4c0c/1/2:A/3:A

Sequences

>4c0c-a1-m2-cA (length=446) [Search sequence]

GKLPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSR
FFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQH
EVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSL
IPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASTSDLLGGLLKAVYRD
GTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNY
DNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEE
AFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEV
PDPDYHTMVVGPTLNQCLVKYTRKKK

>4c0c-a1-m3-cA (length=446) [Search sequence]

Structure information

PDB ID	4c0c (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-fluorobenzamide.
Assembly ID	1
Resolution	2.04Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	80
Sequence identity between the two chains	1.0
PubMed citation	25101801

Chain information

	Chain 1	Chain 2
Model ID	2	3
Chain ID	A	A
UniProt accession	Q7Z1V1	Q7Z1V1
Species	5693 (Trypanosoma cruzi)	5693 (Trypanosoma cruzi)
Function annotation	BioLiP:4c0cA	BioLiP:4c0cA

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

4c0c-a1-m2-cA_4c0c-a1-m3-cA.pdb.gz

Full biological assembly

Download:

4c0c-assembly1.cif.gz

Similar dimers

Other dimers with similar sequences and structures	4c0c/1/1:A/2:A 4c0c/1/1:A/3:A 4uqh/1/1:A/2:A 4uqh/1/1:A/3:A 4uqh/1/2:A/3:A
Other dimers with similar sequences but different poses	4bmm/1/1:B/1:D 2wuz/1/1:A/1:B 4bmm/2/1:C/1:A