2cw6/5/1:C/2:A

Sequences
>2cw6-a5-m1-cC (length=294) [Search sequence]
LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH
TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ
RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV
GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY
AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQAT
>2cw6-a5-m2-cA (length=296) [Search sequence]
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF
QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC
Structure information
PDB ID 2cw6 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria
Assembly ID 5
Resolution 2.1Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 31
Sequence identity between the two chains 1.0
PubMed citation 16330550
Chain information
Chain 1 Chain 2
Model ID 1 2
Chain ID C A
UniProt accession P35914 P35914
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:2cw6C BioLiP:2cw6A
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
Download: 2cw6-a5-m1-cC_2cw6-a5-m2-cA.pdb.gz
Full biological assembly
Download: 2cw6-assembly5.cif.gz
Similar dimers
Other dimers with similar sequences and structures 2cw6/4/1:C/1:E 2cw6/4/1:C/2:A 2cw6/4/4:C/3:A 2cw6/4/4:C/4:E 2cw6/5/1:C/1:E
Other dimers with similar sequences but different poses
  • 2cw6/5/2:A/2:B 2cw6/1/1:A/1:B 2cw6/2/1:D/1:C 2cw6/3/1:F/1:E 2cw6/4/1:D/1:C 2cw6/4/1:F/1:E 2cw6/4/2:A/2:B 2cw6/4/3:A/3:B 2cw6/4/4:D/4:C 2cw6/4/4:F/4:E 2cw6/5/1:D/1:C 2cw6/5/1:F/1:E 3mp3/1/1:A/1:B 3mp3/2/1:D/1:C 3mp3/3/1:E/1:F 3mp4/1/1:A/1:B 3mp4/2/1:C/1:D 3mp4/3/1:F/1:E 3mp5/1/1:A/1:B 3mp5/2/1:C/1:D 3mp5/3/1:F/1:E
  • 2cw6/4/4:F/2:B 2cw6/4/1:C/4:C 2cw6/4/1:D/4:D 2cw6/4/1:E/3:A 2cw6/4/1:F/3:B 2cw6/4/2:A/4:E
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