2q6c/1/1:C/1:B |
| >2q6c-a1-m1-cC (length=414) [Search sequence] |
PNEECLQILGNGAKFLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQLLSKKLSEP
SSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVAST
NRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTS
RFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGN
YCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSI
GGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVG
GGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG |
| >2q6c-a1-m1-cB (length=420) [Search sequence] |
EPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQLLS
KKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEG
CLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKE
AFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQI
LAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGS
AMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSI
EIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG |
|
| PDB ID |
2q6c (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors |
| Assembly ID |
1 |
| Resolution |
2Å |
| Method of structure determination |
X-RAY DIFFRACTION |
| Number of inter-chain contacts |
90 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
17574411 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
1 |
1 |
| Chain ID |
C |
B |
| UniProt accession |
P04035 |
P04035 |
| Species |
9606 (Homo sapiens) |
9606 (Homo sapiens) |
| Function annotation |
BioLiP:2q6cC |
BioLiP:2q6cB |
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Switch viewer: [NGL] [JSmol]
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Dimer structure:
Chain 1 in red;
Chain 2 in blue.
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Full biological assembly
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| Other dimers with similar sequences and structures |
1dq8/1/1:C/1:B 1dq8/1/1:D/1:A 1dq9/1/1:A/1:D 1dq9/1/1:B/1:C 1dqa/1/1:C/1:B 1dqa/1/1:D/1:A 1hw8/1/1:C/1:B 1hw8/1/1:D/1:A 1hw9/1/1:C/1:B 1hw9/1/1:D/1:A 1hwi/1/1:C/1:B 1hwi/1/1:D/1:A 1hwj/1/1:B/1:C 1hwj/1/1:D/1:A 1hwk/1/1:B/1:C 1hwk/1/1:D/1:A 1hwl/1/1:B/1:C 1hwl/1/1:D/1:A 2q1l/1/1:A/1:D 2q1l/1/1:B/1:C 2q6b/1/1:C/1:B 2q6b/1/1:D/1:A 2q6c/1/1:D/1:A 2r4f/1/1:C/1:B 2r4f/1/1:D/1:A 3bgl/1/1:C/1:B 3bgl/1/1:D/1:A 3cct/1/1:C/1:B 3cct/1/1:D/1:A 3ccw/1/1:C/1:B 3ccw/1/1:D/1:A 3ccz/1/1:C/1:B 3ccz/1/1:D/1:A 3cd0/1/1:C/1:B 3cd0/1/1:D/1:A 3cd5/1/1:C/1:B 3cd5/1/1:D/1:A 3cd7/1/1:A/1:D 3cd7/1/1:B/1:C 3cda/1/1:C/1:B 3cda/1/1:D/1:A 3cdb/1/1:C/1:B 3cdb/1/1:D/1:A |
| Other dimers with similar sequences but different poses |
1hw8/1/1:D/1:C 1dq8/1/1:B/1:A 1dq8/1/1:C/1:D 1dq9/1/1:A/1:B 1dq9/1/1:C/1:D 1dqa/1/1:B/1:A 1dqa/1/1:D/1:C 1hw8/1/1:A/1:B 1hw9/1/1:B/1:A 1hw9/1/1:D/1:C 1hwi/1/1:A/1:B 1hwi/1/1:C/1:D 1hwj/1/1:B/1:A 1hwj/1/1:D/1:C 1hwk/1/1:B/1:A 1hwk/1/1:D/1:C 1hwl/1/1:B/1:A 1hwl/1/1:D/1:C 2q1l/1/1:A/1:B 2q1l/1/1:D/1:C 2q6b/1/1:B/1:A 2q6b/1/1:D/1:C 2q6c/1/1:B/1:A 2q6c/1/1:D/1:C 2r4f/1/1:B/1:A 2r4f/1/1:D/1:C 3bgl/1/1:A/1:B 3bgl/1/1:D/1:C 3cct/1/1:A/1:B 3cct/1/1:D/1:C 3ccw/1/1:A/1:B 3ccw/1/1:D/1:C 3ccz/1/1:B/1:A 3ccz/1/1:D/1:C 3cd0/1/1:A/1:B 3cd0/1/1:D/1:C 3cd5/1/1:A/1:B 3cd5/1/1:D/1:C 3cd7/1/1:A/1:B 3cd7/1/1:D/1:C 3cda/1/1:B/1:A 3cda/1/1:D/1:C 3cdb/1/1:A/1:B 3cdb/1/1:D/1:C
1hwi/1/1:D/1:B 1dq8/1/1:B/1:D 1dq8/1/1:C/1:A 1dq9/1/1:A/1:C 1dq9/1/1:B/1:D 1dqa/1/1:C/1:A 1dqa/1/1:D/1:B 1hw8/1/1:C/1:A 1hw8/1/1:D/1:B 1hw9/1/1:C/1:A 1hw9/1/1:D/1:B 1hwi/1/1:C/1:A 1hwj/1/1:C/1:A 1hwj/1/1:D/1:B 1hwk/1/1:C/1:A 1hwk/1/1:D/1:B 1hwl/1/1:C/1:A 1hwl/1/1:D/1:B 2q1l/1/1:A/1:C 2q1l/1/1:D/1:B 2q6b/1/1:C/1:A 2q6b/1/1:D/1:B 2q6c/1/1:C/1:A 2q6c/1/1:D/1:B 2r4f/1/1:C/1:A 2r4f/1/1:D/1:B 3bgl/1/1:C/1:A 3bgl/1/1:D/1:B 3cct/1/1:C/1:A 3cct/1/1:D/1:B 3ccw/1/1:C/1:A 3ccw/1/1:D/1:B 3ccz/1/1:C/1:A 3ccz/1/1:D/1:B 3cd0/1/1:C/1:A 3cd0/1/1:D/1:B 3cd5/1/1:C/1:A 3cd5/1/1:D/1:B 3cd7/1/1:A/1:C 3cd7/1/1:D/1:B 3cda/1/1:C/1:A 3cda/1/1:D/1:B 3cdb/1/1:C/1:A 3cdb/1/1:D/1:B |
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