4e3c/3/1:D/1:E

Sequences

>4e3c-a3-m1-cD (length=624) [Search sequence]

EMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVA ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRY LHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLE QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKF SSSLPYPNNLNSVLAERLEKWLQLMLMWHPRTDPTYGPNGCFKALDDILNLKLVHILNMV TGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDDMDLV FLFDNSKISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRA AMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLA WREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSTLDDLEEQARELYRRLREKPRDQ RTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEK TVVRLQEKRQKELWNLLKIACSKV

>4e3c-a3-m1-cE (length=624) [Search sequence]

EMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVA ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRY LHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLE QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKF SSSLPYPNNLNSVLAERLEKWLQLMLMWHPRTDPTYGPNGCFKALDDILNLKLVHILNMV TGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDDMDLV FLFDNSKISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRA AMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLA WREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSTLDDLEEQARELYRRLREKPRDQ RTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEK TVVRLQEKRQKELWNLLKIACSKV

Structure information

PDB ID	4e3c (database links: RCSB PDB PDBe PDBj PDBsum)
Title	X-ray crystal structure of human IKK2 in an active conformation
Assembly ID	3
Resolution	3.98Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	79
Sequence identity between the two chains	1.0

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	D	E
UniProt accession	O14920	O14920
Species	9606 (Homo sapiens)	9606 (Homo sapiens)

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Download: 4e3c-a3-m1-cD_4e3c-a3-m1-cE.pdb.gz

Full biological assembly Download: 4e3c-assembly3.cif.gz

Similar dimers

Other dimers with similar sequences but different poses

4kik/1/1:A/1:B 4e3c/2/1:C/1:B