4nka/1/1:A/1:B

Sequences

>4nka-a1-m1-cA (length=279) [Search sequence]

ELPEDPRWELPRDRLVLGKPLGEQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSD LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPEEQLSSKD LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGIDYYKKTTNGRLPVKW MAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

>4nka-a1-m1-cB (length=287) [Search sequence]

AGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKPNRVTKVAVKMLKSD ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFHHIDYYKKTT NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE

Structure information

PDB ID	4nka (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2
Assembly ID	1
Resolution	2.19Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	41
Sequence identity between the two chains	0.986
PubMed citation	24900792

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	A	B
UniProt accession	P11362	P11362
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:4nkaA	BioLiP:4nkaB

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black]   [White]   Download: 4nka-a1-m1-cA_4nka-a1-m1-cB.pdb.gz

Full biological assembly Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black quality]   [White quality]   Download: 4nka-assembly1.cif.gz

Similar dimers

Other dimers with similar sequences and structures	4nk9/1/1:A/1:B 5vnd/3/1:B/1:A
Other dimers with similar sequences but different poses	3c4f/3/1:A/2:A 3gql/4/1:B/1:A 3js2/2/1:B/1:A 3js2/1/1:B/1:A 3kxx/6/1:C/1:B 3kxx/5/1:D/1:A