2cw6/4/4:F/2:B |
| >2cw6-a4-m4-cF (length=288) [Search sequence] |
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNCSIEESFQR
FDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVG
TPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGASGN
LATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC |
| >2cw6-a4-m2-cB (length=296) [Search sequence] |
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF
QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC |
|
| PDB ID |
2cw6 (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria |
| Assembly ID |
4 |
| Resolution |
2.1Å |
| Method of structure determination |
X-RAY DIFFRACTION |
| Number of inter-chain contacts |
24 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
16330550 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
4 |
2 |
| Chain ID |
F |
B |
| UniProt accession |
P35914 |
P35914 |
| Species |
9606 (Homo sapiens) |
9606 (Homo sapiens) |
| Function annotation |
BioLiP:2cw6F |
BioLiP:2cw6B |
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Switch viewer: [NGL] [JSmol]
|
Dimer structure:
Chain 1 in red;
Chain 2 in blue.
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Full biological assembly
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| Other dimers with similar sequences and structures |
2cw6/4/1:C/4:C 2cw6/4/1:D/4:D 2cw6/4/1:E/3:A 2cw6/4/1:F/3:B 2cw6/4/2:A/4:E |
| Other dimers with similar sequences but different poses |
2cw6/5/2:A/2:B 2cw6/1/1:A/1:B 2cw6/2/1:D/1:C 2cw6/3/1:F/1:E 2cw6/4/1:D/1:C 2cw6/4/1:F/1:E 2cw6/4/2:A/2:B 2cw6/4/3:A/3:B 2cw6/4/4:D/4:C 2cw6/4/4:F/4:E 2cw6/5/1:D/1:C 2cw6/5/1:F/1:E 3mp3/1/1:A/1:B 3mp3/2/1:D/1:C 3mp3/3/1:E/1:F 3mp4/1/1:A/1:B 3mp4/2/1:C/1:D 3mp4/3/1:F/1:E 3mp5/1/1:A/1:B 3mp5/2/1:C/1:D 3mp5/3/1:F/1:E
2cw6/5/1:C/2:A 2cw6/4/1:C/1:E 2cw6/4/1:C/2:A 2cw6/4/4:C/3:A 2cw6/4/4:C/4:E 2cw6/5/1:C/1:E |
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