3l95/2/1:Y/1:X

Sequences
>3l95-a2-m1-cY (length=215) [Search sequence]
NKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGF
DCQGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPP
EQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYYGDVRGSIVYLEIDNRQCVQASS
QCFQSATDVAAFLGALASLGSLNIPYKIEAVQSET
>3l95-a2-m1-cX (length=230) [Search sequence]
GSACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHC
DSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHV
PERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYYGDVRG
SIVYLEIDNRQCVSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETV
Structure information
PDB ID 3l95 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody
Assembly ID 2
Resolution 2.19Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 36
Sequence identity between the two chains 0.986
PubMed citation 20393564
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID Y X
UniProt accession P46531 P46531
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:3l95Y BioLiP:3l95X
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
Download: 3l95-a2-m1-cY_3l95-a2-m1-cX.pdb.gz
Full biological assembly
Download: 3l95-assembly2.cif.gz
Similar dimers
Other dimers with similar sequences and structures 3i08/3/1:A/2:C 3l95/1/1:Y/1:X

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