2ewy/6/1:C/1:D

Sequences

>2ewy-a6-m1-cC (length=374) [Search sequence]

LAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGIL GLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGANGGSLVLGGIEPSLYKGDIWYT PIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARA SLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMG AGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISG PFSTEDVASNCVPA

>2ewy-a6-m1-cD (length=374) [Search sequence]

LAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGIL GLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGANGGSLVLGGIEPSLYKGDIWYT PIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARA SLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMG AGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISG PFSTEDVASNCVPA

Structure information

PDB ID	2ewy (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor
Assembly ID	6
Resolution	3.1Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	80
Sequence identity between the two chains	1.0
PubMed citation	16305800

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	C	D
UniProt accession	Q9Y5Z0	Q9Y5Z0
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:2ewyC	BioLiP:2ewyD

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Download: 2ewy-a6-m1-cC_2ewy-a6-m1-cD.pdb.gz

Full biological assembly Download: 2ewy-assembly6.cif.gz

Similar dimers

Other dimers with similar sequences and structures

2ewy/5/1:A/1:B 3zlq/1/1:A/1:B