3irm/2/1:D/1:C

Sequences
>3irm-a2-m1-cD (length=513) [Search sequence]
LFKIRMPETVAEGTRLALRAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGK
NVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHA
DSIVAVNGGLEQALRLLASPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRA
SESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYLS
LVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRG
ETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDANYD
GQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNGELSCMLYQ
RSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRVPR
AFPYLVFRREREFLEDYEEGDMEVIDYAPYPPI
>3irm-a2-m1-cC (length=516) [Search sequence]
SLFKIRMPETVAEGTRLALRAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRG
KNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLH
ADSIVAVNGGLEQALRLLASPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIR
ASESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYL
SLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLR
GETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDANY
DGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNGELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRVP
RAFPYLVFRREREFLEDYEEGDMEVIDYAPYPPISM
Structure information
PDB ID 3irm (database links: RCSB PDB PDBe PDBj PDBsum)
Title Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil
Assembly ID 2
Resolution 2.1Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 98
Sequence identity between the two chains 1.0
PubMed citation
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID D C
UniProt accession Q27793 Q27793
Species 5693 (Trypanosoma cruzi) 5693 (Trypanosoma cruzi)
Function annotation BioLiP:3irmD BioLiP:3irmC
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 3irm-a2-m1-cD_3irm-a2-m1-cC.pdb.gz
Full biological assembly
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Download: 3irm-assembly2.cif.gz
Similar dimers
Other dimers with similar sequences and structures 2h2q/2/2:B/1:A 3cl9/1/1:A/2:A 3cl9/3/1:A/2:A 3cl9/3/3:A/4:A 3clb/1/1:D/1:A 3clb/2/1:B/1:C 3hbb/1/1:D/1:A 3hbb/2/1:B/1:C 3inv/1/1:B/1:A 3irm/1/1:B/1:A 3irn/1/1:A/1:B 3irn/2/1:D/1:C 3iro/1/1:B/1:A 3iro/2/1:D/1:C 3kjs/1/1:A/1:D 3kjs/2/1:B/1:C 5t7o/1/1:A/1:B 5t7o/2/1:C/1:D
Other dimers with similar sequences but different poses
  • 3cl9/3/1:A/4:A 2h2q/1/1:B/1:A 3cl9/3/2:A/3:A
  • 3cl9/3/2:A/4:A 3cl9/2/1:A/3:A 3cl9/3/1:A/3:A
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