4fgt/1/1:D/2:A |
| >4fgt-a1-m1-cD (length=4) [Search sequence] |
| CQLY |
| >4fgt-a1-m2-cA (length=265) [Search sequence] |
GELQYLGQIQHILRCGVRADDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEEL
LWFIKGSTNAKELSSKGVKIWREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRV
IDTIKTNPDDRRIIMCAWNPRDLPLMALPPHALQFYVVNSELSCQLYQRSGDMGLGVPFN
IASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVE
KIDDFKAEDFQIEGYNPHPTIKMEM |
|
| PDB ID |
4fgt (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme. |
| Assembly ID |
1 |
| Resolution |
2Å |
| Method of structure determination |
X-RAY DIFFRACTION |
| Number of inter-chain contacts |
19 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
25427005 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
1 |
2 |
| Chain ID |
D |
A |
| UniProt accession |
|
P04818 |
| Species |
32630 (synthetic construct) |
9606 (Homo sapiens) |
| Function annotation |
BioLiP:4fgtA |
|
Switch viewer: [NGL] [JSmol]
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Dimer structure:
Chain 1 in red;
Chain 2 in blue.
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Full biological assembly
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