4hz5/12/1:E/4:H

Sequences
>4hz5-a12-m1-cE (length=191) [Search sequence]
GLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNAVDEALSGYGNEINVTIQKDNSICVADSG
RGMPTGMHASGIPTVEVIFTVLHHGVGASVVNALSKWLEVHIVRDGVEYMERFEDGGKPV
GTLKKIGKTKKRNGTSVTFLPDDTIFSTTNFSYEILAERLRESAFLLKGVKITLTDERGE
EPKEEVFHYEE
>4hz5-a12-m4-cH (length=191) [Search sequence]
GLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNAVDEALSGYGNEINVTIQKDNSICVADSG
RGMPTGMHASGIPTVEVIFTVLHHGVGASVVNALSKWLEVHIVRDGVEYMERFEDGGKPV
GTLKKIGKTKKRNGTSVTFLPDDTIFSTTNFSYEILAERLRESAFLLKGVKITLTDERGE
EPKEEVFHYEE
Structure information
PDB ID 4hz5 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
Assembly ID 12
Resolution 2.7Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 43
Sequence identity between the two chains 1.0
PubMed citation 23352267
Chain information
Chain 1 Chain 2
Model ID 1 4
Chain ID E H
UniProt accession H7C794 H7C794
Species 226185 (Enterococcus faecalis V583) 226185 (Enterococcus faecalis V583)
Function annotation BioLiP:4hz5E
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 4hz5-a12-m1-cE_4hz5-a12-m4-cH.pdb.gz
Full biological assembly
Download: 4hz5-assembly12.cif.gz
Similar dimers
Other dimers with similar sequences and structures 4hz5/10/1:A/1:C 4hz5/10/1:D/1:A 4hz5/10/1:D/1:C 4hz5/11/1:G/2:B 4hz5/11/1:J/1:G 4hz5/11/1:J/2:B 4hz5/12/1:E/3:F 4hz5/12/3:F/4:H

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