D-I-TASSER Q9WJR5-D1

D-I-TASSER results for Q9WJR5-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>Q9WJR5 (560 residues)
NKSKKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVNAVIQPMGPLQPGLPSLAMIPKDWP
LIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVG
RALQPVREKFSDCYIIHYIDDILCAAEMKDKLIDCYTFLQAEVANAGLAIASDKIQTSTP
FHYLEMQIENRKIKPPKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILR
GDSDLNSKRMLTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTD
LVEWSFLPHSTVKTFTLYLDQMATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINS
GAWQIGLANFVGIIDNHYPKTKIFQFLKMTNSPHEGKLIWWKDNKNKTWEIGKVITWGRG
FACVSPGENQLPVWIPTRHLKFYNEPIGDAKKSTSAETETPQSSTVDSQDEQNGDVRRTD
EVAIHQESRAADLGTTKEAD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| NKSKKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVNAVIQPMGPLQPGLPSLAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVREKFSDCYIIHYIDDILCAAEMKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLEMQIENRKIKPPKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRMLTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKTFTLYLDQMATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKMTNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWIPTRHLKFYNEPIGDAKKSTSAETETPQSSTVDSQDEQNGDVRRTDEVAIHQESRAADLGTTKEAD
Prediction	CCCCCCCCCHHHHCSSSSCCCCCCCCCCCCCCCCCSCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCSSSSSCCCCCSHHHHHHHHHHHHCCCCCCCSCCCCCCCCCCCCCCCCCSSSSSCCCSSSSCCCCCCCCCCCSCCCCCCCCCCCCCCSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCSSSSSSCCCSSSCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCSSCCSSCCCCCSSCCSSCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCSSSSSSSCCCCCSSSSSSCCCCCSSSCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCSSSSCCSHHHHHHHHHHCCHHHHHHCCCCCCSSSSCCCHHHHHHHHCCCCCCCCCSSSSSCCCCCCCCCSSSSSCCCCSSCCCCCCCCSSSSSHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
Confidence	97667541134425056257777774124579861104889389999999999999980898999999989658997179950333438988620356677613458999934367897258997045334167992224330113566688999720342256888889735778999999999998799749998413026547970889999999999999928999863235799742010156388324576447888876579999986368878777527852589999997299887774148999999999999999986442258999837998616998469999759974122125666756784799999999999988853337788889946627799999861511344324588707984393689999860368879963899779987643227987486012136776521121107788874366321223422344235787612330124554333333410121111257666689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| NKSKKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVNAVIQPMGPLQPGLPSLAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVREKFSDCYIIHYIDDILCAAEMKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLEMQIENRKIKPPKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRMLTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKTFTLYLDQMATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKMTNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWIPTRHLKFYNEPIGDAKKSTSAETETPQSSTVDSQDEQNGDVRRTDEVAIHQESRAADLGTTKEAD
Prediction	85564423000302010101135151343635342042021345215003400530176361552711100000001146430100100130043044433010001100000014561200000011000000024721510000000301621131000100001011000000100020031026420100000000000000414630350053015101610041056121651001000100226404114050446423000200100131000000032354403300310323541543140055044005403520452212313362301010124362000000136421111122233442021303000200220031001100130320200043410330123131010010011020120212410320040363216402010010443514202012325423334523230100013300530251143136423253315434534355365552445643323454313424445658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of DeepPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCCCCCCCHHHHCSSSSCCCCCCCCCCCCCCCCCSCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCSSSSSCCCCCSHHHHHHHHHHHHCCCCCCCSCCCCCCCCCCCCCCCCCSSSSSCCCSSSSCCCCCCCCCCCSCCCCCCCCCCCCCCSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCSSSSSSCCCSSSCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCSSCCSSCCCCCSSCCSSCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCSSSSSSSCCCCCSSSSSSCCCCCSSSCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCSSSSCCSHHHHHHHHHHCCHHHHHHCCCCCCSSSSCCCHHHHHHHHCCCCCCCCCSSSSSCCCCCCCCCSSSSSCCCCSSCCCCCCCCSSSSSHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
NKSKKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVNAVIQPMGPLQPGLPSLAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVREKFSDCYIIHYIDDILCAAEMKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLEMQIENRKIKPPKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRMLTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKTFTLYLDQMATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKMTNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWIPTRHLKFYNEPIGDAKKSTSAETETPQSSTVDSQDEQNGDVRRTDEVAIHQESRAADLGTTKEAD

