residues divided by query sequence length.
(d) | Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) | Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) | Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view | Ranka | Download | Estimated TM-scoreb
| 1 | model1.pdb.gz | 0.4652
(a) | D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) | The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

| Top 10 structural analogs in PDB (as identified by TM-align)
Click to view | Rank | PDB Hit | TM-score | RMSDa | IDENa | Cov. | Download Alignment
--- | --- | --- | --- | --- | --- | --- | ---
| 1 | 6v3fA | 0.74 | 2.45 | 0.119 | 0.766 | model1_6v3fA.pdb.gz
| 2 | 6r4lA | 0.61 | 4.83 | 0.130 | 0.688 | model1_6r4lA.pdb.gz
| 3 | 3jd8A | 0.57 | 4.68 | 0.077 | 0.634 | model1_3jd8A.pdb.gz
| 4 | 7k65A | 0.52 | 4.57 | 0.137 | 0.583 | model1_7k65A.pdb.gz
| 5 | 6ajfA | 0.43 | 4.94 | 0.093 | 0.483 | model1_6ajfA.pdb.gz
| 6 | 6n3tA | 0.42 | 4.58 | 0.097 | 0.469 | model1_6n3tA.pdb.gz
| 7 | 6xe6A | 0.42 | 5.22 | 0.139 | 0.479 | model1_6xe6A.pdb.gz
| 8 | 2j8sA | 0.42 | 6.00 | 0.091 | 0.494 | model1_2j8sA.pdb.gz
| 9 | 6wu0B | 0.42 | 4.68 | 0.099 | 0.466 | model1_6wu0B.pdb.gz
| 10 | 6tbuA | 0.41 | 5.08 | 0.143 | 0.469 | model1_6tbuA.pdb.gz
(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)
GO term | CscoreGO | Name
GO:0005215 | 0.61 | transporter activity
Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Biological Process (BP)

GO term | CscoreGO | Name
GO:0065007 | 0.91 | biological regulation
GO:0050789 | 0.83 | regulation of biological process
GO:0050794 | 0.82 | regulation of cellular process
GO:0048519 | 0.71 | negative regulation of biological process
GO:0048523 | 0.70 | negative regulation of cellular process
GO:0051239 | 0.69 | regulation of multicellular organismal process
GO:0050793 | 0.69 | regulation of developmental process
GO:0048518 | 0.68 | positive regulation of biological process
GO:2000026 | 0.67 | regulation of multicellular organismal development
GO:0080090 | 0.66 | regulation of primary metabolic process
GO:0051241 | 0.66 | negative regulation of multicellular organismal process
GO:0051093 | 0.66 | negative regulation of developmental process
GO:0045595 | 0.65 | regulation of cell differentiation
GO:0048522 | 0.64 | positive regulation of cellular process
GO:0009987 | 0.64 | cellular process
GO:0045596 | 0.63 | negative regulation of cell differentiation
GO:0009893 | 0.63 | positive regulation of metabolic process
GO:0045664 | 0.62 | regulation of neuron differentiation
GO:0042127 | 0.62 | regulation of cell proliferation
GO:2000179 | 0.61 | positive regulation of neural precursor cell proliferation
GO:0045834 | 0.61 | positive regulation of lipid metabolic process
GO:0045665 | 0.61 | negative regulation of neuron differentiation
GO:0044699 | 0.56 | single-organism process
GO:0065008 | 0.55 | regulation of biological quality
GO:0048878 | 0.54 | chemical homeostasis
GO:0042632 | 0.53 | cholesterol homeostasis
GO:0008152 | 0.50 | metabolic process

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Cellular Component (CC)

GO term | CscoreGO | Name
GO:0044464 | 0.99 | cell part
GO:0044424 | 0.96 | intracellular part
GO:0043229 | 0.78 | intracellular organelle
GO:0043231 | 0.75 | intracellular membrane-bounded organelle
GO:0044425 | 0.72 | membrane part
GO:0016020 | 0.72 | membrane
GO:0044444 | 0.71 | cytoplasmic part
GO:0044422 | 0.70 | organelle part
GO:0044446 | 0.68 | intracellular organelle part
GO:0016021 | 0.68 | integral component of membrane
GO:0044428 | 0.61 | nuclear part
GO:0005783 | 0.60 | endoplasmic reticulum
GO:0031090 | 0.56 | organelle membrane
GO:0005737 | 0.51 | cytoplasm

Download full result of the above consensus prediction.

| Click the graph to show a high resolution version.
(a) | CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) | The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
[0.4,0.5) | [0.5,0.6) | [0.6,0.7) | [0.7,0.8) | [0.8,0.9) | [0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

| Top 5 enzyme homologs in PDB
Click to view | Rank | CscoreEC | PDB Hit | TM-score | RMSDa | IDENa | Cov. | EC Number | Predicted Active Site Residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 0.060 | 3dy5A | 0.209 | 9.02 | 0.034 | 0.306 | 1.13.11.40 4.2.1.92 | NA
| 2 | 0.060 | 2cseW | 0.209 | 10.03 | 0.034 | 0.329 | 3.6.4.13 | NA
| 3 | 0.060 | 2pffD | 0.229 | 9.49 | 0.035 | 0.339 | 2.3.1.86 | NA
| 4 | 0.060 | 3ixzA | 0.235 | 8.19 | 0.027 | 0.319 | 3.6.3.10 | NA
| 5 | 0.060 | 3b8eA | 0.233 | 7.85 | 0.034 | 0.312 | 3.6.3.9 | NA
| Click on the radio buttons to visualize predicted active site residues.
(a) | CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) | TM-score is a measure of global structural similarity between query and template protein.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

| Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
No Binding sites was predicted
| Click on the radio buttons to visualize predicted binding site and residues.
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) | TM-score is a measure of global structural similarity between query and template protein.
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e) | IDENa is the percentage sequence identity in the structurally aligned region.
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

#### [Click result.zip to download all results on this page]

References:
1. | Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.