1pl0/2/1:D/1:C

Sequences
>1pl0-a2-m1-cD (length=579) [Search sequence]
GQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGG
RVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQ
IDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTA
QYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDA
LNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAY
ARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYC
VLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATI
AVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMISNAIDQ
YVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKR
SGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
>1pl0-a2-m1-cC (length=585) [Search sequence]
QLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGR
VKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQI
DIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQ
YDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDAL
NAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYA
RARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCV
LQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIA
VKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGAEI
SNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDN
VDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
Structure information
PDB ID 1pl0 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC
Assembly ID 2
Resolution 2.6Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 380
Sequence identity between the two chains 0.998
PubMed citation 14966129
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID D C
UniProt accession P31939 P31939
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:1pl0D BioLiP:1pl0C
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 1pl0-a2-m1-cD_1pl0-a2-m1-cC.pdb.gz
Full biological assembly
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Download: 1pl0-assembly2.cif.gz
Similar dimers
Other dimers with similar sequences and structures 1p4r/1/1:B/1:A 1pkx/1/1:A/1:B 1pkx/2/1:C/1:D 1pl0/1/1:B/1:A 5uy8/1/1:A/1:B 5uy8/2/1:C/1:D 5uz0/1/1:A/1:B 5uz0/2/1:D/1:C

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