3tik/1/1:A/1:B

Sequences

>3tik-a1-m1-cA (length=450) [Search sequence]

KGKLPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHS
RFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ
HEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESS
LIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLS
AVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFP
AQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLS
HHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL
LRDEVPDPDYHTMVVGPTASQCRVKYIRRK

>3tik-a1-m1-cB (length=450) [Search sequence]

Structure information

PDB ID	3tik (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one
Assembly ID	1
Resolution	2.05Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	47
Sequence identity between the two chains	1.0
PubMed citation	22777048

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	A	B
UniProt accession	Q385E8	Q385E8
Species	5691 (Trypanosoma brucei)	5691 (Trypanosoma brucei)
Function annotation	BioLiP:3tikA	BioLiP:3tikB

3D structure

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Dimer structure: Chain 1 in red; Chain 2 in blue.

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Download:	3tik-a1-m1-cA_3tik-a1-m1-cB.pdb.gz

Full biological assembly

Download:

3tik-assembly1.cif.gz