4gu6/1/1:B/1:A

Sequences
>4gu6-a1-m1-cB (length=258) [Search sequence]
YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT
MRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL
AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRLPIKWMAPESINFRRFTSASDVWMF
GVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPR
FTELKAQLSTILEEEKAQ
>4gu6-a1-m1-cA (length=271) [Search sequence]
DYEIQRERIELGRCIGEGQFGDVHQGIYMSNPALAVAIKTCKNCTSDSVREKFLQEALTM
RQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALA
YLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN
FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLM
TKCWAYDPSRRPRFTELKAQLSTILEEEKAQ
Structure information
PDB ID 4gu6 (database links: RCSB PDB PDBe PDBj PDBsum)
Title FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-{3-[(5-Cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}-N-methyl-methanesulfonamide
Assembly ID 1
Resolution 1.95Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 26
Sequence identity between the two chains 0.992
PubMed citation 23294348
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID B A
UniProt accession Q05397 Q05397
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:4gu6B BioLiP:4gu6A
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 4gu6-a1-m1-cB_4gu6-a1-m1-cA.pdb.gz
Full biological assembly
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Download: 4gu6-assembly1.cif.gz
Similar dimers
Other dimers with similar sequences but different poses
  • 4ny0/2/1:A/1:C 4ny0/1/1:B/1:D
  • 4d5k/1/1:A/1:B 6gcw/1/1:A/1:B
  • 6ty4/1/1:A/1:B 6ty3/1/1:A/1:B
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