6uebA

0.08

0.05

2.14

0.83

DEthreader

---------------------------ESMDPILKSHSFWLNRGGPV------------------PDEDLIIGLKPKERKIEGRFFALMSWLRLYFVITELLYILPLFDAKLIDRVTQTYAFHLDYEKWNNHQRLEHEFFQKAWIYYSSDLIGLREQIYWNGQDGGLELRQKGWSLVSLLMIDRESQIRNTRTKILAQGDNQVLCPTYISNALSIYRAVEEGASKLGLIIKKEETMCSDFLIYGKTPLFRGNILVPESKRWARVSCV-VNLANIMSTVSTAL-LIMRDFLLMSVQAVFHYLLFSLGRVY-L----------M---I----------------DPSLGGISGMSGRFHIR-QFSDPVGLAPDLG-RLES-TRLLE-D-------------------P-TTLNI-GASTILKI-PRFLSEL---SE-ADLRERKVVGT---RALSLKESINWFI------RDSNLAQALIRNIMAPVKTDVTLETSQIFEF--PDVS-------------------------------------------------------

3drrA

0.24

0.22

6.96

2.51

SPARKS-K

---------------SPISPIETVPVKLKPMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKPENPYNTPVFAIKKKDSKWRKLVDFRELNKRT---QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIK--VRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVGVYYDPSKDLIAEIQKQGQGQTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTP-KFKLPIQKETWETWWTEQATWIP-------EWEFVNTPPLVKLWYQLEKEPIVGAETFYVDRETKLGKAGYVTNRGRQKVVTLTSGLEVNIVTDLGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIR---------

5ovnA

0.22

0.20

6.26

1.95

MapAlign

----------------------------------------LTNEKIEALTEIVERLEREGKVKRADNPWNTPVFAIKKKSGKWRMLIDFREL-----NKLTEKGAQLGLPHPAGLQIKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKNNAGPGRRFVWCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLKKEHKEKVEELRKLLLWWGFETPEDKLQEEPPYTWMGYELHPLTWTIQQKQLDIPEQPTLNELQKLAGKINWASQAIPDL--SIKALTNMMRGNQNLNSTRQWTKEARLEVQKAKKAIEQVQLGYYDPSKELYAKLSLVPHQISYQVYQKDPEKILWYGKMSRQKKAENTCDIALRACYKIREESIIRIGK-EPRYEIPTSREAWESLINSPYLKAPPPEVEYIHAALNIKRALSMIKDAPIPGAETWYIDGGRKL--GKAAKAAYWTDTGKWQVMELEGSNQKAEIQALLLALKAGSEEMNIITDSQYVINIILQQPDMMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGN

5ovnA

0.25

0.22

6.88

1.16

CEthreader

----------------------------------QIKQWPLTNEKIEALTEIVERLEREGKVKRPNNPWNTPVFAIKKKSGKWRMLIDFRELNKLTEK-----GAQLGLPHPAGLQIKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKNNAGPGRRFVWCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLKKEHKEKVEELRKLLLWWGFETPEDKLQEEPPYTWMGYELHPLTWTIQQKQLDIPEQPTLNELQKLAGKINWASQAI--PDLSIKALTNMMRGNQNLNSTRQWTKEARLEVQKAKKAIEEQVQGYYDPSKELYAKLSLGPHQISYQVYQKDPEILWYGKMSRQKKKAENTCDIALRACYKIREESIIRIGKEP-RYEIPTSREAWESNLINSPAALNIKRALSMIKDAPIPGAETWYIDGGRKLGKAAKAAYWTDTGKWQVMELEGSNQKAEIQALLLALKAMNIITDSQYVINIILQQPDMMEGIWQEVLE--------------ELEKKTAIFIDWVPGHKGIPGNEEVD

