4o0r/3/2:B/1:A

Sequences

>4o0r-a3-m2-cB (length=282) [Search sequence]

SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQKELI
INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRE
CLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGQSKRSEMVGTPYWMAPEVVTRKA
YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR
CLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK

>4o0r-a3-m1-cA (length=293) [Search sequence]

SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK
KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAA
VCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSEMVGTP
YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE
KLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT

Structure information

PDB ID	4o0r (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Assembly ID	3
Resolution	2.4Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	46
Sequence identity between the two chains	0.996
PubMed citation	24432870

Chain information

	Chain 1	Chain 2
Model ID	2	1
Chain ID	B	A
UniProt accession	Q13153	Q13153
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:4o0rA

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

4o0r-a3-m2-cB_4o0r-a3-m1-cA.pdb.gz

Full biological assembly

Download:

4o0r-assembly3.cif.gz