3tik/3/1:B/1:C

Sequences

>3tik-a3-m1-cB (length=450) [Search sequence]

KGKLPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHS
RFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ
HEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESS
LIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLS
AVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFP
AQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLS
HHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL
LRDEVPDPDYHTMVVGPTASQCRVKYIRRK

>3tik-a3-m1-cC (length=450) [Search sequence]

Structure information

PDB ID	3tik (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one
Assembly ID	3
Resolution	2.05Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	64
Sequence identity between the two chains	1.0
PubMed citation	22777048

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	B	C
UniProt accession	Q385E8	Q385E8
Species	5691 (Trypanosoma brucei)	5691 (Trypanosoma brucei)
Function annotation	BioLiP:3tikB	BioLiP:3tikC

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

3tik-a3-m1-cB_3tik-a3-m1-cC.pdb.gz

Full biological assembly

Download:

3tik-assembly3.cif.gz

Similar dimers

Other dimers with similar sequences and structures	3tik/1/1:A/1:D 3tik/1/1:B/1:C 3tik/2/1:A/1:D
Other dimers with similar sequences but different poses	2x2n/2/1:C/1:A 2x2n/1/1:B/1:D