3drrA

0.26

0.24

7.54

1.87

MUSTER

---------------SPISPIETVPVKLKPGDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKPENPYNTPVFAIKKKSTKWRKLVDFRELNKR---TQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQI--YPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEVHGVYYDPSKDLIAEIQKQGQGQTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTP-KFKLPIQKETWETWWTE--YWQ---ATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDRETKLGKAGYVTNRGRQKVVTLTD--TTNQKT-YLALQDSGLEVTDSQ-GIIQAQPDQSESELVNQ-EQ---LIKKEKVYLAW--PA-GIGGNEQVD

3drrA

0.25

0.23

7.27

4.62

HHsearch

---------------SPISPIETVPVKLKPMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKPENPYNTPVFAIKKKDSTWRKLVDFRELNKR--T-QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIK--VRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYDPSKDLIAEIQKQGQGQTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPK-FKLPIQKETWETWWT--EYWQATWI---PEWEFVNT-PPLVKLYQLEKEPIVGAETFYVDGAANRGKAGYVTNRGRQKVVTTDTTNQKTEQAIYLALQDSGLEVNIVTDSQYAIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVD

3drrA

0.26

0.24

7.39

2.72

FFAS-3D

------------------SPISPIETVPVKLKPGMVKQWPLTEEKIKALVEICTEMEKEGKISKPENPYNTPVFAIKKKDSKWRKLVDFRELNKRT---QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGI--KVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEVHGVYYDPSKDLIAEIQKQGQGQTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLW------YQLEKEPIVGAETFYVDRETKLGKAGYVTNRGRQKVVTLTDTTGLEVNIVT-----------DSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVD

1mu2A

0.18

0.16

5.27

1.63

EigenThreader

-----------------AKVEPIKIMLKPGKDGPKLRQWPLTKEKIEALKEICEKMEKEGQLEPPTNPYNTPTFAI--KKKDRMLIDF-RELNKVTQDFTEIQLGIPHP---AGLAKKRRITVLDVYFSIPLHEDFRPYTA--FTLK----------RYIYKVLPQGWKGSPAIFQHTMRQVLEPFRKANKDVIIIQYMDDILASDRTDLEHDRVVLQLKELLNGLGFSTPDEKFQKDPPYHWMGYELWPTKWKLQKIQLPQKEIWTVNDIQKLVGVLNWAAQLYPGI-----KTKHLCRLIMTLTEEVQWTELAEAELEENRIILSQEQEGHYYQKELEATVQKDQDNQ-WTYKIHQE---EGKYAKVTHGIRLLAQVVQKIGKEALVIWG-------RIPKFHLPVEREIWEQWWDNYWQVTW---IPDWDFVSTPPLVRLAFNLVGDPIPGAETFYTDGSRQSKEGKAGYVTDLEQTEAFAMALTDSGPKVNIIVDSQYVMGIVASQPTSKIVNQIIEEMIKKEPAHKGIGG--------NQEVDHLVSQGI-----

5xn0A

0.26

0.21

6.44

3.24

CNFpred

-----------------------VPVKLKPMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGNPYNTPVFAIKKKSTKWRKLVDFRELNKR---TQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGI--KVRQLSKLLRGTKALTEVVPLTEEAELELAENREILKEPVHGYYDPSKDLIAEIQKQGQGQWTYQIYQEFKNLKTGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGK-TPKFKLPIQKETWEAWWTE--YWQATWIP---EWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAAKLGKAGYVTDRGRQKVVP----------------------------------------------------------------------------

