4d2w/2/1:C/1:B

Sequences
>4d2w-a2-m1-cC (length=313) [Search sequence]
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKSDLPRIKTEIEALKNL
RHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVH
SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKGALAYAAPELIQGKGSEADVWSMGILLY
VLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNH
PWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLL
LAKKARGKPVRLR
>4d2w-a2-m1-cB (length=323) [Search sequence]
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDCGALAYAAPELIQGGSEA
DVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKK
RISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQY
DHLTATYLLLLAKKARGKPVRLR
Structure information
PDB ID 4d2w (database links: RCSB PDB PDBe PDBj PDBsum)
Title Structure of MELK in complex with inhibitors
Assembly ID 2
Resolution 1.92Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 98
Sequence identity between the two chains 0.997
PubMed citation 25589925
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID C B
UniProt accession Q14680 Q14680
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:4d2wC BioLiP:4d2wB
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 4d2w-a2-m1-cC_4d2w-a2-m1-cB.pdb.gz
Full biological assembly
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Download: 4d2w-assembly2.cif.gz
Similar dimers
Other dimers with similar sequences and structures 4d2p/1/1:C/1:B 4d2v/1/1:C/1:B 4d2w/1/1:A/1:D 4ump/1/1:A/1:D 4ump/2/1:C/1:B 5twu/1/1:B/1:A

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