5a22A

0.07

0.04

1.88

0.83

DEthreader

----------------------------DLLDPIYSHSMEVHVMNPNTPI---------------LDDDDLIIGLKGKELAGRFFSLMSWKLREYFVITELIHFVPMFKGKMLDSSSGCIANHIDYEKWNNHQRKL-RHEFFEKSLIYPD--RVHNNTLWQGQEGGLELRQKGWTILNLLVIQREAKIRNTAVKVLAQGDNQVICTQYLNMVSNNEKIMTAIKIGTGLLINDDETMQSDYLNYGKIPIFRGVIRGLEKRWSRVTCVIPTCANIMSSVSTALA-PIMIQYNYGTFARLLLMMHDLRQSLYE-----------Y--LY----------------DPSIGGVSGMSSRFLIR--AFPDPSLFPEIAMGMSPANL-------------------------------PLFPRFLSEFKSGT------AT-ADRYRTVIGTT---RATRLRDAISWFV------DSKLAMLSIHSLTRQHFKRTEITLDSSMDYTP-P-V--------------------------------------------------------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.6458

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of DeepPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	3drrA	0.88	2.61	0.242	0.950	model1_3drrA.pdb.gz
2	1mu2A	0.77	3.44	0.213	0.855	model1_1mu2A.pdb.gz
3	5ovnA	0.74	4.53	0.180	0.895	model1_5ovnA.pdb.gz
4	1rw3A	0.64	3.57	0.159	0.736	model1_1rw3A.pdb.gz
5	4ol8A	0.58	3.20	0.172	0.654	model1_4ol8A.pdb.gz
6	3ig1B	0.33	5.13	0.120	0.438	model1_3ig1B.pdb.gz
7	2fm1D	0.19	6.99	0.013	0.293	model1_2fm1D.pdb.gz
8	1st0A	0.17	6.03	0.037	0.243	model1_1st0A.pdb.gz
9	3h7nA2	0.17	6.53	0.083	0.248	model1_3h7nA2.pdb.gz
10	1goaA	0.16	3.65	0.041	0.180	model1_1goaA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0003824	0.72	catalytic activity
GO:0003964	0.61	RNA-directed DNA polymerase activity
GO:0004518	0.60	nuclease activity
GO:0004540	0.59	ribonuclease activity
GO:0008233	0.58	peptidase activity
GO:0004523	0.55	RNA-DNA hybrid ribonuclease activity
GO:0042802	0.52	identical protein binding
GO:0008289	0.51	lipid binding
GO:0003887	0.50	DNA-directed DNA polymerase activity
GO:0003723	0.50	RNA binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0009987	1.00	cellular process
GO:0006259	0.90	DNA metabolic process
GO:0039663	0.71	membrane fusion involved in viral entry into host cell
GO:0075713	0.69	establishment of integrated proviral latency
GO:0006278	0.69	RNA-dependent DNA biosynthetic process
GO:0051701	0.67	interaction with host
GO:0051169	0.67	nuclear transport
GO:0019068	0.59	virion assembly
GO:0006310	0.57	DNA recombination

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044464	1.00	cell part
GO:0044424	0.96	intracellular part
GO:0044428	0.77	nuclear part
GO:0016020	0.70	membrane
GO:0005829	0.60	cytosol
GO:0005654	0.53	nucleoplasm
GO:0005886	0.51	plasma membrane
GO:0005634	0.51	nucleus
GO:0005576	0.51	extracellular region

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.149	1mu2A	0.771	3.44	0.213	0.855	3.4.23.47	NA
2	0.119	1rw3A	0.645	3.57	0.159	0.736	2.7.7.49	52
3	0.060	2hixA	0.349	7.55	0.061	0.561	6.5.1.1	NA
4	0.060	3c6tA	0.879	2.64	0.238	0.952	2.7.7.49 2.7.7.7	NA
5	0.060	2r7oA	0.421	7.00	0.049	0.625	2.7.7.48	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Click to view	Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
	1	0.28	1r0aA	0.880	2.49	0.234	0.946	0.66	QNA	complex1.pdb.gz	39,45,74,76,77,86,87,88,90,93,104,106,108,109,166,167,169,172,279
	2	0.05	3kleA	0.860	2.97	0.232	0.948	0.63	ZP4	complex2.pdb.gz	125,126,127,128,129,130,131,166,200,229,231,233

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Click result.zip to download all results on this page]

References:
1.	Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Yiheng Zhu, P. Lydia Freddolino, Yang Zhang. Integrating deep learning potentials with I-TASSER for single- and multi-domain protein structure prediction. Submitted. 2023.